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View article: Requirements for nuclear GRP78 transcriptional regulatory activities and interaction with nuclear GRP94
Requirements for nuclear GRP78 transcriptional regulatory activities and interaction with nuclear GRP94 Open
GRP78, a molecular chaperone primarily located in the endoplasmic reticulum (ER), has recently been discovered to translocate into the nucleus of stressed and cancer cells where it assumes a new function reprogramming the transcriptome. Th…
View article: ER chaperone GRP78/BiP translocates to the nucleus under stress and acts as a transcriptional regulator
ER chaperone GRP78/BiP translocates to the nucleus under stress and acts as a transcriptional regulator Open
Cancer cells are commonly subjected to endoplasmic reticulum (ER) stress. To gain survival advantage, cancer cells exploit the adaptive aspects of the unfolded protein response such as upregulation of the ER luminal chaperone GRP78. The fi…
View article: GRP78 Inhibitor YUM70 Suppresses SARS-CoV-2 Viral Entry, Spike Protein Production and Ameliorates Lung Damage
GRP78 Inhibitor YUM70 Suppresses SARS-CoV-2 Viral Entry, Spike Protein Production and Ameliorates Lung Damage Open
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the COVID-19 pandemic, has given rise to many new variants with increased transmissibility and the ability to evade vaccine protection. The 78-kDa glu…
View article: Targeting GRP78 suppresses oncogenic KRAS protein expression and reduces viability of cancer cells bearing various KRAS mutations
Targeting GRP78 suppresses oncogenic KRAS protein expression and reduces viability of cancer cells bearing various KRAS mutations Open
KRAS is the most commonly mutated oncogene in human cancers with limited therapeutic options, thus there is a critical need to identify novel targets and inhibiting agents. The 78-kDa glucose-regulated protein GRP78, which is upregulated i…
View article: GRP78 binds SARS-CoV-2 Spike protein and ACE2 and GRP78 depleting antibody blocks viral entry and infection in vitro
GRP78 binds SARS-CoV-2 Spike protein and ACE2 and GRP78 depleting antibody blocks viral entry and infection in vitro Open
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the current COVID-19 global pandemic, utilizes the host receptor angiotensin-converting enzyme 2 (ACE2) for viral entry. However, other host factors m…
View article: Suppression of stress induction of the 78-kilodalton glucose regulated protein (GRP78) in cancer by IT-139, an anti-tumor ruthenium small molecule inhibitor
Suppression of stress induction of the 78-kilodalton glucose regulated protein (GRP78) in cancer by IT-139, an anti-tumor ruthenium small molecule inhibitor Open
In many cancers, combination therapy regimens are successfully improving response and survival rates, but the challenges of toxicity remain. GRP78, the master regulator of the unfolded protein response, is emerging as a target that is upre…
View article: Endoplasmic reticulum stress activates SRC, relocating chaperones to the cell surface where GRP78/CD109 blocks TGF-β signaling
Endoplasmic reticulum stress activates SRC, relocating chaperones to the cell surface where GRP78/CD109 blocks TGF-β signaling Open
Significance Endoplasmic reticulum (ER) stress-mediated relocalization of ER chaperones to the cell surface allows cells to expand their functionality beyond the ER, impacting survival, death, migration, and immunity. However, little is kn…
View article: New role of endoplasmic reticulum chaperones in regulating metaplasia during tumorigenesis
New role of endoplasmic reticulum chaperones in regulating metaplasia during tumorigenesis Open
Metaplasia is emerging as a key process in tumorigenesis. We discovered that 2 essential endoplasmic reticulum (ER) chaperones, 78-kilodalton glucose-regulated protein (GRP78) and 94-kilodalton glucose-regulated protein (GRP94) have a role…
View article: GRP78 haploinsufficiency suppresses acinar-to-ductal metaplasia, signaling, and mutant <i>Kras</i> -driven pancreatic tumorigenesis in mice
GRP78 haploinsufficiency suppresses acinar-to-ductal metaplasia, signaling, and mutant <i>Kras</i> -driven pancreatic tumorigenesis in mice Open
Significance KRAS is mutated in more than 90% of pancreatic adenocarcinoma (PDAC). Despite its well-known role in cancer, development of drugs directly targeting KRAS has been unfruitful, underscoring the critical need to identify novel th…