Darren Mylotte
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View article: Alternative Access for TAVR
Alternative Access for TAVR Open
Current guideline recommendations for transcatheter aortic valve replacement are largely confined to procedures performed via transfemoral (TF) access. Major advances in preprocedural planning, delivery system technology, and procedural te…
View article: 75 Comparison of procedural outcomes between sirolimus- and paclitaxel-drug-coated balloons in de novo coronary lesion angioplasty at index procedure and at 30-day follow-up
75 Comparison of procedural outcomes between sirolimus- and paclitaxel-drug-coated balloons in de novo coronary lesion angioplasty at index procedure and at 30-day follow-up Open
View article: 31 Outcomes and aortic regurgitation graded by videodensitometry from early neo2 & Neo2BAV registries
31 Outcomes and aortic regurgitation graded by videodensitometry from early neo2 & Neo2BAV registries Open
View article: Long‐Term Durability of Transcatheter Aortic Valves in Patients With Bicuspid Aortic Stenosis
Long‐Term Durability of Transcatheter Aortic Valves in Patients With Bicuspid Aortic Stenosis Open
Background Data concerning the long‐term durability of transcatheter aortic valves (TAVs) in patients with bicuspid aortic stenosis (AS) are lacking. Aims The study aims to report data on long‐term valve durability following transcatheter …
View article: Global Results From the Optimize PRO Study: Standardized TAVR Technique and Care Pathway
Global Results From the Optimize PRO Study: Standardized TAVR Technique and Care Pathway Open
View article: Intravascular Ultrasound Assessment of Coronary Arteries at High Risk for Obstruction Following TAVR
Intravascular Ultrasound Assessment of Coronary Arteries at High Risk for Obstruction Following TAVR Open
This first multicenter investigation on the IVUS use in the setting of CAO during TAVR suggests that the technique is both feasible and safe. Implementing IVUS in decision making on the need for chimney stenting may provide additional info…
View article: Clinical Impact of Midframe Underexpansion Following TAVR Using a Self-Expanding Transcatheter Heart Valve
Clinical Impact of Midframe Underexpansion Following TAVR Using a Self-Expanding Transcatheter Heart Valve Open
In this European cohort of ACURATE neo2 recipients, midframe underexpansion occurred in a minor proportion and was associated with poorer clinical outcomes through 1 year. Postdilatation effectively reduced the rate and extent of midframe …
View article: Rationale and design of the prevail global trial program evaluating the prevail drug-coated balloon in patients with in-stent restenosis and de novo small vessel disease
Rationale and design of the prevail global trial program evaluating the prevail drug-coated balloon in patients with in-stent restenosis and de novo small vessel disease Open
Prevail Global, NCT06535854, is registered at https://clinicaltrials.gov/study/NCT06535854.
View article: Incidence and predictors of continued ascending aortic dilatation after TAVI in patients with bicuspid aortic stenosis
Incidence and predictors of continued ascending aortic dilatation after TAVI in patients with bicuspid aortic stenosis Open
Background Patients undergoing transcatheter aortic valve implantation (TAVI) for bicuspid aortic stenosis (AS) frequently present with ascending aortic (AAo) dilatation which is left untreated. The objective of this study was to study the…
View article: Paclitaxel‐coated versus sirolimus‐coated balloon angioplasty for coronary artery disease: A systematic review and meta‐analysis
Paclitaxel‐coated versus sirolimus‐coated balloon angioplasty for coronary artery disease: A systematic review and meta‐analysis Open
Background Although use of sirolimus‐based analogs has shown superiority over paclitaxel in drug‐eluting stents, the relative efficacy of these two agents released from drug‐coated balloons (DCB) is unclear. The present meta‐analysis is ai…
View article: Characterization and Management of Stable Coronary Artery Disease in Patients Undergoing Transcatheter Aortic Valve Implantation
Characterization and Management of Stable Coronary Artery Disease in Patients Undergoing Transcatheter Aortic Valve Implantation Open
Background/Objectives: To date, data regarding the characteristics and management of obstructive, stable coronary artery disease (CAD) encountered in patients undergoing transcatheter aortic valve implantation (TAVI) are sparse. The aim of…
View article: Incidence, Predictors, and Outcomes of Paravalvular Regurgitation After TAVR in Sievers Type 1 Bicuspid Aortic Valves
Incidence, Predictors, and Outcomes of Paravalvular Regurgitation After TAVR in Sievers Type 1 Bicuspid Aortic Valves Open
