Darren J. Obbard
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View article: Estimating the additive genetic variance for relative fitness from changes in allele frequency
Estimating the additive genetic variance for relative fitness from changes in allele frequency Open
The rate of adaptation is equal to the additive genetic variance for relative fitness (VA) in the population. Estimating VA typically involves obtaining suitable measures of fitness on a large number of individuals with known pairwise rela…
View article: A diverse gut virome from Drosophila melanogaster
A diverse gut virome from Drosophila melanogaster Open
Background Drosophila melanogaster is not only one of the most important models of antiviral immunity in invertebrates, but is also a powerful model for research of the gut microbiome. Although recent studies have continued to improve our …
View article: Predictors of protein evolution in the drosophilid immune system
Predictors of protein evolution in the drosophilid immune system Open
The evolutionary dynamics of immune genes are shaped by diverse selective pressures, yet the relative roles of gene-level traits, functional specialization, and pathway context remain poorly understood. Here, we applied a meta-analytic mix…
View article: Footprints of Worldwide Adaptation in Structured Populations of <i>Drosophila melanogaster</i> Through the Expanded DEST 2.0 Genomic Resource
Footprints of Worldwide Adaptation in Structured Populations of <i>Drosophila melanogaster</i> Through the Expanded DEST 2.0 Genomic Resource Open
Large-scale genomic resources can place genetic variation into an ecologically informed context. To advance our understanding of the population genetics of the fruit fly Drosophila melanogaster, we present an expanded release of the commun…
View article: Transcriptomic analysis of non-model Drosophilidae reveals novel AMP candidates
Transcriptomic analysis of non-model Drosophilidae reveals novel AMP candidates Open
Background Drosophila melanogaster has been a valuable model for dissecting the molecular architecture of innate immunity. However, the family Drosophilidae encompasses over 4000 species, spanning deep evolutionary divergences and diverse …
View article: Transcriptomic analysis of non-model Drosophilidae reveals novel AMP candidates
Transcriptomic analysis of non-model Drosophilidae reveals novel AMP candidates Open
Background Drosophila melanogaster has been a valuable model for dissecting the molecular architecture of innate immunity. However, the family Drosophilidae encompasses over 4000 species, spanning deep evolutionary divergences and diverse …
View article: Estimating the additive genetic variance for relative fitness from changes in allele frequency
Estimating the additive genetic variance for relative fitness from changes in allele frequency Open
The rate of adaptation is equal to the additive genetic variance for relative fitness ( V A ) in the population. Estimating V A typically involves obtaining suitable measures of fitness on a large number of individuals with known pairwise …
View article: Variable prevalence of protective Spiroplasma infection over time in two natural populations of Drosophila hydei
Variable prevalence of protective Spiroplasma infection over time in two natural populations of Drosophila hydei Open
The temporal dynamics of protective symbionts have rarely been characterized outside of aphid hosts. Here, we determine the prevalence of Spiroplasma in two populations of Drosophila hydei where Spiroplasma infection had been previously re…
View article: Comparative gene annotation of 304 species of Drosophilidae
Comparative gene annotation of 304 species of Drosophilidae Open
High-quality genome annotations are essential if we are to address central questions in comparative genomics, such as the origin of new genes, the drivers of genome size variation, and the evolutionary forces shaping gene content and struc…
View article: Footprints of worldwide adaptation in structured populations of<i>D. melanogaster</i>through the expanded DEST 2.0 genomic resource
Footprints of worldwide adaptation in structured populations of<i>D. melanogaster</i>through the expanded DEST 2.0 genomic resource Open
