Darren Zuro
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View article: Targeted Irradiation and STAT3 Inhibition Reprogram the AML Microenvironment and Extend Survival: Toward Translational Immunoradiotherapy
Targeted Irradiation and STAT3 Inhibition Reprogram the AML Microenvironment and Extend Survival: Toward Translational Immunoradiotherapy Open
Purpose Despite advances in acute myeloid leukemia (AML) therapy, relapses remain challenging. While AML is radiation-sensitive, total body irradiation (TBI) causes organ toxicities and activates tolerogenic/proangiogenic STAT3 signaling. …
View article: Thrombopoietin mimetic therapy alleviates radiation-induced bone marrow vascular injury in a bone marrow transplant mouse model
Thrombopoietin mimetic therapy alleviates radiation-induced bone marrow vascular injury in a bone marrow transplant mouse model Open
Background There is a need for therapies that can mitigate bone marrow dysfunction and organ toxicity that occur following myeloablative injury and reduced intensity conditioning regimens used in patients undergoing bone marrow transplanta…
View article: Data from ImmunoPET, [<sup>64</sup>Cu]Cu-DOTA-Anti-CD33 PET-CT, Imaging of an AML Xenograft Model
Data from ImmunoPET, [<sup>64</sup>Cu]Cu-DOTA-Anti-CD33 PET-CT, Imaging of an AML Xenograft Model Open
Purpose:Acute myeloid leukemia (AML) is a highly aggressive form of leukemia, which results in poor survival outcomes. Currently, diagnosis and prognosis are based on invasive single-point bone marrow biopsies (iliac crest). There is curre…
View article: Methods and figures from ImmunoPET, [<sup>64</sup>Cu]Cu-DOTA-Anti-CD33 PET-CT, Imaging of an AML Xenograft Model
Methods and figures from ImmunoPET, [<sup>64</sup>Cu]Cu-DOTA-Anti-CD33 PET-CT, Imaging of an AML Xenograft Model Open
Supplementary methods and figures
View article: Methods and figures from ImmunoPET, [<sup>64</sup>Cu]Cu-DOTA-Anti-CD33 PET-CT, Imaging of an AML Xenograft Model
Methods and figures from ImmunoPET, [<sup>64</sup>Cu]Cu-DOTA-Anti-CD33 PET-CT, Imaging of an AML Xenograft Model Open
Supplementary methods and figures
View article: Data from ImmunoPET, [<sup>64</sup>Cu]Cu-DOTA-Anti-CD33 PET-CT, Imaging of an AML Xenograft Model
Data from ImmunoPET, [<sup>64</sup>Cu]Cu-DOTA-Anti-CD33 PET-CT, Imaging of an AML Xenograft Model Open
Purpose:Acute myeloid leukemia (AML) is a highly aggressive form of leukemia, which results in poor survival outcomes. Currently, diagnosis and prognosis are based on invasive single-point bone marrow biopsies (iliac crest). There is curre…
View article: Development of a theranostic preclinical fluorescence molecular tomography/cone beam CT-guided irradiator platform
Development of a theranostic preclinical fluorescence molecular tomography/cone beam CT-guided irradiator platform Open
Image-guided small animal radiation research platforms allow more precise radiation treatment. Commercially available small animal X-ray irradiators are often equipped with a CT/cone-beam CT (CBCT) component for target guidance. Besides ha…
View article: Development and characterization of a preclinical total marrow irradiation conditioning-based bone marrow transplant model for sickle cell disease
Development and characterization of a preclinical total marrow irradiation conditioning-based bone marrow transplant model for sickle cell disease Open
Sickle cell disease (SCD) is a serious global health problem, and currently, the only curative option is hematopoietic stem cell transplant (HCT). However, myeloablative total body irradiation (TBI)-based HCT is associated with high mortal…
View article: Treatment planning of total marrow irradiation with intensity-modulated spot-scanning proton therapy
Treatment planning of total marrow irradiation with intensity-modulated spot-scanning proton therapy Open
Purpose The goal of this study is to investigate treatment planning of total marrow irradiation (TMI) using intensity-modulated spot-scanning proton therapy (IMPT). The dosimetric parameters of the intensity-modulated proton plans were eva…
View article: Feasibility of a Novel Sparse Orthogonal Collimator–Based Preclinical Total Marrow Irradiation for Enhanced Dosimetric Conformality
Feasibility of a Novel Sparse Orthogonal Collimator–Based Preclinical Total Marrow Irradiation for Enhanced Dosimetric Conformality Open
Total marrow irradiation (TMI) has significantly improved radiation conditioning for hematopoietic cell transplantation in hematologic diseases by reducing conditioning-induced toxicities and improving survival outcomes in relapsed/refract…
View article: Longitudinal Preclinical Imaging Characterizes Extracellular Drug Accumulation After Radiation Therapy in the Healthy and Leukemic Bone Marrow Vascular Microenvironment
Longitudinal Preclinical Imaging Characterizes Extracellular Drug Accumulation After Radiation Therapy in the Healthy and Leukemic Bone Marrow Vascular Microenvironment Open
View article: First Multimodal, Three-Dimensional, Image-Guided Total Marrow Irradiation Model for Preclinical Bone Marrow Transplantation Studies
First Multimodal, Three-Dimensional, Image-Guided Total Marrow Irradiation Model for Preclinical Bone Marrow Transplantation Studies Open
View article: Assessment on the Precision of Total Marrow Irradiation: From Clinical to Preclinical Implementation
Assessment on the Precision of Total Marrow Irradiation: From Clinical to Preclinical Implementation Open
University of Minnesota Ph.D. dissertation. June 2021. Major: Biophysical Sciences and Medical Physics. Advisor: Susanta Hui. 1 computer file (PDF); xiv, 97 pages.
