Darshan N. Kasal
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View article: The ID93 + GLA-3M-052-LS vaccine candidate elicits mucosal and systemic immunogenicity and protective efficacy against <i>Mycobacterium tuberculosis</i> challenge in BCG-primed Collaborative Cross inbred mice
The ID93 + GLA-3M-052-LS vaccine candidate elicits mucosal and systemic immunogenicity and protective efficacy against <i>Mycobacterium tuberculosis</i> challenge in BCG-primed Collaborative Cross inbred mice Open
New vaccine approaches are needed against tuberculosis (TB). We sought to optimize mucosal immunogenicity and protective efficacy by modulating the adjuvant component and route of immunization of a next-generation TB vaccine using the reco…
View article: An intranasally- and intramuscularly-deliverable nanostructured lipid carrier-replicon RNA vaccine drives protective systemic and mucosal immunity
An intranasally- and intramuscularly-deliverable nanostructured lipid carrier-replicon RNA vaccine drives protective systemic and mucosal immunity Open
A nucleic acid vaccine platform that could be flexibly administered either intranasally or intramuscularly could be a valuable new tool for epidemic and pandemic response, combining rapid antigen adaptability with optimal induction of syst…
View article: A bivalent self-amplifying RNA vaccine against yellow fever and Zika viruses
A bivalent self-amplifying RNA vaccine against yellow fever and Zika viruses Open
Introduction Yellow fever (YFV) and Zika (ZIKV) viruses cause significant morbidity and mortality, despite the existence of an approved YFV vaccine and the development of multiple ZIKV vaccine candidates to date. New technologies may impro…
View article: A Spray Dried Replicon Vaccine Platform for Pandemic Response
A Spray Dried Replicon Vaccine Platform for Pandemic Response Open
The recent COVID-19 pandemic, as well as the threat of a global pandemic caused by H5N1 avian influenza virus, has highlighted the need for the development of thermostable vaccines that can be manufactured and distributed rapidly to combat…
View article: Development of an Intranasally- and Intramuscularly-Administrable Replicon Vaccine Efficacious Against H5N1 Influenza Virus
Development of an Intranasally- and Intramuscularly-Administrable Replicon Vaccine Efficacious Against H5N1 Influenza Virus Open
The risk of a respiratory viral pandemic is significant, including from the now widespread panzootic H5N1 influenza virus, highlighting the need for effective, stable, and inexpensive vaccine technologies that elicit strongly protective im…
View article: An intranasal, NLC-delivered self-amplifying RNA vaccine establishes protective immunity against pre-pandemic H5N1 and H7N9 influenza
An intranasal, NLC-delivered self-amplifying RNA vaccine establishes protective immunity against pre-pandemic H5N1 and H7N9 influenza Open
Seasonal and pandemic influenzas are continuous threats to human health, requiring rapid development of vaccines to multiple evolving viral strains. New RNA vaccine technologies have the adaptability and manufacturability to facilitate pan…
View article: Systemic Immune Modulation by Gastrointestinal Nematodes
Systemic Immune Modulation by Gastrointestinal Nematodes Open
Gastrointestinal nematode (GIN) infection has applied significant evolutionary pressure to the mammalian immune system and remains a global economic and human health burden. Upon infection, type 2 immune sentinels activate a common antihel…
View article: Tuft cell-derived acetylcholine regulates epithelial fluid secretion
Tuft cell-derived acetylcholine regulates epithelial fluid secretion Open
Tuft cells are solitary chemosensory epithelial cells that can sense lumenal stimuli at mucosal barriers and secrete effector molecules to regulate the physiology and immune state of their surrounding tissue. In the small intestine, tuft c…
View article: Intranasal self-amplifying RNA SARS-CoV-2 vaccine produces protective respiratory and systemic immunity and prevents viral transmission
Intranasal self-amplifying RNA SARS-CoV-2 vaccine produces protective respiratory and systemic immunity and prevents viral transmission Open
While mRNA vaccines have been effective in combating SARS-CoV-2, waning of vaccine-induced antibody responses and lack of vaccine-induced respiratory tract immunity contribute to ongoing infection and transmission. In this work, we compare…
View article: Dendritic cells can prime anti-tumor CD8+ T cell responses through major histocompatibility complex cross-dressing
Dendritic cells can prime anti-tumor CD8+ T cell responses through major histocompatibility complex cross-dressing Open
View article: Dendritic cells can prime anti-tumor CD8+ T cell responses through major histocompatibility complex cross-dressing
Dendritic cells can prime anti-tumor CD8+ T cell responses through major histocompatibility complex cross-dressing Open
View article: A <i>Gata3</i> enhancer necessary for ILC2 development and function
A <i>Gata3</i> enhancer necessary for ILC2 development and function Open
Significance Group 2 innate lymphoid cells (ILC2s) and adaptive CD4 + T helper type 2 (Th2) cells express a common effector program orchestrated by the “master” transcription factor GATA3 that is acquired through development or differentia…
View article: Dendritic Cells Prime Anti-Tumor CD8 <sup>+</sup> T Cell Responses Through MHC-Dressing
Dendritic Cells Prime Anti-Tumor CD8 <sup>+</sup> T Cell Responses Through MHC-Dressing Open
View article: Multi-transcription factor reporter mice delineate early precursors to the ILC and LTi lineages
Multi-transcription factor reporter mice delineate early precursors to the ILC and LTi lineages Open
Transcription factor (TF) reporter mice have proved integral to the characterization of murine innate lymphoid cell (ILC) development and function. Here, we implemented a CRISPR/Cas9-generated combinatorial reporter approach for the simult…
View article: Publisher Correction: A shared Runx1-bound Zbtb16 enhancer directs innate and innate-like lymphoid lineage development
Publisher Correction: A shared Runx1-bound Zbtb16 enhancer directs innate and innate-like lymphoid lineage development Open
View article: A shared Runx1-bound Zbtb16 enhancer directs innate and innate-like lymphoid lineage development
A shared Runx1-bound Zbtb16 enhancer directs innate and innate-like lymphoid lineage development Open