View article: Defining high bleeding risk in patients undergoing transcatheter aortic valve implantation: a VARC-HBR consensus document
Defining high bleeding risk in patients undergoing transcatheter aortic valve implantation: a VARC-HBR consensus document Open
The identification and management of patients at high bleeding risk (HBR) undergoing transcatheter aortic valve implantation (TAVI) are of major importance, but the lack of standardised definitions is challenging for trial desi…
View article: Outcomes and predictors of left ventricle recovery in patients with severe left ventricular dysfunction undergoing transcatheter aortic valve implantation
Outcomes and predictors of left ventricle recovery in patients with severe left ventricular dysfunction undergoing transcatheter aortic valve implantation Open
LV recovery following TAVI and the extent of this recovery are major determinants of midterm mortality in patients with severe AS and severe LV dysfunction undergoing TAVI. Patients with no previous MI and those with an mAVG >40 mmHg show …
View article: Final report of the PROTEMBO C Trial: a prospective evaluation of a novel cerebral protection device during TAVI
Final report of the PROTEMBO C Trial: a prospective evaluation of a novel cerebral protection device during TAVI Open
View article: One-year clinical outcomes of transcatheter aortic valve implantation with the latest iteration of self-expanding or balloonexpandable devices: insights from the OPERA-TAVI registry
One-year clinical outcomes of transcatheter aortic valve implantation with the latest iteration of self-expanding or balloonexpandable devices: insights from the OPERA-TAVI registry Open
One-year clinical outcomes of patients undergoing transfemoral TAVI and receiving PRO or ULTRA devices in the current clinical practice were similar, but PRO patients had higher rates of disabling stroke. Outcomes did not differ across the…
View article: Periprocedural continuation versus interruption of oral anticoagulant drugs during transcatheter aortic valve implantation: rationale and design of the POPular PAUSE TAVI trial
Periprocedural continuation versus interruption of oral anticoagulant drugs during transcatheter aortic valve implantation: rationale and design of the POPular PAUSE TAVI trial Open
About one-third of patients undergoing transcatheter aortic valve implantation (TAVI) use oral anticoagulants (OAC), mainly due to atrial fibrillation. General guidelines advise interrupting OAC in patients with a high risk of bleeding und…
View article: 9 A prospective, randomized, non-inferiority trial to determine the safety and efficacy of the biolimus A9™ drug coated balloon for the treatment of in-stent restenosis: first-in-man trial (REFORM)
9 A prospective, randomized, non-inferiority trial to determine the safety and efficacy of the biolimus A9™ drug coated balloon for the treatment of in-stent restenosis: first-in-man trial (REFORM) Open
Background Drug-coated balloon (DCB) angioplasty with paclitaxel-eluting devices is an established treatment for coronary in-stent restenosis (ISR). Biolimus A9™ (BA9), a sirolimus analogue with enhanced lipophilicity, may facilitate enhan…
View article: 15 The clinical utility of biomarkers in transcatheter aortic valve implantation – insights from the gravity registry
15 The clinical utility of biomarkers in transcatheter aortic valve implantation – insights from the gravity registry Open
Introduction Biomarkers form key components of patient surveillance. Previous studies report associations between biomarkers and both disease severity and outcomes. Several biomarkers are part of the routine care of aortic stenosis (AS) pa…
View article: 40 Stent failure in a tertiary referral centre: a single centre retrospective cohort study
40 Stent failure in a tertiary referral centre: a single centre retrospective cohort study Open
Introduction Stent failure and particularly in-stent restenosis (ISR) remains a common presentation following percutaneous coronary intervention (PCI). Reported data suggests rates of up to 30% following bare metal stenting and 5–10% follo…
View article: 10 Clinical characteristics, procedural and short term outcomes for patients undergoing calcium modification using intravascular lithotripsy in a tertiary referral centre: a single centre retrospective analysis
10 Clinical characteristics, procedural and short term outcomes for patients undergoing calcium modification using intravascular lithotripsy in a tertiary referral centre: a single centre retrospective analysis Open
Introduction Calcified coronary artery disease continues to present significant challenges when performing percutaneous coronary intervention. Recently, intravascular lithotripsy (IVL) has been introduced into the interventionalist's armam…