View article: Longitudinal preclinical imaging characterization of drug delivery potential after radiotherapy in the healthy and leukemic bone marrow vascular microenvironment
Longitudinal preclinical imaging characterization of drug delivery potential after radiotherapy in the healthy and leukemic bone marrow vascular microenvironment Open
Objectives Radiotherapy improves blood perfusion and cellular chemotherapy uptake in mice with acute lymphoblastic leukemia (ALL). However, its ability to influence drug delivery and permeation through the bone marrow vasculature (BMV) is …
View article: Feasibility of Biology-guided Radiotherapy (BgRT) Targeting Fluorodeoxyglucose (FDG) Avid Liver Metastases
Feasibility of Biology-guided Radiotherapy (BgRT) Targeting Fluorodeoxyglucose (FDG) Avid Liver Metastases Open
View article: Biophysical Characterization of the Leukemic Bone Marrow Vasculature Reveals Benefits of Neo-adjuvant Low-dose Radiotherapy
Biophysical Characterization of the Leukemic Bone Marrow Vasculature Reveals Benefits of Neo-adjuvant Low-dose Radiotherapy Open
View article: Stereotactic Radiation Enhances Efficacy of CAR-T Cells in a Murine Glioma Model
Stereotactic Radiation Enhances Efficacy of CAR-T Cells in a Murine Glioma Model Open
View article: Biophysical Characterization of the Leukemic Bone Marrow Vasculature Reveals Benefits of Neoadjuvant Low-Dose Radiation Therapy
Biophysical Characterization of the Leukemic Bone Marrow Vasculature Reveals Benefits of Neoadjuvant Low-Dose Radiation Therapy Open
View article: Potent immunomodulatory effects of an anti-CEA-IL-2 immunocytokine on tumor therapy and effects of stereotactic radiation
Potent immunomodulatory effects of an anti-CEA-IL-2 immunocytokine on tumor therapy and effects of stereotactic radiation Open
While anti-CEA antibodies have no direct effect on CEA-positive tumors, they can be used to direct potent anti-tumor effects as an antibody-IL-2 fusion protein (immunocytokine, ICK), and at the same time reduce the toxicity of IL-2 as a si…
View article: Automated in Vivo Assessment of Vascular Response to Radiation Using a Hybrid Theranostic X-Ray Irradiator/Fluorescence Molecular Imaging System
Automated in Vivo Assessment of Vascular Response to Radiation Using a Hybrid Theranostic X-Ray Irradiator/Fluorescence Molecular Imaging System Open
Hypofractionated stereotactic body radiotherapy treatments (SBRT) have demonstrated impressive results for the treatment of a variety of solid tumors. The role of tumor supporting vasculature damage in treatment outcome for SBRT has been i…
View article: ImmunoPET, [64Cu]Cu-DOTA-Anti-CD33 PET-CT, Imaging of an AML Xenograft Model
ImmunoPET, [64Cu]Cu-DOTA-Anti-CD33 PET-CT, Imaging of an AML Xenograft Model Open
Purpose: Acute myeloid leukemia (AML) is a highly aggressive form of leukemia, which results in poor survival outcomes. Currently, diagnosis and prognosis are based on invasive single-point bone marrow biopsies (iliac crest). There is curr…
View article: Multi-institutional evaluation of MVCT guided patient registration and dosimetric precision in total marrow irradiation: A global health initiative by the international consortium of total marrow irradiation
Multi-institutional evaluation of MVCT guided patient registration and dosimetric precision in total marrow irradiation: A global health initiative by the international consortium of total marrow irradiation Open
View article: AML ImmunoPET:<sup>64</sup>Cu-DOTA-anti-CD33 PET-CT imaging of AML in Xenograft mouse model
AML ImmunoPET:<sup>64</sup>Cu-DOTA-anti-CD33 PET-CT imaging of AML in Xenograft mouse model Open
Purpose Acute myeloid leukemia (AML) is a highly aggressive form of leukemia that results in poor survival outcomes. Currently, diagnosis and prognosis are based on invasive single-point bone marrow biopsies (iliac crest). There is current…
View article: Prototype Small-Animal PET-CT Imaging System for Image-Guided Radiation Therapy
Prototype Small-Animal PET-CT Imaging System for Image-Guided Radiation Therapy Open
Molecular imaging is becoming essential for precision targeted radiation therapy, yet progress is hindered from a lack of integrated imaging and treatment systems. We report the development of a prototype positron emission tomography (PET)…
View article: SMC1A is associated with radioresistance in prostate cancer and acts by regulating epithelial‐mesenchymal transition and cancer stem‐like properties
SMC1A is associated with radioresistance in prostate cancer and acts by regulating epithelial‐mesenchymal transition and cancer stem‐like properties Open
Prostate cancer is one of the most commonly diagnosed cancers and a pressing health challenge in men worldwide. Radiation therapy (RT) is widely considered a standard therapy for advanced as well as localized prostate cancer. Although this…
View article: Dose Escalation of Total Marrow Irradiation in High-Risk Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation
Dose Escalation of Total Marrow Irradiation in High-Risk Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation Open