The insights gained will contribute to developing strategic frameworks and consensus guidelines that can effectively guide clinicians in optimizing outcomes for myeloma patients in diverse healthcare settings.

Multiple myeloma (MM) is the second most common haematologic malignancy and remains incurable. Significant advances have been made in both supportive care and definitive therapy for MM, leading to marked improvements in survival and quality of life. The availability of potent novel agent-based induction regimens, as well as methods to assess deeper levels of response, has transformed the landscape of MM therapy. Balancing therapeutic efficacy against toxicities and cost-effectiveness remains a key challenge to be …

Introduction Natural killer/T cell lymphoma (NKTL) is an aggressive malignancy associated with poor prognosis. This is largely due to limited treatment options, especially for relapsed patients. Immunotherapies like immune checkpoint inhibitors (ICI) and anti-CD38 therapies have shown promising but variable clinical efficacies. Combining these therapies has been suggested to enhance efficacy. Methods We conducted a case study on a relapsed NKTL patient treated sequentially with anti-CD38 followed by ICI (anti-PD1)…

AL amyloidosis is the most common form of systemic amyloidosis. However, the non-specific nature of presenting symptoms requires the need for a heightened clinical suspicion to detect unexplained manifestations in the appropriate clinical setting. Early detection and treatment are crucial as the degree of cardiac involvement emerges as a primary prognostic predictor of survival in a patient with AL amyloidosis. Following the diagnosis of AL amyloidosis with appropriate tissue biopsies, prompt treatment with a bort…

<p>PDF file - 75K, Sequence analysis summary of tumor and blood samples from four NKTCL cases</p>