Dariusz Lebensztejn
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Serum cytokine inflammatory profile in children with ulcerative colitis during 6-month follow-up Open
The involvement of inflammation in the development of ulcerative colitis (UC) is significant. Therefore, the purpose of our study was to evaluate the serum levels of selected cytokines, chemokines and growth factors in children at the time…
Case Report: Autoimmune polyglandular syndrome type 4 involving diabetes mellitus type 1, autoimmune hepatitis, immune thrombocytopenia, and celiac disease Open
Autoimmune polyglandular syndromes refer to a group of disorders characterized by dysfunction in two or more endocrine glands, often accompanied by autoimmune involvement in non-endocrine tissues. A 6-year-old girl was admitted due to susp…
Early and simple laboratory markers of poor outcome in children with IBD. Open
Introduction Personalized medicine in inflammatory bowel disease (IBD) aims to achieve maximum effectiveness through rapid induction and maintenance of remission. To achieve this goal, reliable predictors of disease course are needed. The …
Dysphagia Among Children—A Single-Center Experience Open
Background/Objectives: In recent years, there has been an increase in the prevalence of eosinophilic esophagitis (EoE), in which dysphagia is one of the main symptoms. To date, there are few data on the prevalence of EoE in pediatric patie…
Apoptosis markers in children with metabolic-associated fatty liver disease: a preliminary study Open
Our results suggest that the mechanism of apoptosis may play an important role in the development of MAFLD in children. There is a need for further studies in children to determine whether the M30 concentration may be an indicator of MAFLD…
Irisin as a marker of hepatic steatosis in children with metabolic dysfunction–associated steatotic liver disease Open
Aim The purpose of this study was to evaluate irisin, myonectin and high‐sensitivity interleukin‐6 (hs IL‐6) levels in obese children and adolescents and to determine the association of these parameters with metabolic dysfunction–associate…
Evaluation of microbiome composition combined with serum untargeted metabolomic profiling in newly diagnosed children with inflammatory bowel disease Open
Introduction The relationship between the intestinal microbiota, metabolites and inflammatory bowel disease (IBD) development is still being sought. We aimed to assess whether the gut microbiome and serum metabolic profile are consistent w…
Biochemical and Anthropometric Indices of Insulin Resistance in Obese and Overweight Children with Metabolic Dysfunction-Associated Fatty Liver Disease Open
BACKGROUND The prevalence of metabolic (dysfunction)-associated fatty liver disease (MAFLD) increases together with the epidemic of childhood obesity. An important mechanism in the phenomenon appears to be insulin resistance (IR), the asse…
Uric acid as a potential marker of cardiometabolic risk in children and adolescents with metabolic dysfunction associated steatotic liver disease Open
Our results suggest that UA may be a potential additional and readily available marker of metabolic dysfunction in children with MASLD. Further studies on a larger group of patients are needed to confirm this association.
Serum dihomo-g-linolenic acid concentrationas a potential novel noninvasive biomarkerfor liver steatosis detection in children Open
Serum DGLA levels may be considered as a potential novel non-invasive biomarker for liver steatosis detection in children. The differences in the serum concentrations of DGLA, LA and AA between the groups and correlations found between the…
“Real food” enteral formulas in everyday clinical practice Open
Enteral nutrition is a component of therapy for children whose ability to take in food by the natural route is impaired but whose gastrointestinal tract capacity still allows for nutrient digestion and absorption. According to guidelines, …
Medical Misinformation in Polish on the World Wide Web During the COVID-19 Pandemic Period: Infodemiology Study Open
Background Although researchers extensively study the rapid generation and spread of misinformation about the novel coronavirus during the pandemic, numerous other health-related topics are contaminating the internet with misinformation th…
Clinical Presentation and Co-Detection of Respiratory Pathogens in Children Under 5 Years with Non-COVID-19 Bacterial and Viral Respiratory Tract Infections: A Prospective Study in Białystok, Poland (2021-2022) Open
BACKGROUND Respiratory tract infections (RTIs) in children often involve a complex interplay between viruses and bacteria. This study aimed to evaluate clinical presentation in children under 5 years old diagnosed with non-COVID-19 bacteri…
Antibiotic-Resistant Strains of Helicobacter pylori in 50 Antibiotic Treatment-Naive Children in Northeast Poland Diagnosed by Gastric or Duodenal Biopsy Between February 2019 and May 2022 Open
