Darrell Andrews
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View article: Extracellular vesicles derived from induced pluripotent stem cells mediate anti- inflammatory effects in primary human macrophages
Extracellular vesicles derived from induced pluripotent stem cells mediate anti- inflammatory effects in primary human macrophages Open
Extracellular vesicles derived from induced pluripotent stem cells (iPSC EVs) have immunoregulatory potential with the ability to alter the macrophage phenotype. Modulating the macrophage phenotype towards an anti-inflammatory, pro-resolvi…
View article: Genome-Wide Association Study of Quantitative Kidney Function in 52,531 Individuals with Diabetes Identifies Five Diabetes-Specific Loci
Genome-Wide Association Study of Quantitative Kidney Function in 52,531 Individuals with Diabetes Identifies Five Diabetes-Specific Loci Open
Key Points Comprehensive genome-wide association study of eGFR in diabetes, accounting for diabetes duration, kidney disease, and known modifiers, identified novel genetic effects. Incorporation of various kidney multi-omics data provides …
View article: A Novel Role for FERM Domain-Containing Protein 3 in CKD
A Novel Role for FERM Domain-Containing Protein 3 in CKD Open
Key Points We have identified a transcriptional signature of 93 genes associated with CKD severity and progression. Protein 4.1, ezrin, radixin, moesin domain-containing protein 3 gene expression is reduced in the context of more severe ki…
View article: Expression Proteomics and Histone Analysis Reveal Extensive Chromatin Network Changes and a Role for Histone Tail Trimming during Cellular Differentiation
Expression Proteomics and Histone Analysis Reveal Extensive Chromatin Network Changes and a Role for Histone Tail Trimming during Cellular Differentiation Open
In order to understand the coordinated proteome changes associated with differentiation of a cultured cell pluripotency model, protein expression changes induced by treatment of NT2 embryonal carcinoma cells with retinoic acid were monitor…
View article: Epigenome-wide meta-analysis identifies DNA methylation biomarkers associated with diabetic kidney disease
Epigenome-wide meta-analysis identifies DNA methylation biomarkers associated with diabetic kidney disease Open
Type 1 diabetes affects over nine million individuals globally, with approximately 40% developing diabetic kidney disease. Emerging evidence suggests that epigenetic alterations, such as DNA methylation, are involved in diabetic kidney dis…
View article: Genome-wide meta-analysis and omics integration identifies novel genes associated with diabetic kidney disease
Genome-wide meta-analysis and omics integration identifies novel genes associated with diabetic kidney disease Open
Background Diabetes is the leading cause of kidney disease, and heritability studies demonstrate a substantial, yet poorly understood, contribution of genetics to kidney complications in people with diabetes. Methods We performed genome-wi…
View article: Assessment of differentially methylated loci in individuals with end-stage kidney disease attributed to diabetic kidney disease: an exploratory study
Assessment of differentially methylated loci in individuals with end-stage kidney disease attributed to diabetic kidney disease: an exploratory study Open
Background A subset of individuals with type 1 diabetes mellitus (T1DM) are predisposed to developing diabetic kidney disease (DKD), the most common cause globally of end-stage kidney disease (ESKD). Emerging evidence suggests epigenetic c…
View article: Lipoxins and synthetic lipoxin mimetics: Therapeutic potential in renal diseases
Lipoxins and synthetic lipoxin mimetics: Therapeutic potential in renal diseases Open
Inflammation and its timely resolution are critical to ensuring effective host defence and appropriate tissue repair after injury. Unresolved inflammation typifies many renal pathologies. The key drivers of the inflammatory response are we…
View article: Additional file 1 of Assessment of differentially methylated loci in individuals with end-stage kidney disease attributed to diabetic kidney disease: an exploratory study
Additional file 1 of Assessment of differentially methylated loci in individuals with end-stage kidney disease attributed to diabetic kidney disease: an exploratory study Open
Additional file 1. Supplementary Tables.
View article: Assessment of differentially methylated loci in individuals with end-stage kidney disease attributed to diabetic kidney disease
Assessment of differentially methylated loci in individuals with end-stage kidney disease attributed to diabetic kidney disease Open
A subset of individuals with type 1 diabetes mellitus (T1DM) are predisposed to developing diabetic kidney disease (DKD), which is the most common cause globally of end-stage kidney disease (ESKD). Emerging evidence suggests epigenetic cha…
View article: Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen
Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen Open
Significance Statement Although studies show that diabetic kidney disease has a heritable component, searches for the genetic determinants of this complication of diabetes have had limited success. In this study, a new international genomi…
View article: Unravelling the transcriptional responses of TGF‐β: Smad3 and EZH2 constitute a regulatory switch that controls neuroretinal epithelial cell fate specification
Unravelling the transcriptional responses of TGF‐β: Smad3 and EZH2 constitute a regulatory switch that controls neuroretinal epithelial cell fate specification Open
Cell differentiation is directed by extracellular cues and intrinsic epigenetic modifications, which control chromatin organization and transcriptional activation. Central to this process is PRC2, which modulates the di‐ and trimethylation…
View article: Specialized Pro-resolving Lipid Mediators: Modulation of Diabetes-Associated Cardio-, Reno-, and Retino-Vascular Complications
Specialized Pro-resolving Lipid Mediators: Modulation of Diabetes-Associated Cardio-, Reno-, and Retino-Vascular Complications Open
Diabetes and its associated chronic complications present a healthcare challenge on a global scale. Despite improvements in the management of chronic complications of the micro-/macro-vasculature, their growing prevalence and incidence hig…
View article: miR302 regulates SNAI1 expression to control mesangial cell plasticity
miR302 regulates SNAI1 expression to control mesangial cell plasticity Open
Cell fate decisions are controlled by the interplay of transcription factors and epigenetic modifiers, which together determine cellular identity. Here we elaborate on the role of miR302 in the regulation of cell plasticity. Overexpression…
View article: Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells
Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells Open
Polycomb proteins assemble to form complexes with important roles in epigenetic regulation. The Polycomb Repressive Complex 2 (PRC2) modulates the di- and tri-methylation of lysine 27 on histone H3, each of which are associated with gene r…
View article: Wnt6 regulates epithelial cell differentiation and is dysregulated in renal fibrosis
Wnt6 regulates epithelial cell differentiation and is dysregulated in renal fibrosis Open
Diabetic nephropathy is the most common microvascular complication of diabetes mellitus, manifesting as mesangial expansion, glomerular basement membrane thickening, glomerular sclerosis, and progressive tubulointerstitial fibrosis leading…