Large scale genomic resources can place genetic variation into an ecologically informed context. To advance our understanding of the population genetics of the fruit fly Drosophila melanogaster , we present an expanded release of the commu…
View article: Variable prevalence of protective<i>Spiroplasma</i>infection over time in two natural populations of<i>Drosophila hydei</i>
Variable prevalence of protective<i>Spiroplasma</i>infection over time in two natural populations of<i>Drosophila hydei</i> Open
The temporal dynamics of protective symbionts have rarely been characterized outside of aphid hosts. Here, we determine the prevalence of Spiroplasma in two populations of D. hydei where Spiroplasma infection had been previously recorded (…
View article: The genome sequence of a drosophilid fruit fly, Drosophila helvetica Burla 1948
The genome sequence of a drosophilid fruit fly, Drosophila helvetica Burla 1948 Open
We present a genome assembly from an individual male Drosophila helvetica (drosophilid fruit fly; Arthropoda; Insecta; Diptera; Drosophilidae). The genome sequence spans 224.20 megabases. Most of the assembly is scaffolded into 6 chromosom…
View article: Single-fly genome assemblies fill major phylogenomic gaps across the Drosophilidae Tree of Life
Single-fly genome assemblies fill major phylogenomic gaps across the Drosophilidae Tree of Life Open
Long-read sequencing is driving rapid progress in genome assembly across all major groups of life, including species of the family Drosophilidae, a longtime model system for genetics, genomics, and evolution. We previously developed a cost…
View article: The genome sequence of a drosophilid fruit fly, Drosophila limbata von Roser 1840
The genome sequence of a drosophilid fruit fly, Drosophila limbata von Roser 1840 Open
We present a genome assembly from an individual male Drosophila limbata (drosophilid fruit fly; Arthropoda; Insecta; Diptera; Drosophilidae). The genome sequence is 233.5 megabases in span. Most of the assembly is scaffolded into 6 chromos…
View article: Naturally occurring viruses of <i>Drosophila</i> reduce offspring number and lifespan
Naturally occurring viruses of <i>Drosophila</i> reduce offspring number and lifespan Open
Drosophila remains a pre-eminent insect model system for host–virus interaction, but the host range and fitness consequences of the drosophilid virome are poorly understood. Metagenomic studies have reported approximately 200 viruses assoc…
View article: A diverse gut virome from<i>Drosophila melanogaster</i>
A diverse gut virome from<i>Drosophila melanogaster</i> Open
Drosophila melanogaster is not only one of the most important models of antiviral immunity in invertebrates, but is also a powerful model for research of the gut microbiome. Although recent studies have continued to improve our knowledge o…
View article: The genome sequence of the drosophilid fruit fly, Drosophila phalerata (Meigen, 1830)
The genome sequence of the drosophilid fruit fly, Drosophila phalerata (Meigen, 1830) Open
We present a genome assembly from an individual male Drosophila phalerata (drosophilid fruit fly, Arthropoda; Insecta; Diptera; Drosophilidae). The genome sequence is 223.9 megabases in span. Most of the assembly is scaffolded into 7 chrom…
View article: The genome sequence of a drosophilid fruit fly, Drosophila histrio (Meigen, 1830)
The genome sequence of a drosophilid fruit fly, Drosophila histrio (Meigen, 1830) Open
We present a genome assembly from an individual female Drosophila histrio (the drosophilid fruit fly; Arthropoda; Insecta; Diptera; Drosophilidae). The genome sequence is 189.2 megabases in span. Most of the assembly is scaffolded into 5 c…
View article: Referee report. For: The genome sequence of the slender grass hoverfly, Melanostoma scalare (Fabricius, 1794) [version 1; peer review: 1 approved]
Referee report. For: The genome sequence of the slender grass hoverfly, Melanostoma scalare (Fabricius, 1794) [version 1; peer review: 1 approved] Open
View article: Referee report. For: The genome sequence of the common buff snailkiller, Tetanocera ferruginea (Fallén, 1820) [version 1; peer review: 1 approved]
Referee report. For: The genome sequence of the common buff snailkiller, Tetanocera ferruginea (Fallén, 1820) [version 1; peer review: 1 approved] Open
