Explanipedia

Spatiotemporal single-cell roadmap of human skin wound healing Open

Zhuang Liu, Xiaowei Bian, Lihua Luo, Åsa K. Björklund, Li Li , et al. · 2024

Wound healing is vital for human health, yet the details of cellular dynamics and coordination in human wound repair remain largely unexplored. To address this, we conducted single-cell multi-omics analyses on human skin wound tissues thro…

Author Correction: Cutaneous T cell lymphoma atlas reveals malignant TH2 cells supported by a B cell-rich tumor microenvironment Open

Ruoyan Li, Johanna Strobl, Elizabeth Poyner, Aya Balbaa, Fereshteh Torabi , et al. · 2024

A multi-omic atlas of human embryonic skeletal development Open

Ken To, Lijiang Fei, J. Patrick Pett, Kenny Roberts, Raphaël Blain , et al. · 2024

Human embryonic bone and joint formation is determined by coordinated differentiation of progenitors in the nascent skeleton. The cell states, epigenetic processes and key regulatory factors that underlie lineage commitment of these cells …

Cutaneous T cell lymphoma atlas reveals malignant TH2 cells supported by a B cell-rich tumor microenvironment Open

Ruoyan Li, Johanna Strobl, Elizabeth Poyner, Aya Balbaa, Fereshteh Torabi , et al. · 2024

A prenatal skin atlas reveals immune regulation of human skin morphogenesis Open

Nusayhah Hudaa Gopee, Elena Winheim, Bayanne Olabi, Chloe Admane, April Foster , et al. · 2024

Human prenatal skin is populated by innate immune cells, including macrophages, but whether they act solely in immunity or have additional functions in morphogenesis is unclear. Here we assembled a comprehensive multi-omics reference atlas…

Cutaneous T cell lymphoma atlas reveals malignant Th2 cells supported by a B cell-rich microenvironment Open

Ruoyan Li, Johanna Strobl, Elizabeth Poyner, Fereshteh Torabi, Pasha Mazin , et al. · 2023

Cutaneous T-cell lymphoma (CTCL) is a potentially fatal clonal malignancy of T cells primarily affecting the skin. The most common form of CTCL, mycosis fungoides (MF), can be difficult to diagnose resulting in treatment delay. The pathoge…

A human prenatal skin cell atlas reveals immune cell regulation of skin morphogenesis Open

Nusayhah Hudaa Gopee, Ni Huang, Bayanne Olabi, Chloe Admane, Rachel A. Botting , et al. · 2023

Summary Human prenatal skin is populated by innate immune cells including macrophages, and whether they act solely in immunity or have additional functions in morphogenesis is unclear. We assembled the first comprehensive multi-omic refere…

Yolk sac cell atlas reveals multiorgan functions during human early development Open

Issac Goh, Rachel A. Botting, Antony Rose, Simone Webb, Justin Engelbert , et al. · 2023

The extraembryonic yolk sac (YS) ensures delivery of nutritional support and oxygen to the developing embryo but remains ill-defined in humans. We therefore assembled a comprehensive multiomic reference of the human YS from 3 to 8 postconc…

WebAtlas pipeline for integrated single cell and spatial transcriptomic data Open

Tong Li, Dave Horsfall, Daniela Basurto-Lozada, Kenny Roberts, Martin Prete , et al. · 2023

Single cell and spatial transcriptomics illuminate complementary features of tissues. However, online dissemination and exploration of integrated datasets is challenging due to the heterogeneity and scale of data. We introduce the WebAtlas…

OME-Zarr: a cloud-optimized bioimaging file format with international community support Open

Josh Moore, Daniela Basurto-Lozada, Sébastien Besson, John Bogovic, Jordão Bragantini , et al. · 2023

A growing community is constructing a next-generation file format (NGFF) for bioimaging to overcome problems of scalability and heterogeneity. Organized by the Open Microscopy Environment (OME), individuals and institutes across diverse mo…