View article: 58 A single centre cohort study to evaluate the prevalence and outcomes of concomitant aortic stenosis and suspected cardiac amyloidosis – insights from the gravity registry
58 A single centre cohort study to evaluate the prevalence and outcomes of concomitant aortic stenosis and suspected cardiac amyloidosis – insights from the gravity registry Open
Background Cardiac amyloidosis (CA) is an infiltrative process characterised by myocardial deposition of amyloid fibrils. Transthyretin (ATTR) is one of two major amyloid proteins seen in this condition, whose deposition in ventricular myo…
View article: Patient‐specific commissural alignment for ACURATE <i>neo2</i> implantation in degenerated surgical bioprostheses
Patient‐specific commissural alignment for ACURATE <i>neo2</i> implantation in degenerated surgical bioprostheses Open
Valve‐in‐valve TAVI to treat failing surgical aortic valves (SAVs) is increasingly performed, and commissural alignment is a key technical aspect in such procedures. Surgeons optimize valve alignment, accounting for potential coronary ecce…
View article: Sex-Related Outcomes of Transcatheter Aortic Valve Implantation with Self-Expanding or Balloon-Expandable Valves: Insights from the OPERA-TAVI Registry
Sex-Related Outcomes of Transcatheter Aortic Valve Implantation with Self-Expanding or Balloon-Expandable Valves: Insights from the OPERA-TAVI Registry Open
Background Evidence regarding sex-related differences in response to transcatheter aortic valve implantation according to the valve type is lacking. This study sought to evaluate the impact of sex on the treatment effect of Evolut-PRO/PRO+…
View article: Cerebral embolic protection during transcatheter heart interventions
Cerebral embolic protection during transcatheter heart interventions Open
Stroke remains a devastating complication of transcatheter aortic valve replacement (TAVR), with the incidence of clinically apparent stroke seemingly fixed at around 3% despite TAVR's significant evolution during the past decade. Embolic …
View article: Comparison of different percutaneous revascularisation timing strategies in patients undergoing transcatheter aortic valve implantation
Comparison of different percutaneous revascularisation timing strategies in patients undergoing transcatheter aortic valve implantation Open
In patients with severe aortic stenosis and stable coronary artery disease scheduled for TAVI, performance of PCI after TAVI seems to be associated with improved 2-year clinical outcomes compared with other revascularisation timing strateg…
View article: OCT or Angiography Guidance for PCI in Complex Bifurcation Lesions
OCT or Angiography Guidance for PCI in Complex Bifurcation Lesions Open
Among patients with complex coronary-artery bifurcation lesions, OCT-guided PCI was associated with a lower incidence of MACE at 2 years than angiography-guided PCI. (Funded by Abbott Vascular and others; OCTOBER ClinicalTrials.gov number,…
View article: Contemporary European practice in transcatheter aortic valve implantation: results from the 2022 European TAVI Pathway Registry
Contemporary European practice in transcatheter aortic valve implantation: results from the 2022 European TAVI Pathway Registry Open
Background A steep rise in the use of transcatheter aortic valve implantation (TAVI) for the management of symptomatic severe aortic stenosis occurred. Minimalist TAVI procedures and streamlined patient pathways within experienced Heart Va…
View article: Transcatheter aortic valve implantation with the Evolut platform for bicuspid aortic valve stenosis: the international, multicentre, prospective BIVOLUTX registry
Transcatheter aortic valve implantation with the Evolut platform for bicuspid aortic valve stenosis: the international, multicentre, prospective BIVOLUTX registry Open
BIVOLUTX demonstrated a favourable bioprosthetic valve performance and good clinical outcomes after TAVI with the Evolut platform in patients with bicuspid aortic stenosis. No impact from the sizing methodology could be identified.
View article: Predictors of Conduction Disturbances Requiring New Permanent Pacemaker Implantation following Transcatheter Aortic Valve Implantation Using the Evolut Series
Predictors of Conduction Disturbances Requiring New Permanent Pacemaker Implantation following Transcatheter Aortic Valve Implantation Using the Evolut Series Open
(1) Background: Conduction disturbance requiring a new permanent pacemaker (PPM) after transcatheter aortic valve implantation (TAVI) has traditionally been a common complication. New implantation techniques with self-expanding platforms h…