Explanipedia

Effect of direct oral anticoagulants in cirrhosis: an in vitro study Open

Cindy Pereira Portela, Debora Bertaggia Calderara, Elise Mdawar-Bailly, Alessandro Aliotta, Lucas Veuthey , et al. · 2025

The anticoagulant potency of DOAC differs according to the individual procoagulant potential. Highly procoagulant plasma from patients with cirrhosis is less sensitive to the anticoagulant action of apixaban, edoxaban, and rivaroxaban than…

Monitoring of hepatitis E virus infection and replication by functional tagging of the ORF2 protein Open

Maliki Ankavay, Nathalie Da Silva, Angela Pollán, Noémie Oechslin, Katja Dinkelborg , et al. · 2024

HEV ORF2 protein-antibody complex deposits are associated with glomerulonephritis in hepatitis E with reduced immune status Open

Anne‐Laure Leblond, Birgit Helmchen, Maliki Ankavay, Daniela Lenggenhager, Jasna Jetzer , et al. · 2024

Hepatitis E virus (HEV) infection, one of the most common forms of hepatitis worldwide, is often associated with extrahepatic, particularly renal, manifestations. However, the underlying mechanisms are incompletely understood. Here, we rep…

Trends in the burden of hospitalised patients with cirrhosis in Switzerland: a cross-sectional study of cirrhosis-related hospitalisations between 1998 and 2020 Open

Timothée Favre-Bulle, Darius Moradpour, Pedro Marques‐Vidal, Julien Vaucher · 2024

Objective Liver cirrhosis is an increasing cause of morbidity and mortality worldwide with a heavy load on healthcare systems. We analysed the trends in hospitalisations for cirrhosis in Switzerland. Design Cross-sectional study. Setting L…

High prevalence of short telomeres in idiopathic porto-sinusoidal vascular disorder Open

Alexander Coukos, Chiara Saglietti, Christine Sempoux, Monika Haubitz, Thomas Greuter , et al. · 2024

Background: Telomeres prevent damage to coding DNA as end-nucleotides are lost during mitosis. Mutations in telomere maintenance genes cause excessive telomere shortening, a condition known as short telomere syndrome (STS). One hepatic man…

Effect of Direct Acting Antiviral Drugs on the Occurrence and Recurrence of Intra- and Extra-Hepatic Malignancies in Patients with Chronic Hepatitis C Virus Infection Open

Pompilia Radu, Chiara Becchetti, Jonas Schropp, Patrick Schmid, Patrizia Künzler‐Heule , et al. · 2024

Introduction: The use of direct-acting antivirals (DAAs) has drastically changed the management of HCV-infected patients by achieving a 95–98% sustained virologic response (SVR) and reducing morbidity and mortality in this population. Howe…

Real-life experience of chronic hepatitis C treatment in Switzerland: a retrospective analysis Open

Eleni Moschouri, Gloria Salemme, Adriana Baserga, Andreas Cerny, Ansgar Deibel , et al. · 2024

BACKGROUND AND AIM: Direct-acting antivirals (DAAs) have revolutionised the management of chronic hepatitis C. We analysed the use of different generations of DAAs over time in Switzerland and investigated factors predictive of treatment f…

Joint host-pathogen genomic analysis identifies hepatitis B virus mutations associated with human NTCP and HLA class I variation Open

Zhi Ming Xu, Gnimah Eva Gnouamozi, Sina Rüeger, Patrick R. Shea, Marı́a Buti , et al. · 2024

Direct oral anticoagulants in cirrhosis: Rationale and current evidence Open

Cindy Pereira Portela, Lucas A. Gautier, Maxime G. Zermatten, Montserrat Fraga, Darius Moradpour , et al. · 2024

Rare HCV subtypes and retreatment outcomes in a cohort of European DAA-experienced patients Open

Julia Dietz, Christiana Graf, Christoph P. Berg, Kerstin Port, Katja Deterding , et al. · 2024

Data on the prevalence and characteristics of rare HCV genotypes (GT) in larger cohorts are still scarce. This study found low rates of rare HCV GTs among European HCV-infected patients. In direct-acting antiviral (DAA)-failure patients, r…

