Amitava Dasgupta
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View article: Blood collection device components: issues, innovations, and recommendations for clinical laboratories and manufacturers—a narrative review
Blood collection device components: issues, innovations, and recommendations for clinical laboratories and manufacturers—a narrative review Open
View article: <i>In vitro</i> and <i>in vivo</i> synergy of Vancomycin and β-lactams against drug-resistant <i>Mycobacterium tuberculosis</i> and Non-tuberculous mycobacteria
<i>In vitro</i> and <i>in vivo</i> synergy of Vancomycin and β-lactams against drug-resistant <i>Mycobacterium tuberculosis</i> and Non-tuberculous mycobacteria Open
The unabated increase in antimicrobial resistance has underlined the importance of identifying novel drug combinations which eliminate infections more potently and likely reduce the emergence of resistance. In this context, we have identif…
View article: Synthesis of Novel Tryptanthrin Hydrazide Hydrazones for Photophysical and Biological applications
Synthesis of Novel Tryptanthrin Hydrazide Hydrazones for Photophysical and Biological applications Open
View article: Salmonella Typhimurium effector SseI regulates host peroxisomal dynamics to acquire lysosomal cholesterol
Salmonella Typhimurium effector SseI regulates host peroxisomal dynamics to acquire lysosomal cholesterol Open
View article: Very unusual extremely high ferritin with cytokine release syndrome in a patient with hematological malignancy after experimental chimeric antigen receptor (CAR)–T-Cell therapy
Very unusual extremely high ferritin with cytokine release syndrome in a patient with hematological malignancy after experimental chimeric antigen receptor (CAR)–T-Cell therapy Open
Cytokine release syndrome after experimental (CAR) T cell therapy may cause extremely elevated ferritin and hemophagocytic lymphohistiocytosis -like syndrome.
View article: Prevention of potential delayed hemolytic transfusion reaction in two sickle cell patients using intravenous immunoglobulins and steroids before and after red blood cell exchange with antigen positive units and review literature
Prevention of potential delayed hemolytic transfusion reaction in two sickle cell patients using intravenous immunoglobulins and steroids before and after red blood cell exchange with antigen positive units and review literature Open
Emergent Red Blood Cell (RBC) exchange is indicated in sickle cell disease (SCD) patients with severe acute chest syndrome. However, fully matched RBC units may not be available for patients with multiple RBC antibodies. Intravenous immuno…
View article: Polycationic phosphorous dendrimer potentiates multiple antibiotics against drug-resistant mycobacterial pathogens
Polycationic phosphorous dendrimer potentiates multiple antibiotics against drug-resistant mycobacterial pathogens Open
Mycobacterium tuberculosis (Mtb), causative agent of tuberculosis (TB) and non-tubercular mycobacterial (NTM) pathogens such as Mycobacterium abscessus are one of the most critical concerns worldwide due to increased drug-resistance result…
View article: Synthesis and biological evaluation of new naphthalimide–thiourea derivatives as potent antimicrobial agents active against multidrug-resistant <i>Staphylococcus aureus</i> and <i>Mycobacterium tuberculosis</i>
Synthesis and biological evaluation of new naphthalimide–thiourea derivatives as potent antimicrobial agents active against multidrug-resistant <i>Staphylococcus aureus</i> and <i>Mycobacterium tuberculosis</i> Open
Novel series of naphthalimide thiourea derivatives were synthesised and evaluated against bacterial pathogen panel and mycobacterial pathogen panel.
View article: Preclinical Model of Mycobacteroides Abscessus Lung Disease by Nose-Only Exposure of Mice to Bacterial Aerosol
Preclinical Model of Mycobacteroides Abscessus Lung Disease by Nose-Only Exposure of Mice to Bacterial Aerosol Open
View article: Development of naphthalimide hydrazide derivatives as potent antibacterial agents against carbapenem-resistant <i>A. baumannii</i>
Development of naphthalimide hydrazide derivatives as potent antibacterial agents against carbapenem-resistant <i>A. baumannii</i> Open
Novel naphthalimide hydrazide derivatives were synthesised and evaluated against carbapenem-resistant A. baumannii .
