Explanipedia

Left ventricular dysfunction in potential heart donors after brain death: When is it reversible? Open

Brian Wayda, Helen Luikart, Yingjie Weng, S. Zhang, Bruce Nicely , et al. · 2025

Patient perceptions of and experiences with stigma using telehealth for opioid use disorder treatment: a qualitative analysis Open

Jessica V. Couch, Mackenzie Whitcomb, Bradley M. Buchheit, David A Dorr, Darren Malinoski , et al. · 2024

Therapeutic Hypothermia in Low-Risk Nonpumped Brain-Dead Kidney Donors Open

Madhukar S. Patel, Juan D. Salcedo Betancourt, Christina Saunders, Kristine Broglio, Darren Malinoski , et al. · 2024

Importance Delayed graft function in kidney-transplant recipients is associated with increased financial cost and patient burden. In donors with high Kidney Donor Profile Index whose kidneys are not pumped, therapeutic hypothermia has been…

Prediction of donor heart acceptance for transplant and its clinical implications – results from the Donor Heart Study Open

Brian Wayda, Yingjie Weng, Shiqi Zhang, Helen Luikart, Thomas Pearson , et al. · 2023

Background Despite a shortage of potential donors for heart transplant in the United States (US), most potential donor hearts are discarded. We evaluated predictors of donor heart acceptance in the US and applied modern analytic methods to…

Left Ventricular Dysfunction Associated With Brain Death: Results From the Donor Heart Study Open

Kiran K. Khush, Darren Malinoski, Helen Luikart, Brian Wayda, Tahnee Groat , et al. · 2023

BACKGROUND: Left ventricular dysfunction in potential donors meeting brain death criteria often results in nonuse of donor hearts for transplantation, yet little is known about its incidence or pathophysiology. Resolving these unknowns was…

Molecular Mechanisms of Rhabdomyolysis-Induced Kidney Injury: From Bench to Bedside Open

Jessica F. Hebert, Kevin G. Burfeind, Darren Malinoski, Michael P. Hutchens · 2022

Challenges encountered in conducting donor-based research: Lessons learned from the Donor Heart Study Open

Kiran K. Khush, Helen Luikart, Nikole Neidlinger, Ahmad Salehi, John Nguyen , et al. · 2022

Machine Learning Prediction of Liver Allograft Utilization From Deceased Organ Donors Using the National Donor Management Goals Registry Open

Andrew Bishara, Dmytro Lituiev, Dieter Adelmann, Rishi Kothari, Darren Malinoski , et al. · 2021

Background. Early prediction of whether a liver allograft will be utilized for transplantation may allow better resource deployment during donor management and improve organ allocation. The national donor management goals (DMG) registry co…

Critical care and ventilatory management of deceased organ donors impact lung use and recipient graft survival Open

Elizabeth A. Swanson, Madhukar S. Patel, Michael P. Hutchens, Claus U. Niemann, Tahnee Groat , et al. · 2021

Impact of Deceased Donor Management on Donor Heart Use and Recipient Graft Survival Open

Elizabeth A. Swanson, Tony Adams, Madhukar S. Patel, Salvador De La Cruz, Michael P. Hutchens , et al. · 2020

Modifiable critical care parameters and treatments predict donor heart use and cardiac graft survival. The discordant relationship between thyroid hormone and donor heart use (negative predictor) vs cardiac graft survival (positive predict…

Vasopressor selection during critical care management of brain dead organ donors and the effects on kidney graft function Open

Elizabeth A. Swanson, Madhukar S. Patel, Tahnee Groat, Nora E. Jameson, Margaret K. M. Ellis , et al. · 2020

BACKGROUND Delayed graft function (DGF), the need for dialysis in the first week following kidney transplant, affects approximately one quarter of deceased-donor kidney transplant recipients. Donor demographics, donor serum creatinine, and…

Deceased organ donor factors influencing pancreatic graft transplantation and survival Open

Mitchell B. Sally, Margaret K. Menzel Ellis, Michael P. Hutchens, Tahnee Groat, Elizabeth A. Swanson , et al. · 2019

Criteria for organ acceptance in brain‐dead organ donors remain inconsistent, especially when concerning pancreatic transplants. We sought to examine donor‐specific predictors of pancreatic graft use and survival to better guide the select…

The Impact of Therapeutic Hypothermia Used to Treat Anoxic Brain Injury After Cardiopulmonary Resuscitation on Organ Donation Outcomes Open

Charles J. Wright, Madhukar S. Patel, Xiang Gao, M.A. Witt, Mitchell B. Sally , et al. · 2019

Therapeutic hypothermia (TH) is clinically used to improve neurologic outcomes in patients with anoxic brain injury after cardiopulmonary resuscitation (CPR). For patients that regress and become organ donors after neurologic determination…

A porcine model to study the effect of brain death on kidney genomic responses Open

Mitchell B. Sally, Darren Malinoski, Frank Zaldivar, Tony Le, Matin Khoshnevis , et al. · 2018

Introduction A majority of transplanted organs come from donors after brain death (BD). Renal grafts from these donors have higher delayed graft function and lower long-term survival rates compared to living donors. We designed a novel por…

Regional Variation in Utilization and Outcomes of Liver Allografts From Donors With High Body Mass Index and Graft Macrosteatosis: A Role for Liver Biopsy Open

Justin Steggerda, Irene Kim, Darren Malinoski, Andrew S. Klein, Matthew B. Bloom · 2018

Background Obesity, defined as a high body mass index (hBMI) of 30 kg/m 2 or greater, is a growing epidemic worldwide and is associated with multiple comorbidities. High BMI individuals account for an increasing portion of potential liver …

Comments on “Impact of spontaneous donor hypothermia on graft outcomes after kidney transplantation” Open

Claus U. Niemann, Kristine Broglio, Darren Malinoski · 2017

To the Editor Using a retrospective cohort that was part of a donor intervention trial published in 2009,1Schnuelle P Gottmann U Hoeger S et al.Effects of donor pretreatment with dopamine on graft function after kidney transplantation: A r…

The development and current status of Intensive Care Unit management of prospective organ donors Open

Margaret K. M. Ellis, Mitchell B. Sally, Darren Malinoski · 2016

Management of deceased organ donors should focus first on maintaining adequate perfusion to all organ systems through adherence to standard critical care guidelines, early referral to OPOs, and family support. Furthermore, several specific…

Therapeutic Hypothermia in Deceased Organ Donors and Kidney-Graft Function Open

Claus U. Niemann, John Feiner, Sharon Swain, Scott Bunting, Melissa Friedman , et al. · 2015

Mild hypothermia, as compared with normothermia, in organ donors after declaration of death according to neurologic criteria significantly reduced the rate of delayed graft function among recipients. (Funded by the Health Resources and Ser…

The Impact of Hydroxyethyl Starch Use in Deceased Organ Donors on the Development of Delayed Graft Function in Kidney Transplant Recipients: A Propensity-Adjusted Analysis Open

Madhukar S. Patel, Claus U. Niemann, Mitchell B. Sally, Salvador De La Cruz, John R. Zatarain , et al. · 2015

Our objective was to evaluate the impact of hydroxyethyl starch (HES) use in organ donors after neurologic determination of death (DNDD) on recipient renal graft outcomes. The following data elements were prospectively collected for every …

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