Darren Thifault
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View article: Structure-based discovery of hydrocarbon-stapled paxillin peptides that block FAK scaffolding in cancer
Structure-based discovery of hydrocarbon-stapled paxillin peptides that block FAK scaffolding in cancer Open
The focal adhesion kinase (FAK) scaffold provides FAK-targeted cancer therapeutics with greater efficacy and specificity than traditional kinase inhibitors. The FAK scaffold function largely involves the interaction between FAK’s focal adh…
View article: Electrically stimulated droplet injector for reduced sample consumption in serial crystallography
Electrically stimulated droplet injector for reduced sample consumption in serial crystallography Open
With advances in X-ray free-electron lasers (XFELs), serial femtosecond crystallography (SFX) has enabled the static and dynamic structure determination for challenging proteins such as membrane protein complexes. In SFX with XFELs, the cr…
View article: New structural insights into the function of the catalytically active human Taspase1
New structural insights into the function of the catalytically active human Taspase1 Open
Taspase1 is an Ntn-hydrolase overexpressed in primary human cancers, coordinating cancer 33Tcell proliferation, invasion, and metastasis.L33Toss of Taspase1 activity disrupts proliferation of human cancer cells in vitro and in mouse models…
View article: New Structural Insights into the Function of the Catalytically Active Human Taspase1
New Structural Insights into the Function of the Catalytically Active Human Taspase1 Open
Proteases can play essential roles in severe human pathology, ranging from degenerative and inflammatory illnesses to infectious diseases, with some, such as Taspase1, involved in growth and progression of tumors at primary and metastatic …
View article: Segmented flow generator for serial crystallography at the European X-ray free electron laser
Segmented flow generator for serial crystallography at the European X-ray free electron laser Open
Serial femtosecond crystallography (SFX) with X-ray free electron lasers (XFELs) allows structure determination of membrane proteins and time-resolved crystallography. Common liquid sample delivery continuously jets the protein crystal sus…