Darryl Sampey
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View article: Attenuating nicotine’s effects with high affinity human anti-nicotine monoclonal antibodies
Attenuating nicotine’s effects with high affinity human anti-nicotine monoclonal antibodies Open
Use of nicotine-specific monoclonal antibodies (mAbs) to sequester and reduce nicotine distribution to brain has been proposed as a therapeutic approach to treat nicotine addiction (the basis of tobacco use disorder). A series of monoclona…
View article: Lipid Nanoparticle Formulation Increases Efficiency of DNA-Vectored Vaccines/Immunoprophylaxis in Animals Including Transchromosomic Bovines
Lipid Nanoparticle Formulation Increases Efficiency of DNA-Vectored Vaccines/Immunoprophylaxis in Animals Including Transchromosomic Bovines Open
The use of nucleic acid as a drug substance for vaccines and other gene-based medicines continues to evolve. Here, we have used a technology originally developed for mRNA in vivo delivery to enhance the immunogenicity of DNA vaccines. We d…
View article: Development of an antibody cocktail for treatment of Sudan virus infection
Development of an antibody cocktail for treatment of Sudan virus infection Open
Significance Ebolaviruses pose a significant threat to the global community, particularly in areas of equatorial and West Africa. While Ebola virus has caused the greatest number of human cases, Sudan virus is responsible for numerous outb…
View article: Intranasal monkeypox marmoset model: Prophylactic antibody treatment provides benefit against severe monkeypox virus disease
Intranasal monkeypox marmoset model: Prophylactic antibody treatment provides benefit against severe monkeypox virus disease Open
Concerns regarding outbreaks of human monkeypox or the potential reintroduction of smallpox into an immunological naïve population have prompted the development of animal models and countermeasures. Here we present a marmoset model of monk…
View article: Replication Study: Melanoma genome sequencing reveals frequent PREX2 mutations
Replication Study: Melanoma genome sequencing reveals frequent PREX2 mutations Open
In 2015, as part of the Reproducibility Project: Cancer Biology, we published a Registered Report (Chroscinski et al., 2014) that described how we intended to replicate selected experiments from the paper "Melanoma genome sequencing reveal…
View article: Development, characterization and optimization of a novel mammalian protein expression system
Development, characterization and optimization of a novel mammalian protein expression system Open
Biopharmaceutical manufacturing plays a critical role in global healthcare systems. Methods and techniques for protein expression in upstream bioprocesses can have the highest impact on product quality and safety and, ultimately, on delive…
View article: Sequencing of endogenous PREX2 in NRAS-G12D melanocytes
Sequencing of endogenous PREX2 in NRAS-G12D melanocytes Open
Sanger sequencing of PREX2 cDNA from NRASG12D melanocytes
View article: Registered report: Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells
Registered report: Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells Open
The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replications of 50 papers in the field of cancer biology published between 2010 and 2012. This Registe…