View article: B-303 Comparison of Tacrolimus Concentrations Obtained By the Newly Approved Alinity i Tacrolimus Assay With a Reference Liquid-Chromatography Combined With Tandem Mass spectrometry Assay
B-303 Comparison of Tacrolimus Concentrations Obtained By the Newly Approved Alinity i Tacrolimus Assay With a Reference Liquid-Chromatography Combined With Tandem Mass spectrometry Assay Open
Background Tacrolimus belongs to the calcineurin-inhibitor class of medications and used for preventing and maintenance of organ rejection in transplant recipients alone or in combination with other medications. Due to narrow therapeutic w…
View article: Mycobacterial lipid-derived immunomodulatory drug- liposome conjugate eradicates endosome-localized mycobacteria
Mycobacterial lipid-derived immunomodulatory drug- liposome conjugate eradicates endosome-localized mycobacteria Open
View article: Rare case of benign transient hyperphosphatasemia in a complicated multiorgan adult transplant patient: Case report and literature review
Rare case of benign transient hyperphosphatasemia in a complicated multiorgan adult transplant patient: Case report and literature review Open
After ruling out all possibilities that may cause elevated ALP, we concluded that this is a rare case of benign transient hyperphosphatasemia in an adult transplant recipient.
View article: Angioedema in a Patient with Underlying Lymphoproliferative Disorder
Angioedema in a Patient with Underlying Lymphoproliferative Disorder Open
A 61-year-old female presented to the emergency department for sudden tongue swelling with difficulty talking and swallowing. She received epinephrine and was admitted to the intensive care unit. Swelling resolved within a few hours after …
View article: Perioperative therapeutic plasma exchange in a patient with rare Factor XIII inhibitor
Perioperative therapeutic plasma exchange in a patient with rare Factor XIII inhibitor Open
View article: EphH, a unique epoxide hydrolase encoded by Rv3338 is involved in the survival of Mycobacterium tuberculosis under in vitro stress and vacuolar pH-induced changes
EphH, a unique epoxide hydrolase encoded by Rv3338 is involved in the survival of Mycobacterium tuberculosis under in vitro stress and vacuolar pH-induced changes Open
Introduction Mycobacterium tuberculosis (Mtb), one of the deadliest human pathogen, has evolved with different strategies of survival inside the host, leading to a chronic state of infection. Phagosomally residing Mtb encounters a variety …
View article: Synthesis and pharmacological evaluation of 1,3-diaryl substituted pyrazole based (thio)urea derivatives as potent antimicrobial agents against multi-drug resistant <i>Staphylococcus aureus</i> and <i>Mycobacterium tuberculosis</i>
Synthesis and pharmacological evaluation of 1,3-diaryl substituted pyrazole based (thio)urea derivatives as potent antimicrobial agents against multi-drug resistant <i>Staphylococcus aureus</i> and <i>Mycobacterium tuberculosis</i> Open
One lead compound, 7a, (3,4-dichlorophenyl derivative), exhibited potent activity against S. aureus (MIC = 0.25 μg mL −1 ), and the other compound, 7j (2,4-difluorophenyl derivative) against Mycobacterium tuberculosis (MIC = 1 μg mL −1 ) w…
View article: <i>In Vitro</i> and <i>In Vivo</i> Activity of Gepotidacin against Drug-Resistant Mycobacterial Infections
<i>In Vitro</i> and <i>In Vivo</i> Activity of Gepotidacin against Drug-Resistant Mycobacterial Infections Open
Mycobacterial pathogens, including nontuberculous mycobacteria (NTM) and Mycobacterium tuberculosis , are pathogens of significant worldwide interest owing to their inherent drug resistance to a wide variety of FDA-approved drugs as well a…
View article: Isoxazole carboxylic acid methyl ester-based urea and thiourea derivatives as promising antitubercular agents
Isoxazole carboxylic acid methyl ester-based urea and thiourea derivatives as promising antitubercular agents Open