A genome-wide CRISPR/Cas9 screen identifies a role for Rab5A and early endosomes in hepatitis E virus replication Open

Noémie Oechslin, Nathalie Da Silva, Maliki Ankavay, Darius Moradpour, Jérôme Gouttenoire · 2023

Hepatitis E virus (HEV) is a major cause of acute hepatitis worldwide. As the other positive-strand RNA viruses, it is believed to replicate its genome in a membrane-associated replication complex. However, current understanding of the hos…

Inborn errors of type I interferon immunity in patients with symptomatic acute hepatitis E Open

Saadat Ali, Jérôme Gouttenoire, Paolo Ripellino, David Semela, Soraya Amar , et al. · 2023

Background and Aims: The clinical spectrum of human infection by HEV ranges from asymptomatic to severe acute hepatitis. Furthermore, HEV can cause diverse neurological manifestations, especially Parsonage-Turner syndrome. Here, we used a …

PB0548 Efficacy of Direct Oral Anticoagulants in Liver Cirrhosis: An in-vitro Study Open

C. Pereira Portela, Maxime G. Zermatten, Debora Bertaggia Calderara, Melissa Mariti Fraga, Alessandro Aliotta , et al. · 2023

Within-run precision and between-run imprecision of the ACTICHROME Heparin Anti-Xa™ assay.

PB1052 Evaluating the Individual Risk of Venous Thrombo-Embolism in Patients with Liver Cirrhosis: Usefulness of in vivo and ex vivo Thrombin Generation Parameters Open

Cindy Pereira Portela, Montserrat Fraga, Maxime G. Zermatten, Debora Bertaggia Calderara, Alessandro Aliotta , et al. · 2023

use in subjects.

A HEV ORF2 protein-mediated mechanism of hepatitis E-associated kidney disease Open

Birgit Helmchen, Anne‐Laure Leblond, Daniela Lenggenhager, Jasna Jetzer, Maliki Ankavay , et al. · 2023

Hepatitis E virus (HEV) infection, one of the most common forms of hepatitis worldwide, is often associated with extrahepatic, particularly renal, manifestations. However, the underlying mechanisms are incompletely understood. Here, we rep…

Elevated liver function tests in a patient with breast cancer Open

Cyril Neftel, Khalil Zaman, Haïthem Chtioui, Darius Moradpour, Christine Sempoux , et al. · 2023

A 49-year-old female was diagnosed with invasive lobular breast carcinoma, grade 3, cT2 cN0 cM0, endocrine resistant and positive for human epidermal growth factor receptor 2 (HER2), in February 2022. She underwent neoadjuvant chemotherapy…

Body composition and short-term mortality in patients critically ill with acute-on-chronic liver failure Open

Thomas Mangana del Rio, Sophie‐Caroline Sacleux, Julien Vionnet, Philippe Ichaı̈, Alban Denys , et al. · 2023

Expanding the Hepatitis E Virus Toolbox: Selectable Replicons and Recombinant Reporter Genomes Open

Noémie Oechslin, Maliki Ankavay, Darius Moradpour, Jérôme Gouttenoire · 2023

Hepatitis E virus (HEV) has received relatively little attention for decades although it is now considered as one of the most frequent causes of acute hepatitis worldwide. Our knowledge of this enterically-transmitted, positive-strand RNA …

Systematic comparison with autoimmune liver disease identifies specific histological features of immune checkpoint inhibitor-related adverse events Open

Alexander Coukos, Julien Vionnet, Michel Obéid, Hasna Bouchaab, Solange Peters , et al. · 2022

Background Immune checkpoint inhibitors (ICIs) have become a mainstay of cancer treatment. Their immune-boosting quality has one major drawback, their proclivity to induce a broad array of immune-related adverse events (irAEs) affecting, a…

Portal vein recanalisation alone to treat severe portal hypertension in non-cirrhotic patients with chronic extrahepatic portal vein obstruction Open

Florent Artru, Naïk Vietti Violi, Christine Sempoux, Joana Vieira Barbosa, Fabio Becce , et al. · 2022

Increasing prevalence of obesity and diabetes among patients evaluated for liver transplantation in a Swiss tertiary referral center: a 10-year retrospective analysis Open

