Darren Wong
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View article: Teduglutide in adults with short bowel syndrome and intestinal failure: A descriptive cohort study
Teduglutide in adults with short bowel syndrome and intestinal failure: A descriptive cohort study Open
Background International evidence supports the efficacy of teduglutide in reducing parenteral support requirements, or achieving enteral autonomy, in patients with short bowel syndrome–intestinal failure. This is a multicenter observationa…
View article: Rifaximin-α use is associated with improved muscle mass in patients with cirrhosis
Rifaximin-α use is associated with improved muscle mass in patients with cirrhosis Open
BACKGROUND Sarcopaenia is associated with a two-fold higher mortality rate in patients with cirrhosis independent of liver disease severity. Few treatments for cirrhosis related sarcopaenia exist beyond optimal nutritional management. AIM …
View article: Multi-omics evaluation of peritoneal fluid in gastroesophageal cancer (OMEGCA): protocol for a prospective multicentre cohort study to detect occult peritoneal metastases in patients undergoing curative-intent treatment
Multi-omics evaluation of peritoneal fluid in gastroesophageal cancer (OMEGCA): protocol for a prospective multicentre cohort study to detect occult peritoneal metastases in patients undergoing curative-intent treatment Open
Introduction Early detection of peritoneal disease, especially micro-metastases, in patients with gastroesophageal adenocarcinoma is critical as it alters therapeutic intent, providing a vital opportunity to personalise treatment. However,…
View article: History of intestinal transplantation in Australia
History of intestinal transplantation in Australia Open
Intestinal transplantation was introduced into Australia in 2010 to meet the need of a small number of patients with irreversible intestinal failure who would otherwise need to travel abroad to access this life-saving therapy. Due to small…
View article: Teduglutide Therapy in Short Bowel Syndrome – Intestinal Failure: A Multi-Centre Australian Real-World Observational Study
Teduglutide Therapy in Short Bowel Syndrome – Intestinal Failure: A Multi-Centre Australian Real-World Observational Study Open
View article: Unlocking Opportunities: A Review of Organ Donor Offers to the Australian Intestinal Transplant Service—What Are We Missing?
Unlocking Opportunities: A Review of Organ Donor Offers to the Australian Intestinal Transplant Service—What Are We Missing? Open
View article: Central Line Tip Positioning for Inpatient Parenteral Nutrition Administration: A Tertiary Hospital Audit
Central Line Tip Positioning for Inpatient Parenteral Nutrition Administration: A Tertiary Hospital Audit Open
View article: Measuring energy expenditure in intestinal failure: Ensuring the right bag at the right time
Measuring energy expenditure in intestinal failure: Ensuring the right bag at the right time Open
View article: Micronutrient Supplementation in Long Term Teduglutide, a Single Centre Experience
Micronutrient Supplementation in Long Term Teduglutide, a Single Centre Experience Open
View article: DEMENTIA CARE SHARED BY MULTIPLE CHINESE FAMILY CAREGIVERS: EXPLORING FAMILY-LEVEL PREPAREDNESS FOR CAREGIVING
DEMENTIA CARE SHARED BY MULTIPLE CHINESE FAMILY CAREGIVERS: EXPLORING FAMILY-LEVEL PREPAREDNESS FOR CAREGIVING Open
Involvement of multiple family members as caregivers is commonly observed and often essential in families living with dementia. While preparedness for caregiving was found to be associated with better caregiver outcomes, previous studies c…
View article: 754. PATHOLOGICAL RESPONSE PREDICTS EFFICACY OF ADJUVANT FLOT CHEMOTHERAPY IN GASTROESOPHAGEAL CANCER: AN INTERNATIONAL COHORT STUDY
754. PATHOLOGICAL RESPONSE PREDICTS EFFICACY OF ADJUVANT FLOT CHEMOTHERAPY IN GASTROESOPHAGEAL CANCER: AN INTERNATIONAL COHORT STUDY Open
Background Perioperative FLOT-based chemotherapy is the current standard of care for all patients with locally-advanced gastroesophageal cancer. However, many patients are unable to complete all planned adjuvant FLOT cycles due to treatmen…
View article: 254. QUANTIFYING PERIOPERATIVE RISKS FOR ANTIREFLUX AND HIATUS HERNIA SURGERY: A MULTICENTER COHORT STUDY OF 4301 PATIENTS
