Daryl Boey
YOU?
Author Swipe
View article: Single-cell omics-based characterization of human basophils reveals two transcriptionally distinct populations
Single-cell omics-based characterization of human basophils reveals two transcriptionally distinct populations Open
Background Basophils are implicated in various diseases including allergies, but a comprehensive characterization of human basophils has yet to be performed at the single-cell level. Objective We aimed to generate a single-cell omics-based…
View article: Single-cell perspectives on mast cells in health and systemic mastocytosis
Single-cell perspectives on mast cells in health and systemic mastocytosis Open
Mast cells play a critical role in the human immune system and in adults originate from the bone marrow through hematopoiesis. Mast cells are known to contribute to allergic diseases, and deregulation of mast cell development leads to mast…
View article: Single-cell perspectives on mast cells in health and systemic mastocytosis
Single-cell perspectives on mast cells in health and systemic mastocytosis Open
Mast cells play a critical role in the human immune system and in adults originate from the bone marrow through hematopoiesis. Mast cells are known to contribute to allergic diseases, and deregulation of mast cell development leads to mast…
View article: No indication of aberrant neutrophil extracellular trap release in indolent or advanced systemic mastocytosis
No indication of aberrant neutrophil extracellular trap release in indolent or advanced systemic mastocytosis Open
In disease states with chronic inflammation, there is a crosstalk between mast cells and neutrophil granulocytes in the inflamed microenvironment, which may be potentiated by tryptase. In systemic mastocytosis (SM), mast cells are constitu…
View article: A single-cell map of vascular and tissue lymphocytes identifies proliferative TCF-1+ human innate lymphoid cells
A single-cell map of vascular and tissue lymphocytes identifies proliferative TCF-1+ human innate lymphoid cells Open
Innate lymphoid cells (ILCs) play important roles in tissue homeostasis and host defense, but the proliferative properties and migratory behavior of especially human ILCs remain poorly understood. Here we mapped at single-cell resolution t…
View article: Single-cell transcriptomics reveals the identity and regulators of human mast cell progenitors
Single-cell transcriptomics reveals the identity and regulators of human mast cell progenitors Open
Mast cell accumulation is a hallmark of a number of diseases, including allergic asthma and systemic mastocytosis. Immunoglobulin E–mediated crosslinking of the FcεRI receptors causes mast cell activation and contributes to disease pathoge…
View article: Immunoprofiling Reveals Novel Mast Cell Receptors and the Continuous Nature of Human Lung Mast Cell Heterogeneity
Immunoprofiling Reveals Novel Mast Cell Receptors and the Continuous Nature of Human Lung Mast Cell Heterogeneity Open
Background Immunohistochemical analysis of granule-associated proteases has revealed that human lung mast cells constitute a heterogeneous population of cells, with distinct subpopulations identified. However, a systematic and comprehensiv…
View article: Single-cell transcriptomics reveals the identity and regulators of human mast cell progenitors
Single-cell transcriptomics reveals the identity and regulators of human mast cell progenitors Open
Mast cell accumulation is a hallmark of a number of diseases including allergic asthma and systemic mastocytosis. IgE-mediated crosslinking of the FcεRI receptors causes mast cell activation and contributes to disease pathogenesis. The mas…