Darlene Dixon
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View article: A Review of the Most Frequent Compounds, Metals, and Compound and Metal Mixtures Found at U.S. Superfund Sites and Their Carcinogenic Potential
A Review of the Most Frequent Compounds, Metals, and Compound and Metal Mixtures Found at U.S. Superfund Sites and Their Carcinogenic Potential Open
The United States Environmental Protection Agency's (U.S. EPA) National Priorities List (NPL) is a list of sites in the U.S. and its territories of national priority that are sources of known hazardous contaminants, pollutants, or substanc…
View article: Editorial: Environmental impacts on women’s health disparities and reproductive health: advancing environmental health equity in clinical and public health practice
Editorial: Environmental impacts on women’s health disparities and reproductive health: advancing environmental health equity in clinical and public health practice Open
View article: Systematic evidence maps of psychosocial stressors, environmental exposures, and cardiovascular diseases to inform health disparities research and action
Systematic evidence maps of psychosocial stressors, environmental exposures, and cardiovascular diseases to inform health disparities research and action Open
View article: Induction of fibrosis following exposure to bisphenol A and its analogues in 3D human uterine leiomyoma cultures
Induction of fibrosis following exposure to bisphenol A and its analogues in 3D human uterine leiomyoma cultures Open
Bisphenol A (BPA) and its analogues (BPAF, BPS) are ubiquitous environmental contaminants used as plastic additives in various daily life products, with many concerns on their role as environmental estrogens. Uterine leiomyomas (fibroids) …
View article: Tobacco Smoke Condensate Induces Morphologic Changes in Human Papillomavirus-Positive Cervical Epithelial Cells Consistent with Epithelial to Mesenchymal Transition (EMT) with Activation of Receptor Tyrosine Kinases and Regulation of TGFB
Tobacco Smoke Condensate Induces Morphologic Changes in Human Papillomavirus-Positive Cervical Epithelial Cells Consistent with Epithelial to Mesenchymal Transition (EMT) with Activation of Receptor Tyrosine Kinases and Regulation of TGFB Open
High-risk human papillomavirus (HR-HPV; HPV-16) and cigarette smoking are associated with cervical cancer (CC); however, the underlying mechanism(s) remain unclear. Additionally, the carcinogenic components of tobacco have been found in th…
View article: Racism as a public health issue in environmental health disparities and environmental justice: working toward solutions
Racism as a public health issue in environmental health disparities and environmental justice: working toward solutions Open
View article: Broadening the Environmental Lens to Include Social and Structural Determinants of Women’s Health Disparities
Broadening the Environmental Lens to Include Social and Structural Determinants of Women’s Health Disparities Open
The challenges related to women's health equity, as identified by workshop attendees, included developing research approaches to better capture the social and structural environment in both human and animal studies, integrating environment…
View article: Supplementary Notes from Classification of Proliferative Pulmonary Lesions of the Mouse
Supplementary Notes from Classification of Proliferative Pulmonary Lesions of the Mouse Open
Supplementary Notes from Classification of Proliferative Pulmonary Lesions of the Mouse
View article: Supplementary Notes from Classification of Proliferative Pulmonary Lesions of the Mouse
Supplementary Notes from Classification of Proliferative Pulmonary Lesions of the Mouse Open
Supplementary Notes from Classification of Proliferative Pulmonary Lesions of the Mouse
View article: Data from Classification of Proliferative Pulmonary Lesions of the Mouse
Data from Classification of Proliferative Pulmonary Lesions of the Mouse Open
Rapid advances in generating new mouse genetic models for lung neoplasia provide a continuous challenge for pathologists and investigators. Frequently, phenotypes of new models either have no precedents or are arbitrarily attributed accord…
View article: Data from Classification of Proliferative Pulmonary Lesions of the Mouse