View article: Referee report. For: The genome sequence of a heleomyzid fly, Suillia variegata (Loew, 1862) [version 1; peer review: 1 approved]
Referee report. For: The genome sequence of a heleomyzid fly, Suillia variegata (Loew, 1862) [version 1; peer review: 1 approved] Open
View article: The genome sequence of a drosophilid fruit fly, Chymomyza fuscimana (Drosophilidae) (Zetterstedt, 1838)
The genome sequence of a drosophilid fruit fly, Chymomyza fuscimana (Drosophilidae) (Zetterstedt, 1838) Open
We present a genome assembly from an individual male Chymomyza fuscimana (drosophilid fruit fly; Arthropoda; Insecta; Diptera; Drosophilidae). The genome sequence is 338.0 megabases in span. Most of the assembly is scaffolded into 5 chromo…
View article: The genome sequence of a drosophilid fruit fly, Drosophila funebris (Fabricius, 1789)
The genome sequence of a drosophilid fruit fly, Drosophila funebris (Fabricius, 1789) Open
We present a genome assembly from an individual male Drosophila funebris (drosophilid fruit fly; Arthropoda; Insecta; Diptera; Drosophilidae). The genome sequence is 181.1 megabases in span. Most of the assembly is scaffolded into 7 chromo…
View article: Single-fly assemblies fill major phylogenomic gaps across the Drosophilidae Tree of Life
Single-fly assemblies fill major phylogenomic gaps across the Drosophilidae Tree of Life Open
Long-read sequencing is driving rapid progress in genome assembly across all major groups of life, including species of the family Drosophilidae, a longtime model system for genetics, genomics, and evolution. We previously developed a cost…
View article: Naturally occurring viruses of<i>Drosophila</i>reduce offspring number and lifespan
Naturally occurring viruses of<i>Drosophila</i>reduce offspring number and lifespan Open
Drosophila remains a pre-eminent insect model system for host-virus interaction, but the host range and fitness consequences of the drosophilid virome are poorly understood. Metagenomic studies have reported over 160 viruses associated wit…
View article: Viruses in Laboratory Drosophila and Their Impact on Host Gene Expression
Viruses in Laboratory Drosophila and Their Impact on Host Gene Expression Open
Drosophila melanogaster has one of the best characterized antiviral immune responses among invertebrates. However, relatively few easily transmitted natural virus isolates are available, and so many Drosophila experiments have been perform…
View article: The genome sequence of a drosophilid fruit fly, Hirtodrosophila cameraria (Haliday, 1833)
The genome sequence of a drosophilid fruit fly, Hirtodrosophila cameraria (Haliday, 1833) Open
We present a genome assembly from an individual female Hirtodrosophila cameraria (a drosophilid fruit fly; Arthropoda; Insecta; Diptera; Drosophilidae). The genome sequence is 214.5 megabases in span. Most of the assembly is scaffolded int…
View article: Viruses in laboratory<i>Drosophila</i>and their impact on host gene expression
Viruses in laboratory<i>Drosophila</i>and their impact on host gene expression Open
Drosophila melanogaster has one of the best characterized antiviral immune responses among invertebrates. However, relatively few easily-transmitted natural virus isolates are available, and so many Drosophila experiments have been perform…
View article: Experimental estimates of germline mutation rate in eukaryotes: a phylogenetic meta-analysis
Experimental estimates of germline mutation rate in eukaryotes: a phylogenetic meta-analysis Open
Mutation is the ultimate source of all genetic variation, and over the last 10 years the ready availability of whole-genome sequencing has permitted direct estimation of mutation rate for many non-model species across the tree of life. In …
View article: Variation in mutation, recombination, and transposition rates in <i>Drosophila melanogaster</i> and <i>Drosophila simulans</i>
Variation in mutation, recombination, and transposition rates in <i>Drosophila melanogaster</i> and <i>Drosophila simulans</i> Open
The rates of mutation, recombination, and transposition are core parameters in models of evolution. They impact genetic diversity, responses to ongoing selection, and levels of genetic load. However, even for key evolutionary model species…