Explanipedia

Non-obese genetic type 2 diabetes causes brain and behavioral hallmarks of chronic stress Open

Marina Romaní‐Pérez, Mathilde S. Henry, C. Pajot, Danielle Bailbé, Julie Brossaud , et al. · 2025

The comorbidity of obesity, type 2 diabetes (T2D), and psychiatric disorders— particularly anxiety and depression—is well documented. However, it remains unclear whether T2D, independently of obesity, contributes to the development of emot…

Role of early life adversities in inflammation-related neuropsychiatric comorbidity in obesity Open

Juliette Montet, Sandra Dexpert, Muriel Darnaudéry, Cédric Beau, Damien Forestier , et al. · 2025

Early movement restriction impairs the development of sensorimotor integration, motor skills and memory in rats: Towards a preclinical model of developmental coordination disorder? Open

Hanane Khalki, Diego Cabral Lacerda, Corane Karoutchi, Maxime Delcour, Orlane Dupuis , et al. · 2024

Children with neurodevelopmental disorders, such as developmental coordination disorder (DCD), exhibit gross to fine sensorimotor impairments, reduced physical activity and interactions with the environment and people. This disorder co‐exi…

Strain-specific changes in nucleus accumbens transcriptome and motivation for palatable food reward in mice exposed to maternal separation Open

Simon Benoît, Mathilde S. Henry, Sara Fneich, Alexia Mathou, Lin Xia , et al. · 2023

Introduction In humans, adversity in childhood exerts enduring effects on brain and increases the vulnerability to psychiatric diseases. It also leads to a higher risk of eating disorders and obesity. Maternal separation (MS) in mice has b…

Strain-specific changes in nucleus accumbens transcriptome and motivation for food reward in mice exposed to maternal separation Open

Mathilde S. Henry, Sara Fneich, Alexia Mathou, Lin Xia, Aline Foury , et al. · 2023

Adversity in childhood exerts enduring effects on brain and increases the vulnerability to psychiatric diseases. It also leads to a higher risk for eating disorders and obesity. We hypothesised that neonatal stress in mice affects motivati…

Stressing Glucose: At the Crossroads of Early Life Adversity, HPA Axis Reactivity and Carbohydrate Metabolism Open

Snehaa V. Seal, Myriam P. Merz, Sara B. Fernandes, Sophie B. Mériaux, Pauline Guébels , et al. · 2022

External stressors strongly increase cardiovascular activity and induce metabolic changes that ensure the availability of glucose and oxygen as part of a co-ordinated stress response. Exposure to stress during early life appears to have an…

A Holistic View of the Goto-Kakizaki Rat Immune System: Decreased Circulating Immune Markers in Non- Obese Type 2 Diabetes Open

Snehaa V. Seal, Mathilde Henry, C. Pajot, Cyrielle Holuka, Danielle Bailbé , et al. · 2022

Type-2 diabetes is a complex disorder that is now considered to have an immune component, with functional impairments in many immune cell types. Type-2 diabetes is often accompanied by comorbid obesity, which is associated with low grade i…

A new experimental design to study inflammation-related versus non-inflammation-related depression in mice Open

Pierre Cardinal, Camille Monchaux de Oliveira, Julie Sauvant, Aline Foury, Muriel Darnaudéry , et al. · 2021

Background Major depressive disorder (MDD) represents a major public health concern, particularly due to its steadily rising prevalence and the poor responsiveness to standard antidepressants notably in patients afflicted with chronic infl…

Depression and therapeutic resistance: complementary models to study inflammatory versus non-inflammatory depression in mice Open

Nathalie Castanon, Camille Monchaux de Oliveira, Pierre Cardinal, Julie Sauvant, Alexandra Lavielle , et al. · 2021

Depression represents a major public health concern. Its prevalence is continuously rising, notably in patients exposed to chronic stress or suffering from medical conditions associated with low-grade chronic inflammation, such as obesity.…

Targeted Intestinal Tight Junction Hyperpermeability Alters the Microbiome, Behavior, and Visceromotor Responses Open

Orsolya Inczefi, Valérie Bacquie, Maı̈wenn Olier, Marion Rincel, B. Ringot-Destrez , et al. · 2020

The prebiotic lactulose does not affect olfactory neurogenesis in a sheep model of early life stress Open

Roberta Vitiello, Maryse Meurisse, Frédéric Lévy, Céline Parias, Scott Love , et al. · 2019