Data from Classification of Proliferative Pulmonary Lesions of the Mouse Open
Rapid advances in generating new mouse genetic models for lung neoplasia provide a continuous challenge for pathologists and investigators. Frequently, phenotypes of new models either have no precedents or are arbitrarily attributed accord…
View article: Chronic PFOA exposure in vitro causes acquisition of multiple tumor cell characteristics in rat liver cells
Chronic PFOA exposure in vitro causes acquisition of multiple tumor cell characteristics in rat liver cells Open
View article: Arsenic and diabetes mellitus: a putative role for the immune system
Arsenic and diabetes mellitus: a putative role for the immune system Open
Diabetes mellitus (DM) is an enormous public health issue worldwide. Recent data suggest that chronic arsenic exposure is linked to the risk of developing type 1 and type 2 DM, albeit the underlying mechanisms are unclear. This review disc…
View article: Engineering Human Cerebral Organoids to Explore Mechanisms of Arsenic-Induced Developmental Neurotoxicity
Engineering Human Cerebral Organoids to Explore Mechanisms of Arsenic-Induced Developmental Neurotoxicity Open
View article: Scoping report and interactive evidence map on studies of environmental exposures, psychosocial stressors, and cardiovascular diseases in disproportionally impacted communities
Scoping report and interactive evidence map on studies of environmental exposures, psychosocial stressors, and cardiovascular diseases in disproportionally impacted communities Open
Background and Aim Worldwide, cardiovascular disease (CVD) is the leading cause of death, with two-thirds of CVD- related deaths occurring in low- and middle-income countries. In addition to socioeconomic status (SES), CVD rates vary by ra…
View article: Prolonged Cadmium Exposure Alters Migration Dynamics and Increases Heterogeneity of Human Uterine Fibroid Cells—Insights from Time Lapse Analysis
Prolonged Cadmium Exposure Alters Migration Dynamics and Increases Heterogeneity of Human Uterine Fibroid Cells—Insights from Time Lapse Analysis Open
Cadmium (Cd) is one of the most prevalent environmental heavy metal contaminants and is considered an endocrine disruptor and carcinogen. In women with uterine fibroids, there is a correlation between blood Cd levels and fibroid tumor size…
View article: Short‐term tetrabromobisphenol A exposure promotes fibrosis of human uterine fibroid cells in a 3D culture system through TGF‐beta signaling
Short‐term tetrabromobisphenol A exposure promotes fibrosis of human uterine fibroid cells in a 3D culture system through TGF‐beta signaling Open
Tetrabromobisphenol A (TBBPA), a derivative of BPA, is a ubiquitous environmental contaminant with weak estrogenic properties. In women, uterine fibroids are highly prevalent estrogen‐responsive tumors often with excessive accumulation of …
View article: Genistein: Dual Role in Women’s Health
Genistein: Dual Role in Women’s Health Open
Advanced research in recent years has revealed the important role of nutrients in the protection of women’s health and in the prevention of women’s diseases. Genistein is a phytoestrogen that belongs to a class of compounds known as isofla…
View article: Prolonged cadmium exposure alters benign uterine fibroid cell behavior, extracellular matrix components, and TGFB signaling
Prolonged cadmium exposure alters benign uterine fibroid cell behavior, extracellular matrix components, and TGFB signaling Open
The heavy metal Cadmium (Cd), a widespread environmental contaminant, poses serious hazards to human health and is considered a metallohormone and carcinogen. In women with uterine fibroids, there is a significant association between blood…
View article: “Metalloestrogenic” effects of cadmium downstream of G protein-coupled estrogen receptor and mitogen-activated protein kinase pathways in human uterine fibroid cells
“Metalloestrogenic” effects of cadmium downstream of G protein-coupled estrogen receptor and mitogen-activated protein kinase pathways in human uterine fibroid cells Open
Cadmium (Cd) is a toxic metal reported to act as an estrogen “mimic” in the rat uterus and in vitro. We have reported that Cd stimulates proliferation of estrogen-responsive human uterine leiomyoma (ht-UtLM; fibroid) cells through nongenom…
