Dateng Li
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View article: A simulation study of the performance of statistical models for count outcomes with excessive zeros
A simulation study of the performance of statistical models for count outcomes with excessive zeros Open
Background : Outcome measures that are count variables with excessive zeros are common in health behaviors research. Examples include the number of standard drinks consumed or alcohol‐related problems experienced over time. There is a lack…
View article: Targeting macrophage M1 polarization suppression through PCAF inhibition alleviates autoimmune arthritis via synergistic NF-κB and H3K9Ac blockade
Targeting macrophage M1 polarization suppression through PCAF inhibition alleviates autoimmune arthritis via synergistic NF-κB and H3K9Ac blockade Open
Sustained inflammatory invasion leads to joint damage and progressive disability in several autoimmune rheumatic diseases. In recent decades, targeting M1 macrophage polarization has been suggested as a promising therapeutic strategy for a…
View article: Casirivimab + imdevimab accelerates symptom resolution linked to improved COVID-19 outcomes across susceptible antibody and risk profiles
Casirivimab + imdevimab accelerates symptom resolution linked to improved COVID-19 outcomes across susceptible antibody and risk profiles Open
Severe, protracted symptoms are associated with poor outcomes in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In a placebo-controlled study of casirivimab and imdevimab (CAS + IMD) in persons at high risk of seve…
View article: ALKBH5 facilitates CYP1B1 mRNA degradation via m6A demethylation to alleviate MSC senescence and osteoarthritis progression
ALKBH5 facilitates CYP1B1 mRNA degradation via m6A demethylation to alleviate MSC senescence and osteoarthritis progression Open
Improving health and delaying aging is the focus of medical research. Previous studies have shown that mesenchymal stem cell (MSC) senescence is closely related to organic aging and the development of aging-related diseases such as osteoar…
View article: A Simulation Study of the Performance of Statistical Models for Count Outcomes with Excessive Zeros
A Simulation Study of the Performance of Statistical Models for Count Outcomes with Excessive Zeros Open
Background: Outcome measures that are count variables with excessive zeros are common in health behaviors research. There is a lack of empirical data about the relative performance of prevailing statistical models when outcomes are zero-in…
View article: Decrotonylation of AKT1 promotes AKT1 phosphorylation and activation during myogenic differentiation
Decrotonylation of AKT1 promotes AKT1 phosphorylation and activation during myogenic differentiation Open
Introduction: Myogenic differentiation plays an important role in pathophysiological processes including muscle injury and regeneration, as well as muscle atrophy. A novel type of posttranslational modification, crotonylation, has been rep…
View article: A Machine-Learning Approach to Developing a Predictive Signature Based on Transcriptome Profiling of Ground-Glass Opacities for Accurate Classification and Exploring the Immune Microenvironment of Early-Stage LUAD
A Machine-Learning Approach to Developing a Predictive Signature Based on Transcriptome Profiling of Ground-Glass Opacities for Accurate Classification and Exploring the Immune Microenvironment of Early-Stage LUAD Open
Screening for early-stage lung cancer with low-dose computed tomography is recommended for high-risk populations; consequently, the incidence of pure ground-glass opacity (pGGO) is increasing. Ground-glass opacity (GGO) is considered the a…
View article: Oridonin Sensitizes Hepatocellular Carcinoma to the Anticancer Effect of Sorafenib by Targeting the Akt Pathway [Corrigendum]
Oridonin Sensitizes Hepatocellular Carcinoma to the Anticancer Effect of Sorafenib by Targeting the Akt Pathway [Corrigendum] Open
[This corrects the article DOI: 10.2147/CMAR.S257482.].
View article: Sample Size Calculation for Cluster Randomized Trials with Zero-inflated Count Outcomes
Sample Size Calculation for Cluster Randomized Trials with Zero-inflated Count Outcomes Open
Cluster randomized trails (CRT) have been widely employed in medical and public health research. Many clinical count outcomes, such as the number of falls in nursing homes, exhibit excessive zero values. In the presence of zero inflation, …
View article: <p>Oridonin Sensitizes Hepatocellular Carcinoma to the Anticancer Effect of Sorafenib by Targeting the Akt Pathway</p>
Oridonin Sensitizes Hepatocellular Carcinoma to the Anticancer Effect of Sorafenib by Targeting the Akt Pathway Open
Oridonin combined with sorafenib synergistically inhibited proliferation, migration, invasion, and epithelial-mesenchymal transition and induced apoptosis by targeting the Akt pathway but not NF-κB or MAPK signaling.
View article: <p>Bisdemethoxycurcumin Inhibits Hepatocellular Carcinoma Proliferation Through Akt Inactivation via CYLD-Mediated Deubiquitination</p>
Bisdemethoxycurcumin Inhibits Hepatocellular Carcinoma Proliferation Through Akt Inactivation via CYLD-Mediated Deubiquitination Open
BDMC inhibited HCC cell proliferation, and that this effect was induced by Akt inactivation via CYLD-mediated deubiquitination.
View article: Sample Size Calculation of Clinical Trials with Correlated Outcomes
Sample Size Calculation of Clinical Trials with Correlated Outcomes Open
In this thesis, we investigate sample size calculation for three kinds of clinical trials: (1). Randomized controlled trials (RCTs) with longitudinal count outcomes; (2). Cluster randomized trials (CRTs) with count outcomes; (3). CRTs with…
View article: Considering Over-dispersion in the Sample Size Calculation for Clinical Trials with Repeated Count Measurements
Considering Over-dispersion in the Sample Size Calculation for Clinical Trials with Repeated Count Measurements Open
Over-dispersed count variables are frequently encountered in biomedical research. Despite extensive research in analytical methods, addressing over-dispersion in the design of clinical trials has received much less attention. In this study…
View article: Considering Over-Dispersion in the Sample Size Calculation for Clinical Trials With Repeated Count Measurements
Considering Over-Dispersion in the Sample Size Calculation for Clinical Trials With Repeated Count Measurements Open
Over-dispersed count variables are frequently encountered in biomedical research. Despite extensive research in analytical methods, addressing over-dispersion in the design of clinical trials has received much less attention. In this study…