Darren M. Roberts
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View article: Clinical implications of using different methods for estimating kidney function in older hospitalised patients: creatinine, cystatin C, or both
Clinical implications of using different methods for estimating kidney function in older hospitalised patients: creatinine, cystatin C, or both Open
Cystatin C is an emerging alternative to creatinine for estimating kidney function. Formulae using cystatin C may more accurately reflect glomerular filtration rate than those based on creatinine. We prospectively evaluated the impact of f…
View article: Emergency department presentations, hospitalisations and police seizure data related to gamma‐hydroxybutyrate (GHB) in New South Wales, Australia, from 2015 to 2024
Emergency department presentations, hospitalisations and police seizure data related to gamma‐hydroxybutyrate (GHB) in New South Wales, Australia, from 2015 to 2024 Open
Background and aims Gamma‐hydroxybutyrate (GHB) is an endogenous neurochemical and illicit synthetic drug. Its precursors, gamma‐butyrolactone (GBL) and 1,4‐butanediol (1,4‐BD), are often used as substitutes. We aimed to describe GHB‐relat…
View article: Tele-triaging: a qualitative study exploring pharmacists’ clinical decision-making in a Poisons Information Centre using interviews and a clinical vignette
Tele-triaging: a qualitative study exploring pharmacists’ clinical decision-making in a Poisons Information Centre using interviews and a clinical vignette Open
Introduction Specialists in Poisons Information (SPIs), most of whom are pharmacists, work in Australian Poisons Information Centres (PICs) and provide telephone-based triage (tele-triage) and management advice for poison exposures. Austra…
View article: Clinical Experiences With the Nitazene Class of Synthetic Opioids: A Cohort Study
Clinical Experiences With the Nitazene Class of Synthetic Opioids: A Cohort Study Open
This case series highlights that standard parenteral naloxone doses are typically effective, but ongoing monitoring is necessary to detect renarcotization. Nitazene opioids display novel consumption patterns, including exposure by vaping a…
View article: Hydromorphone Hopes: A Qualitative Study of People Initiating Supervised Short‐Acting Injectable Opioid Treatment in Australia
Hydromorphone Hopes: A Qualitative Study of People Initiating Supervised Short‐Acting Injectable Opioid Treatment in Australia Open
Introduction A growing body of qualitative scholarship has drawn attention to aspects of supervised injectable opioid treatment (SIOT) not captured in earlier clinical trial data, identifying treatment initiation as one such area. Crucial …
View article: Contents and Time‐Course of Falsified Alprazolam Detections in New South Wales, Australia
Contents and Time‐Course of Falsified Alprazolam Detections in New South Wales, Australia Open
Introduction Falsified alprazolam tablets (sometimes called ‘counterfeit alprazolam’) typically do not contain alprazolam and instead contain novel benzodiazepines or other drugs. We describe temporal changes in the number and contents of …
View article: Management of hypotension in dihydropyridine calcium channel blocker overdose: The role of high‐dose insulin therapy
Management of hypotension in dihydropyridine calcium channel blocker overdose: The role of high‐dose insulin therapy Open
Aims Amlodipine poisoning is a leading cause of cardiovascular medication‐related deaths, commonly managed with high‐dose insulin (HDI) therapy. However, HDI is a vasodilator that is counterproductive in managing vasoplegia. We aim to stud…
View article: Population Pharmacokinetic Modelling of Remdesivir and Its Metabolite GS-441524 in Hospitalised Patients with COVID-19
Population Pharmacokinetic Modelling of Remdesivir and Its Metabolite GS-441524 in Hospitalised Patients with COVID-19 Open
Background and Objectives There are limited data testing whether the licensed dose of remdesivir and its active metabolite GS-441524 achieve target concentrations in hospitalised patients with confirmed severe acute respiratory syndrome co…
View article: Trends in novel opioid use and detections in exposures and police drug seizures in New South Wales
Trends in novel opioid use and detections in exposures and police drug seizures in New South Wales Open