View article: Differential receptor tyrosine kinase phosphorylation in the uterus of rats following developmental exposure to tetrabromobisphenol A
Differential receptor tyrosine kinase phosphorylation in the uterus of rats following developmental exposure to tetrabromobisphenol A Open
Tetrabromobisphenol A (TBBPA) is a brominated flame retardant that induces endometrial adenocarcinoma and other uterine tumors in Wistar Han rats; however, early molecular events or biomarkers of TBBPA exposure remain unknown. We investiga…
View article: Environmental Factors Involved in Maternal Morbidity and Mortality
Environmental Factors Involved in Maternal Morbidity and Mortality Open
Nongenetic, environmental factors contribute to maternal morbidity and mortality through chemical exposures via air, water, soil, food, and consumer products. Pregnancy represents a particularly sensitive window of susceptibility during wh…
View article: Histopathologic changes in the uterus, cervix and vagina of immature CD-1 mice exposed to low doses of perfluorooctanoic acid (PFOA) in a uterotrophic assay
Histopathologic changes in the uterus, cervix and vagina of immature CD-1 mice exposed to low doses of perfluorooctanoic acid (PFOA) in a uterotrophic assay Open
The estrogenic and antiestrogenic potential of perfluorooctanoic acid (PFOA) was assessed using an immature mouse uterotrophic assay and by histologic evaluation of the uterus, cervix and vagina following treatment. Female offspring of CD-…
View article: Summary of the proceedings of the Basic Science of Uterine Fibroids meeting: new developments (February 28, 2020)
Summary of the proceedings of the Basic Science of Uterine Fibroids meeting: new developments (February 28, 2020) Open
View article: Modulatory Role for Retinoid-related Orphan Receptor α in Allergen-induced Lung Inflammation
Modulatory Role for Retinoid-related Orphan Receptor α in Allergen-induced Lung Inflammation Open
Rationale: Nuclear receptors play a critical role in the regulation of inflammation, thus representing attractive targets for the treatment of asthma.
View article: Characterization of primary mouse hepatocyte spheroids as a model system to support investigations of drug-induced liver injury
Characterization of primary mouse hepatocyte spheroids as a model system to support investigations of drug-induced liver injury Open
View article: Evaluation of Cystic Endometrial Hyperplasia and the Normal Estrous Cycle in Longitudinal Sections of Uterus from Female Harlan Sprague-Dawley Rats
Evaluation of Cystic Endometrial Hyperplasia and the Normal Estrous Cycle in Longitudinal Sections of Uterus from Female Harlan Sprague-Dawley Rats Open
The National Toxicology Program (NTP) has recently introduced the practice of examining longitudinal histological sections of the female rodent uterus to improve the identification of non-neoplastic lesions, preneoplastic lesions, and uter…
View article: Endocrine Disruption and Reproductive Pathology
Endocrine Disruption and Reproductive Pathology Open
During the past 20 years, investigations involving endocrine active substances (EAS) and reproductive toxicity have dominated the landscape of ecotoxicological research. This has occurred in concert with heightened awareness in the scienti…
View article: Epigenetic Enzymes, Age, and Ancestry Regulate the Efficiency of Human iPSC Reprogramming
Epigenetic Enzymes, Age, and Ancestry Regulate the Efficiency of Human iPSC Reprogramming Open
Epigenetic enzymes regulate higher-order chromatin architecture and cell-type specific gene expression. The ATPase BRG1 and the SWI/SNF chromatin remodeling complex are epigenetic enzymes that regulate chromatin accessibility during steady…
View article: Preparation of Three-dimensional (3-D) Human Liver (HepaRG) Cultures for Histochemical and Immunohistochemical Staining and Light Microscopic Evaluation
Preparation of Three-dimensional (3-D) Human Liver (HepaRG) Cultures for Histochemical and Immunohistochemical Staining and Light Microscopic Evaluation Open
The use of three-dimensional (3-D) in vitro culture systems (spheroids, organoids) in biomolecular and drug discovery research has become increasingly popular. The popularity is due, in part, to a diminished reliance on animal bioassays an…