Sophie Kasmi, Florent Artru, Joana Vieira Barbosa, Ansgar Deibel, Lucie Favre , et al. · 2022

BACKGROUND AND AIMS: Non-alcoholic fatty liver disease (NAFLD) is now the first cause of chronic liver disease in developed countries. We aimed to assess trends in the prevalence of obesity, type 2 diabetes mellitus (T2DM) and NAFLD in pat…

High-dimensional immune phenotyping of blood cells by mass cytometry in patients infected with hepatitis C virus Open

Jacobus Herderschee, Tytti Heinonen, Craig Fenwick, Irene T. Schrijver, Khalid Ohmiti , et al. · 2021

Hepatitis E virus RNA‐dependent RNA polymerase is involved in RNA replication and infectious particle production Open

Noémie Oechslin, Nathalie Da Silva, Dagmara Szkolnicka, François‐Xavier Cantrelle, Xavier Hanoulle , et al. · 2021

Background and Aims Hepatitis E virus (HEV) is one of the most common causes of acute hepatitis worldwide. Its positive‐strand RNA genome encodes three open reading frames (ORF). ORF1 is translated into a large protein composed of multiple…

Case Report: SARS-CoV-2 as an unexpected causal agent of predominant febrile hepatitis Open

Paraskevas Filippidis, Francois van Ouwenaller, Alberto Cerutti, Anaïs Geiger-Jacquod, Christine Sempoux , et al. · 2021

Background: Respiratory symptoms and pneumonia are the predominant features of Coronavirus disease 2019 (COVID-19) due to emerging SARS-CoV-2 virus, but extrapulmonary manifestations are also observed. For instance, some degree of liver in…

Case Report: SARS-CoV-2 as an unexpected causal agent of isolated febrile hepatitis Open

Paraskevas Filippidis, Francois van Ouwenaller, Alberto Cerutti, Anaïs Geiger-Jacquod, Christine Sempoux , et al. · 2021

Background: Respiratory symptoms and pneumonia are the predominant features of Coronavirus disease 2019 (COVID-19) due to emerging SARS-CoV-2 virus, but extrapulmonary manifestations are also observed. For instance, some degree of liver in…

Autochthonous hepatitis E as a cause of acute-on-chronic liver failure and death: histopathology can be misleading but transaminases may provide a clue Open

Joana Vieira Barbosa, Beat Müllhaupt, Felix Brunner, Magdalena Filipowicz Sinnreich, David Semela , et al. · 2021

BACKGROUND AND AIM Acute decompensation and death have been observed in patients with acute hepatitis E virus (HEV) infection and preexisting liver cirrhosis. However, the clinical, laboratory and histological features need to be fully cha…

Demographics and outcomes of hepatitis B and D: A 10-year retrospective analysis in a Swiss tertiary referral center Open

Joana Vieira Barbosa, Roland Sahli, Vincent Aubert, Aziz Chaouch, Darius Moradpour , et al. · 2021

Background Hepatitis B virus (HBV) is a major global health challenge with approximately 250–350 million chronically infected individuals. An improved understanding of the demographic features and outcomes of chronic HBV infection and hepa…

Empfehlungen für die Nachsorge von Patientinnen/Patienten mit ausgeheilter Hepatitis C Open

Carina Bobzin, Christophe Bsiger, Philip Bruggmann, Andreas Cerny, Montserrat Fraga Christinet , et al. · 2021

Diese Empfehlungen wurden in Zusammenarbeit verschiedener Fachgesellschaften und Patientenorganisationen erarbeitet und dienen dazu, ein Nachsorgeprogramm fur erfolgreich behandelte Patientinnen und Patienten zu etablieren.

Recommandations pour le suivi des patients atteints d’hépatite C guérie Open

Carina Bobzin, Christophe Bsiger, Philip Bruggmann, Andreas Cerny, Montserrat Fraga Christinet , et al. · 2021

Ces recommandations ont ete elaborees par diverses societes professionnelles et organisations de patients pour assurer un programme de suivi pour les patients traites avec succes.

86th annual congress of the Swiss Society of Pathology Open

Rainer Grobholz, Gieri Cathomas, Runtian Miao, Rob Toth, Anant Madabhushi , et al. · 2020

Darius Moradpour YOU? Author Swipe