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View article: Sertindole inhibits autophagic flux and glioma progression
Sertindole inhibits autophagic flux and glioma progression Open
Gliomas, the most lethal brain tumors, often exhibit resistance to conventional chemotherapy and/or radiotherapy. This study reveals that sertindole, a potent dopamine D2 receptor antagonist primarily designed as an antipsychotic medicatio…
View article: Gemin6 promotes c‐Myc stabilisation and non‐small cell lung cancer progression via accelerating AURKB mRNA maturation
Gemin6 promotes c‐Myc stabilisation and non‐small cell lung cancer progression via accelerating AURKB mRNA maturation Open
Lung cancer is the leading cause of cancer death worldwide, and around 85% of patients are grouped into non-small cell lung cancer (NSCLC) based on the histological characteristics.1 The survival of motor neurons (SMN) complex has been dem…
View article: Research progress of Bub3 gene in malignant tumors
Research progress of Bub3 gene in malignant tumors Open
The spindle assembly checkpoint (SAC) is a highly conserved monitoring system that ensures a fidelity of chromosome segregation during mitosis. Bub3, a mitotic Checkpoint Protein, is a member of the Bub protein family, and an important fac…
View article: PirB functions as an intrinsic suppressor in hippocampal neural stem cells
PirB functions as an intrinsic suppressor in hippocampal neural stem cells Open
Neural stem cells play pivotal roles during prenatal development and throughout life. Here, we report that Paired immunoglobulin-like receptor B (PirB) functions as a suppressor during brain neurogenesis in the adult mouse. PirB expression…
View article: Pyrrolo [3,4-b]-quinolin-9-amine compound FZU-0038-056 suppresses triple-negative breast cancer partially through inhibiting the expression of Bcl-2
Pyrrolo [3,4-b]-quinolin-9-amine compound FZU-0038-056 suppresses triple-negative breast cancer partially through inhibiting the expression of Bcl-2 Open
Triple-negative breast cancer (TNBC) has a poorer prognosis than other subtypes of breast cancer; however, it lacks effective targeted therapies clinically. In this study, we found FZU-0038-056, a novel compound derived from last-stage fun…
View article: PAQR4 promotes chemoresistance in non-small cell lung cancer through inhibiting Nrf2 protein degradation
PAQR4 promotes chemoresistance in non-small cell lung cancer through inhibiting Nrf2 protein degradation Open
Purpose: Lung cancer is the leading cause of cancer related deaths worldwide. We have previously identified many differentially expressed genes (DEGs) from large scale pan-cancer dataset using the Cross-Value Association Analysis (CVAA) me…