Introduction Novel opioids, including non‐medical and non‐opium‐based opioids such as fentanyl analogues and nitazenes, pose a significant risk of harm due to their high potency. There is little published data on novel opioid detections an…
View article: Opioid overdoses following use of cocaine and methamphetamine in <scp>New South Wales</scp>, and the public health responses
Opioid overdoses following use of cocaine and methamphetamine in <span>New South Wales</span>, and the public health responses Open
Objective Recent years have seen sporadic reports in Australia of stimulants being contaminated with opioids. Since late 2023, there has been an increase in opioid overdoses among individuals in New South Wales (NSW) using substances belie…
View article: Integrating International Consensus Guidelines for Anticancer Drug Dosing in Kidney Dysfunction (ADDIKD) into everyday practice
Integrating International Consensus Guidelines for Anticancer Drug Dosing in Kidney Dysfunction (ADDIKD) into everyday practice Open
View article: Aligning kidney function assessment in patients with cancer to global practices in internal medicine
Aligning kidney function assessment in patients with cancer to global practices in internal medicine Open
View article: Bridging the evidence and the politics: Implementation trial of supervised injectable opioid treatment (SIOT) in Australia
Bridging the evidence and the politics: Implementation trial of supervised injectable opioid treatment (SIOT) in Australia Open
View article: Implementation of time-limited parenteral hydromorphone in people with treatment-resistant injecting opioid use disorder: a protocol for a single-site, uncontrolled, open-label study to assess feasibility, safety and cost
Implementation of time-limited parenteral hydromorphone in people with treatment-resistant injecting opioid use disorder: a protocol for a single-site, uncontrolled, open-label study to assess feasibility, safety and cost Open
Introduction Supervised injectable opioid treatment (SIOT) is an evidence-based intervention targeting opioid-dependent people for whom existing treatments have been ineffective. This project will primarily assess the feasibility and the a…
View article: Abstracts of the Toxicology and Poisons Network Australasia (TAPNA) 2024 Annual Scientific Meeting (Melbourne, Victoria).
Abstracts of the Toxicology and Poisons Network Australasia (TAPNA) 2024 Annual Scientific Meeting (Melbourne, Victoria). Open
Background Toxic alcohol poisoning is uncommon in New South Wales (NSW). Inadequate treatment causes significant morbidity and mortality. Management priorities are diagnosis, and early treatment with alcohol dehydrogenase (ADH) blockade an…
View article: Economic evaluations of therapeutic drug monitoring interventions in acute hospital‐based settings: A systematic review
Economic evaluations of therapeutic drug monitoring interventions in acute hospital‐based settings: A systematic review Open
Aims Therapeutic drug monitoring (TDM) aims to optimize drug therapy. As demand on health resources increases, and the technology underpinning TDM becomes more sophisticated, the economic benefits of TDM in hospitals is unclear. The aim of…
View article: Trends in reported <scp>GHB</scp>‐related presentations to Sydney emergency departments between 2012 and 2021
Trends in reported <span>GHB</span>‐related presentations to Sydney emergency departments between 2012 and 2021 Open
Objectives In overdose, gamma‐hydroxybutyrate (GHB) and its precursors can cause decreased levels of consciousness, coma and death. Here, we aim to describe reported exposure to GHB at four EDs in Sydney, New South Wales (NSW), Australia. …
View article: Clinical utilities and end-user experience of pharmacogenomics: 39 mo of clinical implementation experience in an Australian hospital setting
Clinical utilities and end-user experience of pharmacogenomics: 39 mo of clinical implementation experience in an Australian hospital setting Open
BACKGROUND Pharmacogenomics (PG) testing is under-utilised in Australia. Our research provides Australia-specific data on the perspectives of patients who have had PG testing and those of the clinicians involved in their care, with the aim…
View article: Understandings, attitudes, practices and responses to GHB overdose among GHB consumers
Understandings, attitudes, practices and responses to GHB overdose among GHB consumers Open
View article: The danger of the toxicity and inefficacy of alcohol-based hand rubs in Iran during COVID-19: a cross-sectional study