254. QUANTIFYING PERIOPERATIVE RISKS FOR ANTIREFLUX AND HIATUS HERNIA SURGERY: A MULTICENTER COHORT STUDY OF 4301 PATIENTS Open
Background Predicting perioperative risks for fundoplication and hiatus hernia repair will inform treatment decision-making, hospital resource allocation, and benchmarking. However, available risk calculators do not account for hernia anat…
View article: Statin, aspirin and metformin use and risk of hepatocellular carcinoma related outcomes following liver transplantation: A retrospective study
Statin, aspirin and metformin use and risk of hepatocellular carcinoma related outcomes following liver transplantation: A retrospective study Open
BACKGROUND Liver transplantation (LT) is a potentially curative therapy for patients with hepatocellular carcinoma (HCC). HCC-recurrence following LT is associated with reduced survival. There is increasing interest in chemoprophylaxis to …
View article: High stomal outputs following interactions between opioid and opioid-like derivatives with CYP inducers
High stomal outputs following interactions between opioid and opioid-like derivatives with CYP inducers Open
Background: International guidelines for the management of high output stoma (HOS) commonly involve the use of opioids and opioid-like derivatives, such as loperamide, to mitigate the risk or impact of intestinal failure. However, these ag…
View article: Funding and resource availability for home parenteral nutrition in Australia: A national cross‐sectional survey
Funding and resource availability for home parenteral nutrition in Australia: A national cross‐sectional survey Open
Background Home parenteral nutrition (HPN) is a life‐saving therapy required for the management of type III intestinal failure, one of the rarest organ failures. It requires a multidisciplinary approach to manage the complexity of the unde…
View article: Combination of anti-TNFα therapy and surgical resection for severe chronic intestinal rejection: A case report
Combination of anti-TNFα therapy and surgical resection for severe chronic intestinal rejection: A case report Open
Background: Acute cellular rejection (ACR) is a well-recognised cause of graft failure in intestinal transplant (ITx) recipients. Management of ACR is with intravenous (IV) steroids, increased immunosuppression and T-cell depleting therapi…
View article: Redefining Nutritional Requirements in End-Stage Liver Disease: Towards a Personalized Approach
Redefining Nutritional Requirements in End-Stage Liver Disease: Towards a Personalized Approach Open
Malnutrition is ubiquitous in cirrhotic patients presenting for liver transplant (LT). Providing an appropriate energy prescription is fundamental to effective nutrition therapy. We aimed to compare measured energy expenditure (mEE) with p…
View article: Effect of timing of perioperative chemical thromboprophylaxis on thromboembolic, bleeding, and other complications during and after antireflux surgery: multicentre cohort study
Effect of timing of perioperative chemical thromboprophylaxis on thromboembolic, bleeding, and other complications during and after antireflux surgery: multicentre cohort study Open
Background Although guidelines recommend the use of perioperative chemical thromboprophylaxis for antireflux surgery, the optimal timing for its initiation is unknown. The aim of this study was to investigate whether perioperative timing o…
View article: Evaluating treatment response following locoregional therapy for hepatocellular carcinoma: A review of the available serological and radiological tools for assessment
Evaluating treatment response following locoregional therapy for hepatocellular carcinoma: A review of the available serological and radiological tools for assessment Open
Hepatocellular carcinoma (HCC) is an aggressive primary malignancy of the liver and is the third most common cause of cancer‐related global mortality. There has been a steady increase in treatment options for HCC in recent years, including…
View article: P028 Transitioning patients from intravenous to subcutaneous infliximab and vedolizumab for inflammatory bowel disease – what is the opportunity cost of improving access to health care?