BACKGROUND In recent years, an increasing prevalence of Helicobacter pylori resistance to antibiotics has been observed. The aim of this study was to assess antibiotic resistance of Helicobacter pylori in previously untreated children from…
Escherichia albertii as a Potential Enteropathogen in the Light of Epidemiological and Genomic Studies Open
Escherichia albertii is a new enteropathogen of humans and animals. The aim of the study was to assess the prevalence and pathogenicity of E. albertii strains isolated in northeastern Poland using epidemiological and genomic studies. In 20…
Pancreatic Involvement in the Course of Inflammatory Bowel Disease in Children—A Multi-Center Study Open
The coexistence of inflammatory bowel disease (IBD) with pancreatic pathology is rare in children. A retrospective analysis of data from 1538 children diagnosed with IBD in 2014–2021 was conducted to determine the frequency and causes of p…
Unraveling the Interplay between Nonalcoholic Fatty Liver Disease and Polycystic Ovary Syndrome in Adolescents: Pathogenesis, Prevalence, and Management Strategies Open
BACKGROUND With the expanding understanding of conditions contributing to heightened cardiovascular risk, emerging pathologies like nonalcoholic fatty liver disease (NAFLD) and polycystic ovary syndrome (PCOS) are being recognized as hepat…
Medical Misinformation in Polish on the World Wide Web During the COVID-19 Pandemic Period: Infodemiology Study (Preprint) Open
BACKGROUND Although researchers extensively study the rapid generation and spread of misinformation about the novel coronavirus during the pandemic, numerous other health-related topics are contaminating the internet with misinformation th…
View article: Thrombospondin-2 as a potential noninvasive biomarker of hepatocyte injury but not liver fibrosis in children with MAFLD: A preliminary study
Thrombospondin-2 as a potential noninvasive biomarker of hepatocyte injury but not liver fibrosis in children with MAFLD: A preliminary study Open
TSP2 may be a potential biomarker of hepatocyte injury in pediatric patients with MAFLD. None of the examined biomarkers were found to be effective non-invasive markers of liver fibrosis in children.
Guidelines for the diagnosis and management of histamine intolerance Open
AMA Buczyłko K, Bartnicka A, Kruszewski J, et al. Guidelines for the diagnosis and management of histamine intolerance. Alergologia Polska - Polish Journal of Allergology. 2023;10(3):141-151. doi:10.5114/pja.2023.131553. APA Buczyłko, K., …
The Etiology of Cholelithiasis in Children and Adolescents—A Literature Review Open
The incidence of gallstone disease has increased in recent years. The pathogenesis of cholelithiasis is not fully understood. The occurrence of the disease is influenced by both genetic and environmental factors. This article reviews the l…
Analysis of Sphingolipids in Pediatric Patients with Cholelithiasis—A Preliminary Study Open
(1) Background: Disturbances in the sphingolipid profile are observed in many diseases. There are currently no data available on the evaluation of sphingolipids and ceramides in cholelithiasis in children. The aim of this study was to eval…
Autoimmune sclerosing cholangitis might be triggered by SARS-CoV-2 infection in a child – a case report Open
The spectrum of liver involvement during coronavirus disease 2019 (COVID-19) is broad and mainly includes elevated liver enzymes and cholestasis. Severe acute respiratory syndrome corona- virus-2 (SARS-CoV-2) infection most often leads to …
Increase in Serum MMP-9 and TIMP-1 Concentrations during Alcohol Intoxication in Adolescents—A Preliminary Study Open
Background: Alcohol consumption by adolescents is responsible for a number of adverse health and social outcomes. Despite the well-established effect of alcohol use on the development of alcoholic liver disease, the relationship between th…
Are Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 Useful as Markers in Diagnostic Management of Children with Newly Diagnosed Ulcerative Colitis? Open
Matrix Metaloproteinase-9 (MMP-9) and Tissue Inhibitor of Metaloproteinase-1 (TIMP-1), enzymes involved in tissue remodelling, have been previously reported to be overexpressed in the colonic mucosa of patients with Ulcerative colitis (UC)…
Chemerin as Potential Biomarker in Pediatric Diseases: A PRISMA-Compliant Study Open
Adipose tissue is the main source of adipokines and therefore serves not only as a storage organ, but also has an endocrine effect. Chemerin, produced mainly in adipocytes and liver, is a natural ligand for chemokine-like receptor 1 (CMKLR…
Common variant p.<span>D</span>19<span>H</span> of the hepatobiliary sterol transporter <span><i>ABCG8</i></span> increases the risk of gallstones in children Open
Introduction Gallstones are increasingly common in children. Genetic analyses of adult cohorts demonstrated that the sterol transporter ABCG8 p.D19H and Gilbert UGT1A1*28 variants enhance the odds of developing gallstones. The genetic back…