The danger of the toxicity and inefficacy of alcohol-based hand rubs in Iran during COVID-19: a cross-sectional study Open
Background The use of disinfectants and alcohol-based hand rubs (ABHR) to prevent COVID-19 transmission increased in the first wave of the infection. To meet the increased demand, the Iranian Ministry of Health issued an emergency use auth…
View article: Extracorporeal treatment for ethylene glycol poisoning: systematic review and recommendations from the EXTRIP workgroup
Extracorporeal treatment for ethylene glycol poisoning: systematic review and recommendations from the EXTRIP workgroup Open
Ethylene glycol (EG) is metabolized into glycolate and oxalate and may cause metabolic acidemia, neurotoxicity, acute kidney injury (AKI), and death. Historically, treatment of EG toxicity included supportive care, correction of acid–base …
View article: Long‐term patterns in ecosystem phenology near Palmer Station, Antarctica, from the perspective of the Adélie penguin
Long‐term patterns in ecosystem phenology near Palmer Station, Antarctica, from the perspective of the Adélie penguin Open
Climate change is leading to phenological shifts across a wide range of species globally. Polar oceans are hotspots of rapid climate change where sea ice dynamics structure ecosystems and organismal life cycles are attuned to ice seasonali…
View article: Management of Poisonings and Intoxications
Management of Poisonings and Intoxications Open
Poisoning occurs after exposure to any of a number of substances, including medicines, which can result in severe toxicity including death. The nephrologist may be involved in poisonings that cause kidney disease and for targeted treatment…
View article: Inpatient GHB withdrawal management in an inner-city hospital in Sydney, Australia: a retrospective medical record review
Inpatient GHB withdrawal management in an inner-city hospital in Sydney, Australia: a retrospective medical record review Open
View article: Evaluating new simplified assays for harm reduction from methanol poisoning using chromotropic acid kits: An analytical study on Indian and Iranian alcoholic beverages
Evaluating new simplified assays for harm reduction from methanol poisoning using chromotropic acid kits: An analytical study on Indian and Iranian alcoholic beverages Open
Background Ingestion of methanol can result in severe irreversible morbidity, and death. Simple and easy methods to detect methanol and other hazardous additives prior to consumption can prevent fatalities. This form of harm reduction is a…
View article: Extracorporeal Treatment for Methotrexate Poisoning: Systematic Review and Recommendations from the EXTRIP Workgroup.
Extracorporeal Treatment for Methotrexate Poisoning: Systematic Review and Recommendations from the EXTRIP Workgroup. Open
Methotrexate is used in the treatment of many malignancies, rheumatological diseases, and inflammatory bowel disease. Toxicity from use is associated with severe morbidity and mortality. Rescue treatments include intravenous hydration, fol…
View article: Extracorporeal Treatment for Methotrexate Poisoning
Extracorporeal Treatment for Methotrexate Poisoning Open
Methotrexate is used in the treatment of many malignancies, rheumatological diseases, and inflammatory bowel disease. Toxicity from use is associated with severe morbidity and mortality. Rescue treatments include intravenous hydration, fol…
View article: Extracorporeal Treatment for Gabapentin and Pregabalin Poisoning: Systematic Review and Recommendations From the EXTRIP Workgroup
Extracorporeal Treatment for Gabapentin and Pregabalin Poisoning: Systematic Review and Recommendations From the EXTRIP Workgroup Open
View article: Letter to the editor: Intermittent high-efficiency hemodialysis remains preferable to CKRT in late ethylene glycol poisoning
Letter to the editor: Intermittent high-efficiency hemodialysis remains preferable to CKRT in late ethylene glycol poisoning Open
View article: The National Paediatric Medicines Forum: Who we are and what are we doing
The National Paediatric Medicines Forum: Who we are and what are we doing Open
An increasing understanding of the pathophysiology of complex diseases has contributed to the explosion in availability of newer medications in recent years. Newer medications frequently have more specific mechanisms of action and improved…