P028 Transitioning patients from intravenous to subcutaneous infliximab and vedolizumab for inflammatory bowel disease – what is the opportunity cost of improving access to health care? Open
Background Biologic drugs are highly effective for inflammatory bowel disease (IBD) management but are key drivers of costs of care especially when administered intravenously (IV). Availability of subcutaneous (SC) formulations has increas…
View article: Hepatitis B virus haplotype number at baseline is a predictive marker of functional cure during antiviral therapy for patients with genotypes A and D <scp>HBeAg</scp>‐positive chronic hepatitis B
Hepatitis B virus haplotype number at baseline is a predictive marker of functional cure during antiviral therapy for patients with genotypes A and D <span>HBeAg</span>‐positive chronic hepatitis B Open
Summary Backgrounds and Aims We investigated associations between hepatitis B virus (HBV) genome‐length haplotype number (HN) at baseline in subjects with HBeAg‐positive chronic hepatitis B (CHB), and the likelihood of achieving functional…
View article: External validation of a surgical mortality risk prediction model for inpatient noncardiac surgery in an Australian private health insurance dataset
External validation of a surgical mortality risk prediction model for inpatient noncardiac surgery in an Australian private health insurance dataset Open
Background We previously conducted a systematic review to identify surgical mortality risk prediction tools suitable for adapting in the Australian context and identified the Surgical Outcome Risk Tool (SORT) as an ideal model. The primary…
View article: Patient-reported Outcomes: the ICHOM Standard Set for Inflammatory Bowel Disease in Real-life Practice Helps Quantify Deficits in Current Care
Patient-reported Outcomes: the ICHOM Standard Set for Inflammatory Bowel Disease in Real-life Practice Helps Quantify Deficits in Current Care Open
Background Patient-reported outcome measures [PROMs] are key to documenting outcomes that matter most to patients and are increasingly important to commissioners of health care seeking value. We report the first series of the ICHOM Standar…
View article: Hospital costs and factors associated with days alive and at home after surgery ( <scp> DAH <sub>30</sub> </scp> )
Hospital costs and factors associated with days alive and at home after surgery ( <span> DAH <sub>30</sub> </span> ) Open
DAH30 is a validated, patient-centred outcome measure of post-surgical outcomes; higher values reflect shorter hospital stays and fewer serious complications, re-admissions, and deaths. DAH30 can be used to benchmark …
View article: Different factors limit early‐ and late‐season windows of opportunity for monarch development
Different factors limit early‐ and late‐season windows of opportunity for monarch development Open
Seasonal windows of opportunity are intervals within a year that provide improved prospects for growth, survival, or reproduction. However, few studies have sufficient temporal resolution to examine how multiple factors combine to constrai…
View article: COVID-19 pandemic impact on alcoholic hepatitis healthcare utilisation
COVID-19 pandemic impact on alcoholic hepatitis healthcare utilisation Open
View article: Moving computed tomography–based quantification of muscle mass to the mainstream: Validation of a web‐based platform to calculate skeletal muscle index in cirrhosis
Moving computed tomography–based quantification of muscle mass to the mainstream: Validation of a web‐based platform to calculate skeletal muscle index in cirrhosis Open
To the editor, Muscle wasting carries important prognostic value in patients with chronic liver disease.[1] Abdominal computed tomography (CT) or magnetic resonance imaging taken at the third lumbar vertebrae (L3) is generally considered t…
View article: Testosterone therapy reduces hepatic steatosis in men with type 2 diabetes and low serum testosterone concentrations
Testosterone therapy reduces hepatic steatosis in men with type 2 diabetes and low serum testosterone concentrations Open
Testosterone therapy was associated with a reduction in hepatic steatosis in men with diabetes and low serum testosterone. Future randomised studies of testosterone therapy in men with NAFLD focusing on liver-related endpoints are therefor…
View article: Early Versus Postoperative Chemical Thromboprophylaxis Is Associated with Increased Bleeding Risk Following Abdominal Visceral Resections: a Multicenter Cohort Study
Early Versus Postoperative Chemical Thromboprophylaxis Is Associated with Increased Bleeding Risk Following Abdominal Visceral Resections: a Multicenter Cohort Study Open
The risk of bleeding following elective abdominal visceral resections is substantial and is higher than the risk of clinical VTE. Compared with early chemoprophylaxis, postoperative initiation reduces bleeding risk without an increased ris…
View article: P594 Vedolizumab dose intensification does not always improve treatment persistence
P594 Vedolizumab dose intensification does not always improve treatment persistence Open
Background Vedolizumab is effective in inducing and maintaining remission in patients with both Crohn’s Disease (CD) and ulcerative colitis (UC). Recent data has demonstrated that there is superior persistence with vedolizumab compared to …