Daru Guo
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View article: Identifying critical modules and biomarkers of intervertebral disc degeneration by using weighted gene co‐expression network
Identifying critical modules and biomarkers of intervertebral disc degeneration by using weighted gene co‐expression network Open
Background Intervertebral disc degeneration (IVDD) is an age‐related orthopedic degenerative disease characterized by recurrent episodes of lower back pain, the pathogenesis of which is not fully understood. This study aimed to identify ke…
View article: Integrated metagenomic and metabonomic mechanisms for the therapeutic effects of Duhuo Jisheng decoction on intervertebral disc degeneration
Integrated metagenomic and metabonomic mechanisms for the therapeutic effects of Duhuo Jisheng decoction on intervertebral disc degeneration Open
Intervertebral disc degeneration (IVDD) is a prevalent orthopedic condition with lower back pain as the predominant clinical presentation that challenges clinical treatment with few therapeutic options. Duhuo Jisheng Decoction (DHJSD) has …
View article: The bone nonunion microenvironment: A place where osteogenesis struggles with osteoclastic capacity
The bone nonunion microenvironment: A place where osteogenesis struggles with osteoclastic capacity Open
Bone nonunion is a common and serious orthopedic disorder, the occurrence of which is associated with a disruption of the dynamic balance between osteoblasts and osteoclasts during bone repair. However, the critical molecular mechanisms af…
View article: The significance of MAPK signaling pathway in the diagnosis and subtype classification of intervertebral disc degeneration
The significance of MAPK signaling pathway in the diagnosis and subtype classification of intervertebral disc degeneration Open
Intervertebral disc degeneration (IDD) is a human aging disease related mainly to inflammation, cellular senescence, RNA/DNA methylation, and ECM. The mitogen-activated protein kinase (MAPK) signaling pathway is engaged in multiple biologi…
View article: Unraveling the pivotal role of cellular senescence genes in intervertebral disc degeneration: insights from bioinformatics analysis and experimental validation
Unraveling the pivotal role of cellular senescence genes in intervertebral disc degeneration: insights from bioinformatics analysis and experimental validation Open
Intervertebral disc degeneration (IVDD) is a complex age-related physiological change involving mainly cellular senescence (CS), inflammation, impaired tissue biomechanical function, and degradation of the extracellular matrix, and is a ma…
View article: Resveratrol Promotes Proliferation and Differentiation of Pre-osteoblast MC3T3-E1 cells by Preventing Apoptosis
Resveratrol Promotes Proliferation and Differentiation of Pre-osteoblast MC3T3-E1 cells by Preventing Apoptosis Open
The purpose of this study was to investigate the mechanism by which resveratrol (Res) inhibits apoptosis and promotes proliferation and differentiation of pre-osteoblastic MC3T3-E1 cells, laying the groundwork for the treatment of osteopor…
View article: Mechanisms of inhibition of nucleus pulposus cells pyroptosis through SDF1/CXCR4-NFkB-NLRP3 axis in the treatment of intervertebral disc degeneration by Duhuo Jisheng Decoction
Mechanisms of inhibition of nucleus pulposus cells pyroptosis through SDF1/CXCR4-NFkB-NLRP3 axis in the treatment of intervertebral disc degeneration by Duhuo Jisheng Decoction Open
Intervertebral disc degeneration (IVDD) is one of the leading causes of lower back pain and the most common health problem in the world. Inflammasomes, which is mainly caused by NLRP3, mediated nucleus pulposus pyroptosis has been discover…
View article: Programmed release of hydrogel microspheres via regulating the immune microenvironment to promotes bone repair
Programmed release of hydrogel microspheres via regulating the immune microenvironment to promotes bone repair Open
Bone tissue repair is influenced by the synergistic interaction between acute immune microenvironment and osteogenesis. In this study will be independently by film dispersion method and static loading shell polymers and resveratrol liposom…
View article: Resveratrol Prevents Apoptosis, allowing Preosteoblastic MC3T3-E1 cells to Proliferate and Differentiate
Resveratrol Prevents Apoptosis, allowing Preosteoblastic MC3T3-E1 cells to Proliferate and Differentiate Open
The purpose of this study was to investigate the mechanism by which resveratrol (Res) inhibits apoptosis and promotes proliferation and differentiation of preosteoblastic MC3T3-E1, laying the groundwork for the treatment of osteoporosis (O…
View article: An in‐depth analysis of the immunomodulatory mechanisms of intervertebral disc degeneration
An in‐depth analysis of the immunomodulatory mechanisms of intervertebral disc degeneration Open
Intervertebral disc degeneration (IVDD) is the pathological basis of disc herniation, spinal stenosis, and other related diseases, and the lower back pain it produces lays a heavy financial burden on individuals and society. Thus, it is es…
View article: The significance of cellular senescence hub genes in the diagnosis and subtype classification of a comprehensive database of gene expression in intervertebral disc degeneration
The significance of cellular senescence hub genes in the diagnosis and subtype classification of a comprehensive database of gene expression in intervertebral disc degeneration Open
Intervertebral disc degeneration (IVDD) is a complex age-related physiological change involving mainly cellular senescence (CS), inflammation, impaired tissue biomechanical function, and degradation of the extracellular matrix, and is a ma…
View article: Shared mechanisms and crosstalk of COVID-19 and osteoporosis via vitamin D
Shared mechanisms and crosstalk of COVID-19 and osteoporosis via vitamin D Open
Recently accumulated evidence implicates a close association of vitamin D (VitD) insufficiency to the incidence and clinical manifestations of the COVID-19 caused by severe acute respiratory syndrome coronavirus-2 (SARS-COV-2). Populations…
View article: COVID-19 and Osteoporosis: Shared Mechanisms and Crosstalk via Vitamin D
COVID-19 and Osteoporosis: Shared Mechanisms and Crosstalk via Vitamin D Open
Recently accumulated evidence implicates a close association of vitamin D (VitD) insufficiency to the incidence and clinical manifestations of the COVID-19 caused by severe acute respiratory syndrome coronavirus-2 (SARS-COV-2). Populations…