Explanipedia

Freezing of Gait in Parkinson's Disease: Don't Leave Patients in the Dark! Open

Franky Goossens, Gijs Vissers, Bastiaan R. Bloem, Sirwan K.L. Darweesh, Jorik Nonnekes · 2025

Heart Rate Profiles During Exercise and Incident Parkinson's Disease Open

Stefan van Duijvenboden, Julia Ramírez, Job Scheurink, Sirwan K.L. Darweesh, Michele Orini , et al. · 2025

Objective To determine whether established heart rate parameters of exercise, related to cardiac autonomic function, are associated with incident Parkinson's disease, independent of both clinical and autonomic prodromal features. Methods A…

Effects of specialised physiotherapy on mortality in Parkinson’s disease: a prospective observational study Open

Jan H. L. Ypinga, Lieke H.H.M. Boonen, Marten Munneke, Patrick Jeurissen, Yoav Ben‐Shlomo , et al. · 2025

The impact of REM-sleep behavior disorder on people with Parkinson’s disease and their partners Open

Eva M. Prins, Angelique Pijpers, Nienke E. Verbeek, Sirwan K.L. Darweesh, Angelika D. Geerlings , et al. · 2025

REM-sleep behavior disorder (RBD) may affect health-related quality of life (HRQoL) of people with Parkinson's disease (PwP) and partners. We aimed to determine how RBD affects HRQoL using a mixed-methods approach. Quantitatively, we analy…

Prevalence of experienced changes in artistic and everyday creativity in people with Parkinson’s disease Open

Blanca T. M. Spee, Julia Crone, Sirwan K.L. Darweesh, Marjan J. Meinders, József Arató , et al. · 2025

Creativity is the ability to generate novel and meaningful ideas or behaviors, encompassing both artistic originality and personal satisfaction. Emerging evidence suggests that people with Parkinson’s disease (PD) may experience changes in…

Dyspnea and dystussia in Parkinson’s disease: patient-reported prevalence and determinants Open

Veerle A. van de Wetering‐van Dongen, Maarten J. Nijkrake, Philip J. van der Wees, Joanna IntHout, Sirwan K.L. Darweesh , et al. · 2025

Detection of human cytomegalovirus and evaluation of physiological parameters among patients with type 2 diabetic Open

Sirwan K.L. Darweesh, Mohammed Jasim Mohammed Shallal, Dheyaa Kadhim Al-Waeli · 2025

Background. Prolonged human cytomegalovirus (HCMV) infection leads to a pro-inflammatory environment, promoting chronic inflammatory disorders. Inflammation is a key factor in the development of diabetes and its complications. Aim. This st…

Unleashing creativity in people with Parkinson’s disease: a pilot study of a co-designed creative arts therapy Open

Blanca T. M. Spee, Nienke M. de Vries, Sara Zeggio, Marjoke Plijnaer, Jur Koksma , et al. · 2025

Background Conventional medical management, while essential, cannot address all multifaceted consequences of Parkinson’s disease (PD). This pilot study explores the potential of a co-designed creative arts therapy on health-related quality…

Promoting Physical Activity in People With Parkinson’s Disease Through a Smartphone App: A Pilot Study Open

Sabine Schootemeijer, Nienke M. de Vries, Sirwan K.L. Darweesh, Alberto Ascherio, Michael A. Schwarzschild , et al. · 2025

Background and Purpose: Physical activity has beneficial symptomatic effects for people with Parkinson’s disease (PD), but increasing—and sustaining—a physically active lifestyle remains challenging. We investigated the feasibility (abilit…

Lessons learned for pandemic preparedness in the neurodegenerative research and clinical fields: an advice report based on Parkinson’s disease as an example Open

Marije J. Splinter, Emily J. Henderson, Yoav Ben‐Shlomo, Sirwan K.L. Darweesh, Paweł Sowa , et al. · 2024

Background A sustainable pandemic preparedness strategy is essential to ensure equitable access to healthcare for individuals with neurodegenerative diseases. Moreover, it is vital to provide clinicians and researchers in the neurodegenera…

A pandemic preparedness plan for common neurodegenerative diseases: a JPND advice report Open