The prebiotic lactulose does not affect olfactory neurogenesis in a sheep model of early life stress. FENS regional meeting

Maternal separation in rodents: a journey from gut to brain and nutritional perspectives Open

Marion Rincel, Muriel Darnaudéry · 2019

The developmental period constitutes a critical window of sensitivity to stress. Indeed, early-life adversity increases the risk to develop psychiatric diseases, but also gastrointestinal disorders such as the irritable bowel syndrome at a…

Multi-hit early life adversity affects gut microbiota, brain and behavior in a sex-dependent manner Open

Marion Rincel, P. Aubert, J. Chevalier, P.‐A. Grohard, Lilian Basso , et al. · 2019

Prenatal retinoic acid exposure reveals candidate genes for craniofacial disorders Open

Marie Berenguer, Muriel Darnaudéry, Stéphane Claverol, Marc Bonneu, Didier Lacombe , et al. · 2018

Unlimited sucrose consumption during adolescence generates a depressive-like phenotype in adulthood Open

Aliou B. Gueye, Leandro F. Vendruscolo, Camila de Ávila, Catherine Le Moine, Muriel Darnaudéry , et al. · 2018

Les dérégulations de transcriptome et du méthylome hépatique associées au stress nutritionnel et psychosocial maternel sont amplifiées par un régime post-sevrage hypergras chez la souris Open

Sara Fneich, Lin Xia, Claudine Junien, Marlène Dufresne, Jérôme Torrisani , et al. · 2018

National audience

Oral Presentations: Dietary interventions including probiotics, prebiotics and synbiotics Open

Marion Rincel, Lin Xia, Camille Monchaux de Oliveira, Julie Thomas, Valérie Alquier‐Bacquie , et al. · 2017

à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

Maternal high-fat diet prevents developmental programming by early-life stress Open

Marion Rincel, Amandine Lépinay, Pierre-Jérôme Delage, J Fioramonti, Vassilia Théodorou , et al. · 2016

The early life nutritional environment and early life stress as potential pathways towards the metabolic syndrome in mid-life? A lifecourse analysis using the 1958 British Birth cohort Open

Cyrille Delpierre, Romain Fantin, Cristina Barboza‐Solís, Benoît Lepage, Muriel Darnaudéry , et al. · 2016

Les adversités durant l’enfance et la charge allostatique à l’âge adulte : résultats de la cohorte de naissances britannique de 1958 Open

Cristina Barboza‐Solís, Michelle Kelly‐Irving, Romain Fantin, Muriel Darnaudéry, Jérôme Torrisani , et al. · 2016

Origins of heath inequalities: the case for Allostatic Load Open

Cyrille Delpierre, Cristina Barboza‐Solís, Jérôme Torrisani, Muriel Darnaudéry, Mel Bartley , et al. · 2016

n an opening paper Cyrille Delpierre, Cristina Barbosa-Solis, Jerome Torrisani, Muriel Darnaudery, Melanie Bartley, David Blane and Michelle Kelly-Irving explore the concept of Allostatic Load as a way of examining health inequalities. The…

Environnement précoce et vulnérabilité neuropsychiatrique Open

Marion Rincel, Amandine Lépinay, Anne Gabory, Vassilia Théodorou, Muriel Koehl , et al. · 2016

The human newborn is highly dependent on parental care for its survival but also for the healthy development of its brain. A large body of literature demonstrates the impact of early life adversity, even during the prenatal period, on the …

Juvenile Obesity Enhances Emotional Memory and Amygdala Plasticity through Glucocorticoids Open

Chloé Boitard, Mouna Maroun, Frédéric Tantot, Amandine Cavaroc, Julie Sauvant , et al. · 2015

In addition to metabolic and cardiovascular disorders, obesity is associated with adverse cognitive and emotional outcomes. Its growing prevalence during adolescence is particularly alarming since recent evidence indicates that obesity can…

Adverse childhood experiences and physiological wear-and-tear in midlife: Findings from the 1958 British birth cohort Open

Cristina Barboza‐Solís, Michelle Kelly‐Irving, Romain Fantin, Muriel Darnaudéry, Jérôme Torrisani , et al. · 2015

Significance The role of early life experiences on health is of major concern to research. Recent studies have shown that chronic stress may “get under the skin” to alter human developmental processes and impact later health. Our findings …

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