Dasharath Kondhare
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View article: α‐D Nucleoside Based Self‐Healing Supramolecular Hydrogels Derived from the α‐D Anomers of 2’‐Deoxyguanosine and Fluorescent 8‐Azapurine 2’‐Deoxyribofuranosides
α‐D Nucleoside Based Self‐Healing Supramolecular Hydrogels Derived from the α‐D Anomers of 2’‐Deoxyguanosine and Fluorescent 8‐Azapurine 2’‐Deoxyribofuranosides Open
Self‐assembly of α‐D nucleosides to supramolecular hydrogels is described in detail. Hydrogel formation is studied on α‐D 2’‐deoxyguanosine (α‐dG), and the fluorescent 8‐azapurine α‐D nucleosides 2‐amino‐8‐aza‐2’‐deoxyadenosine (α‐2‐NH 2 ‐…
View article: 7-Alkynylated and 7-Halogenated 7-Deazapurine-2,6-Diamine 2’-Deoxyribonucleosides: Crystal Structure, Hirshfeld Surface Analysis, Functionalization and Physical Properties
7-Alkynylated and 7-Halogenated 7-Deazapurine-2,6-Diamine 2’-Deoxyribonucleosides: Crystal Structure, Hirshfeld Surface Analysis, Functionalization and Physical Properties Open
View article: CCDC 2244144: Experimental Crystal Structure Determination
CCDC 2244144: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: DNA Strand Displacement with Base Pair Stabilizers: Purine‐2,6‐Diamine and 8‐Aza‐7‐Bromo‐7‐Deazapurine‐2,6‐Diamine Oligonucleotides Invade Canonical DNA and New Fluorescent Pyrene Click Sensors Monitor the Reaction
DNA Strand Displacement with Base Pair Stabilizers: Purine‐2,6‐Diamine and 8‐Aza‐7‐Bromo‐7‐Deazapurine‐2,6‐Diamine Oligonucleotides Invade Canonical DNA and New Fluorescent Pyrene Click Sensors Monitor the Reaction Open
Purine‐2,6‐diamine and 8‐aza‐7‐deaza‐7‐bromopurine‐2,6‐diamine 2’‐deoxyribonucleosides ( 1 and 2 ) were implemented in isothermal DNA strand displacement reactions. Nucleoside 1 is a weak stabilizer of dA‐dT base pairs, nucleoside 2 evokes…
View article: The 2′-deoxyribofuranoside of 3-phenyltetrahydropyrimido[4,5-<i>c</i>]pyridazin-7-one: a bicyclic nucleoside with sugar residues in <i>N</i> and <i>S</i> conformations, and its molecular recognition
The 2′-deoxyribofuranoside of 3-phenyltetrahydropyrimido[4,5-<i>c</i>]pyridazin-7-one: a bicyclic nucleoside with sugar residues in <i>N</i> and <i>S</i> conformations, and its molecular recognition Open
The title compound 3-phenyltetrahydropyrimido[4,5- c ]pyridazine 2′-deoxyribonucleoside [systematic name: 6-(2-deoxy-β-D- erythro -pentofuranosyl)-5,6,7,8-tetrahydro-3-phenylpyrimido[4,5- c ]pyridazin-7-one monohydrate, C 17 H 18 N 4 O 4 ·…
View article: Anomeric DNA Strand Displacement with α‐D Oligonucleotides as Invaders and Ethidium Bromide as Fluorescence Sensor for Duplexes with α/β‐, β/β‐ and α/α‐D Configuration
Anomeric DNA Strand Displacement with α‐D Oligonucleotides as Invaders and Ethidium Bromide as Fluorescence Sensor for Duplexes with α/β‐, β/β‐ and α/α‐D Configuration Open
DNA strand displacement is a technique to exchange one strand of a double stranded DNA by another strand (invader). It is an isothermal, enzyme free method driven by single stranded overhangs (toeholds) and is employed in DNA amplification…
View article: CCDC 2095197: Experimental Crystal Structure Determination
CCDC 2095197: Experimental Crystal Structure Determination Open
View article: 5‐Aza‐7‐deazaguanine–Isoguanine and Guanine–Isoguanine Base Pairs in Watson–Crick DNA: The Impact of Purine Tracts, Clickable Dendritic Side Chains, and Pyrene Adducts
5‐Aza‐7‐deazaguanine–Isoguanine and Guanine–Isoguanine Base Pairs in Watson–Crick DNA: The Impact of Purine Tracts, Clickable Dendritic Side Chains, and Pyrene Adducts Open
The Watson–Crick coding system depends on the molecular recognition of complementary purine and pyrimidine bases. Now, the construction of hybrid DNAs with Watson–Crick and purine–purine base pairs decorated with dendritic side chains was …
View article: The 2‐Amino Group of 8‐Aza‐7‐deaza‐7‐bromopurine‐2,6‐diamine and Purine‐2,6‐diamine as Stabilizer for the Adenine–Thymine Base Pair in Heterochiral DNA with Strands in Anomeric Configuration
The 2‐Amino Group of 8‐Aza‐7‐deaza‐7‐bromopurine‐2,6‐diamine and Purine‐2,6‐diamine as Stabilizer for the Adenine–Thymine Base Pair in Heterochiral DNA with Strands in Anomeric Configuration Open
Stabilization of DNA is beneficial for many applications in the fields of DNA therapeutics, diagnostics, and materials science. Now, this phenomenon is studied on heterochiral DNA, an autonomous DNA recognition system with complementary st…
View article: CCDC 1950946: Experimental Crystal Structure Determination
CCDC 1950946: Experimental Crystal Structure Determination Open
View article: 7-Iodo-5-aza-7-deazaguanine ribonucleoside: crystal structure, physical properties, base-pair stability and functionalization
7-Iodo-5-aza-7-deazaguanine ribonucleoside: crystal structure, physical properties, base-pair stability and functionalization Open
The positional change of nitrogen-7 of the RNA constituent guanosine to the bridgehead position-5 leads to the base-modified nucleoside 5-aza-7-deazaguanosine. Contrary to guanosine, this molecule cannot form Hoogsteen base pairs and the W…
View article: CCDC 1917214: Experimental Crystal Structure Determination
CCDC 1917214: Experimental Crystal Structure Determination Open
View article: Curcumin Analogues with Aldose Reductase Inhibitory Activity: Synthesis, Biological Evaluation, and Molecular Docking
Curcumin Analogues with Aldose Reductase Inhibitory Activity: Synthesis, Biological Evaluation, and Molecular Docking Open
Curcumin, a constituent of Curcuma longa, has shown numerous biological and pharmacological activities, including antidiabetic effects. Here, a novel series of curcumin analogues were synthesized and evaluated for in vitro inhibition of al…
View article: Phytochemical profile, aldose reductase inhibitory, and antioxidant activities of Indian traditional medicinal Coccinia grandis (L.) fruit extract
Phytochemical profile, aldose reductase inhibitory, and antioxidant activities of Indian traditional medicinal Coccinia grandis (L.) fruit extract Open