Marije J. Splinter, Emily J. Henderson, Yoav Ben‐Shlomo, Frank J. Wolters, Sirwan K.L. Darweesh , et al. · 2024

Background The expected seasonal recurrence of (new variants of) COVID‐19 and the emergence of other airborne infectious diseases underscore the need for a sustainable healthcare preparedness strategy. It is particularly essential to ensur…

Environmental Risk Factors for Parkinson's Disease: A Critical Review and Policy Implications Open

Kajsa Brolin, Eva Schaeffer, Ashvin Kuri, Isabell Katharina Rumrich, Artur Francisco Schumacher Schuh , et al. · 2024

The age‐standardized prevalence of Parkinson's disease (PD) has increased substantially over the years and is expected to increase further. This emphasizes the need to identify modifiable risk factors of PD, which could form a logical entr…

Exploring the Impact of Parkinson's Disease on Driving: A Population‐Based Survey Open

Marjan J. Meinders, Bart R. Maas, Bastiaan R. Bloem, Hans van Geluk, Sirwan K.L. Darweesh · 2024

Background Persons with Parkinson's disease (PD) experience progressive motor and non‐motor symptoms which may influence their ability to drive a car. This is experienced as a massive challenge by many affected individuals, for whom being …

Gut Microbial Metabolites and Future Risk of Parkinson's Disease: A Metabolome‐Wide Association Study Open

Yujia Zhao, Yunjia Lai, Sirwan K.L. Darweesh, Bastiaan R. Bloem, Lars Forsgren , et al. · 2024

Background Alterations in gut microbiota are observed in Parkinson's disease (PD). Previous studies on microbiota‐derived metabolites in PD were small‐scale and post‐diagnosis, raising concerns about reverse causality. Objectives Our goal …

Cardiac autonomic function during exercise and incident Parkinson’s disease Open

Stefan van Duijvenboden, Julia Ramírez, Job Scheurink, Sirwan K.L. Darweesh, Michele Orini , et al. · 2024

Objective To determine whether established parameters of cardiac autonomic function are associated with incident Parkinson’s disease, independent of clinical characteristics, and established autonomic prodromal features. Methods Population…

A multidimensional gender analysis of health technology self-efficacy among people with Parkinson’s disease Open

Irene Göttgens, Sirwan K.L. Darweesh, Bastiaan R. Bloem, Sabine Oertelt‐Prigione · 2024

Background Digital health technologies (DHT) enable self-tracking of bio-behavioral states and pharmacotherapy outcomes in various diseases. However, the role of gender, encompassing social roles, expectations, and relations, is often over…

The PRIME-NL study: evaluating a complex healthcare intervention for people with Parkinson’s disease in a dynamic environment Open

Bart R. Maas, Robin van den Bergh, Sanne W. van den Berg, Eveline Hulstein, Niek Stadhouders , et al. · 2024

Effect of Early Levodopa Treatment on Mortality in People with Parkinson's Disease Open

Amir H. Talebi, Sirwan K.L. Darweesh, Bas R. Bloem, Ioan Gabriel Bucur, Tom Heskes · 2024

Background The ideal timing for initiating levodopa in newly diagnosed people with Parkinson's disease (PD) is uncertain due to limited data on the long‐term effects of levodopa. Objective The aim was to investigate whether early levodopa …

Patient Experience and Feasibility of a Remote Monitoring System in Parkinson's Disease Open

Bart R. Maas, Henricus Berend Speelberg, G. de Vries, Giulio Valenti, Andreas Ejupi , et al. · 2024

Background Remote monitoring systems have the potential to measure symptoms and treatment effects in people with Parkinson's disease (PwP) in the home environment. However, information about user experience and long‐term compliance of such…

Specialized Allied Health Care for Parkinson’s Disease: State of the Art and Future Directions Open

Ingrid H.W.M. Sturkenboom, Amir H. Talebi, Bart R. Maas, Nienke M. de Vries, Sirwan K.L. Darweesh , et al. · 2024

People with Parkinson’s disease (PD) experience a range of progressive motor and non-motor symptoms, that negatively affect their daily functioning, social participation and quality of life. Allied health therapies have emerged as an effec…