View article: Mechanistic insight into the role of mevalonate kinase by a natural fatty acid-mediated killing of Leishmania donovani
Mechanistic insight into the role of mevalonate kinase by a natural fatty acid-mediated killing of Leishmania donovani Open
View article: <i>In vitro</i> and <i>in vivo</i> activity of Gepotidacin against drug-resistant mycobacterial infections
<i>In vitro</i> and <i>in vivo</i> activity of Gepotidacin against drug-resistant mycobacterial infections Open
Mycobacterial pathogens including Non-tuberculous mycobacteria (NTM) and M. tuberculosis (Mtb), are pathogens of significant worldwide interest owing to inherent drug resistance to a wide variety of FDA-approved drugs as well as causing a …
View article: CCDC 2056172: Experimental Crystal Structure Determination
CCDC 2056172: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2056171: Experimental Crystal Structure Determination
CCDC 2056171: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Mycobactin Analogues with Excellent Pharmacokinetic Profile Demonstrate Potent Antitubercular Specific Activity and Exceptional Efflux Pump Inhibition
Mycobactin Analogues with Excellent Pharmacokinetic Profile Demonstrate Potent Antitubercular Specific Activity and Exceptional Efflux Pump Inhibition Open
In this study, we have designed and synthesized pyrazoline analogues that partially mimic the structure of mycobactin, to address the requirement of novel therapeutics to tackle the emerging global challenge of antimicrobial resistance (AM…
View article: Synthesis and evaluation of triazole congeners of nitro-benzothiazinones potentially active against drug resistant <i>Mycobacterium tuberculosis</i> demonstrating bactericidal efficacy
Synthesis and evaluation of triazole congeners of nitro-benzothiazinones potentially active against drug resistant <i>Mycobacterium tuberculosis</i> demonstrating bactericidal efficacy Open
Lead compound was identified to be a selective inhibitor of Mtb H37Rv with no appreciable cytotoxicity, demonstrating quite comparable bactericidal efficacy to RIF.
View article: Oncology Patients Who Develop Transfusion-Associated Circulatory Overload: An Observational Study
Oncology Patients Who Develop Transfusion-Associated Circulatory Overload: An Observational Study Open
Background Transfusion-associated circulatory overload (TACO) is a largely preventable transfusion complication that results in significant morbidity and mortality. Cancers, related treatments, and comorbidities are among the factors that …
View article: Safe Polycationic Dendrimers as Potent Oral In Vivo Inhibitors of <i>Mycobacterium tuberculosis</i>: A New Therapy to Take Down Tuberculosis
Safe Polycationic Dendrimers as Potent Oral In Vivo Inhibitors of <i>Mycobacterium tuberculosis</i>: A New Therapy to Take Down Tuberculosis Open
The long-term treatment of tuberculosis (TB) sometimes leads to nonadherence to treatment, resulting in multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis. Inadequate bioavailability of the drug is the main factor …
View article: Characterization and preclinical efficacy of PTP-001, a novel human tissue biologic in development for the treatment of OA
Characterization and preclinical efficacy of PTP-001, a novel human tissue biologic in development for the treatment of OA Open
View article: Merits of Monitoring Free Carbamazepine Measurements with an Automated Method
Merits of Monitoring Free Carbamazepine Measurements with an Automated Method Open
View article: Copper mediated one-pot synthesis of quinazolinones and exploration of piperazine linked quinazoline derivatives as anti-mycobacterial agents
Copper mediated one-pot synthesis of quinazolinones and exploration of piperazine linked quinazoline derivatives as anti-mycobacterial agents Open
A facile method was developed for the synthesis of quinazolinone derivatives in a one-pot condensation reaction via in situ amine generation using ammonia as the amine source and with the formation of four new C–N bonds in good to excellen…