Considerations on How to Prevent Parkinson’s Disease Through Exercise Open

Thomas H. Oosterhof, Sirwan K.L. Darweesh, Bastiaan R. Bloem, Nienke M. de Vries · 2024

The increasing prevalence of people with Parkinson’s disease (PD) necessitates a high priority for finding interventions to delay or even prevent the onset of PD. There is converging evidence that exercise may exert disease-modifying effec…

Digital biomarkers for non-motor symptoms in Parkinson’s disease: the state of the art Open

Jules M. Janssen Daalen, Robin van den Bergh, Eva M. Prins, Mahshid Sadat Chenarani Moghadam, Rudie van den Heuvel , et al. · 2024

Digital biomarkers that remotely monitor symptoms have the potential to revolutionize outcome assessments in future disease-modifying trials in Parkinson’s disease (PD), by allowing objective and recurrent measurement of symptoms and signs…

Natural Health Products for Symptomatic Relief of Parkinson’s Disease: Prevalence, Interest, and Awareness Open

Sandra Diadhiou, Bart R. Maas, Sabine Schootemeijer, Bastiaan R. Bloem, Nienke M. de Vries , et al. · 2024

Background: Natural health products have emerged as a potential symptomatic therapeutic approach for people with Parkinson’s disease (PD). Objective: To determine the prevalence of natural health product use, interest in natural health pro…

Guide to Decomposition of Causal Effects Into Mediation, Interaction, and Direct Effects Open

Nina A. Hilkens, Gemma Hammerton, Nienke M. de Vries, Bastiaan R. Bloem, Yoav Ben‐Shlomo , et al. · 2024

Mediation analysis can be applied in medical research with the aim of understanding the pathways that operate between an exposure and its effects on an outcome. This method can help to improve our understanding of pathophysiologic mechanis…

Assessing the validity of a Parkinson’s care evaluation: the PRIME-NL study Open

Liza M. Y. Gelissen, Robin van den Bergh, Amir H. Talebi, Angelika D. Geerlings, Bart R. Maas , et al. · 2024

How Lifetime Evolution of Parkinson’s Disease Could Shape Clinical Trial Design: A Shared Patient–Clinician Viewpoint Open

Jules M. Janssen Daalen, Aranka Gerritsen, Gijs Gerritse, Jan Gouman, Hannie Meijerink , et al. · 2024

Parkinson’s disease (PD) has a long, heterogeneous, pre-diagnostic phase, during which pathology insidiously accumulates. Increasing evidence suggests that environmental and lifestyle factors in early life contribute to disease risk and pr…

The PRIME-NL study: evaluating a complex healthcare intervention for people with Parkinson’s disease in a dynamic environment Open

Bart R. Maas, Robin van den Bergh, Sanne W. van den Berg, Eveline Hulstein, Niek Stadhouders , et al. · 2024

Background An innovative, integrative care model for people with Parkinson (PRIME Parkinson) has gradually been implemented in a selected region of the Netherlands since 2021. A prospective evaluation of this model (PRIME-NL study) was ini…

Age and gender differences in non-motor symptoms in people with Parkinson’s disease Open

Bart R. Maas, Irene Göttgens, Hermina P. S. Tijsse Klasen, Willanka Kapelle, Danique L. M. Radder , et al. · 2024

Background Non-motor symptoms of Parkinson’s disease (PD) are highly prevalent and heterogenic. Previous studies aimed to gain more insight on this heterogeneity by investigating age and gender differences in non-motor symptom severity, bu…

Non-Linear Temporal Evolution of Microstructural Integrity in Cerebellar Peduncles and Their Dopaminergic Correlates in Parkinson's Disease: A Cross-Sectional and Longitudinal Cohort Study Open

Chentao He, Rui Yang, Siming Rong, Piao Zhang, Xi Chen , et al. · 2024

The epidemiology of Parkinson's disease Open

Yoav Ben‐Shlomo, Sirwan K.L. Darweesh, Jorge J. Llibre‐Guerra, Connie Marras, Marta San Luciano , et al. · 2024

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