Single-cell atlas of human liver development reveals pathways directing hepatic cell fates Open

Brandon T. Wesley, Alexander Ross, Daniele Muraro, Zhichao Miao, Sarah H. Saxton , et al. · 2022

Multi-organ functions of yolk sac during human early development Open

R Botting, Issac Goh, Antony Rose, Simone Webb, Justin Engelbert , et al. · 2022

The yolk sac (YS) represents an evolutionarily-conserved extraembryonic structure that ensures timely delivery of nutritional support and oxygen to the developing embryo. However, the YS remains ill-defined in humans. We therefore assemble…

Mapping the developing human immune system across organs Open

Chenqu Suo, Emma Dann, Issac Goh, Laura Jardine, Vitalii Kleshchevnikov , et al. · 2022

Single-cell genomics studies have decoded the immune cell composition of several human prenatal organs but were limited in describing the developing immune system as a distributed network across tissues. We profiled nine prenatal tissues c…

In Private, Secure, Conversational FinBots We Trust Open

Magdalene Ng, Kovila Coopamootoo, Tasos Spiliotopoulos, Dave Horsfall, Mhairi Aitken , et al. · 2022

In the past decade, the financial industry has experienced a technology revolution. While we witness a rapid introduction of conversational bots for financial services, there is a lack of understanding of conversational user interfaces (CU…

Know Your Customer: Balancing Innovation and Regulation for Financial Inclusion Open

Karen Elliott, Kovila Coopamootoo, Edward M. Curran, Paul Ezhilchelvan, Samantha Finnigan , et al. · 2021

Financial inclusion depends on providing adjusted services for citizens with disclosed vulnerabilities. At the same time, the financial industry needs to adhere to a strict regulatory framework, which is often in conflict with the desire f…

Blood and immune development in human fetal bone marrow and Down syndrome Open

Laura Jardine, Simone Webb, Issac Goh, Mariana Quiroga Londoño, Gary Reynolds , et al. · 2021

Intrinsic and extrinsic regulation of human fetal bone marrow haematopoiesis and perturbations in Down syndrome Open

Laura Jardine, Simone Webb, Issac Goh, Mariana Quiroga Londoño, Gary Reynolds , et al. · 2021

Throughout postnatal life, haematopoiesis in the bone marrow (BM) maintains blood and immune cell production. Haematopoiesis first emerges in human BM at 12 post conception weeks while fetal liver (FL) haematopoiesis is still expanding. Ye…

Identifying and Supporting Financially Vulnerable Consumers in a Privacy-Preserving Manner: A Use Case Using Decentralised Identifiers and Verifiable Credentials Open

Tasos Spiliotopoulos, Dave Horsfall, Magdalene Ng, Kovila Coopamootoo, Aad van Moorsel , et al. · 2021

Vulnerable individuals have a limited ability to make reasonable financial decisions and choices and, thus, the level of care that is appropriate to be provided to them by financial institutions may be different from that required for othe…

Identifying and Supporting Financially Vulnerable Consumers in a\n Privacy-Preserving Manner: A Use Case Using Decentralised Identifiers and\n Verifiable Credentials Open

Tasos Spiliotopoulos, Dave Horsfall, Magdalene Ng, Kovila Coopamootoo, Aad van Moorsel , et al. · 2021

Vulnerable individuals have a limited ability to make reasonable financial\ndecisions and choices and, thus, the level of care that is appropriate to be\nprovided to them by financial institutions may be different from that required\nfor o…

Single-cell multi-omics analysis of the immune response in COVID-19 Open

Emily Stephenson, Gary Reynolds, Rachel A. Botting, Fernando J. Calero‐Nieto, Michael D. Morgan , et al. · 2021

Analysis of human blood immune cells provides insights into the coordinated response to viral infections such as severe acute respiratory syndrome coronavirus 2, which causes coronavirus disease 2019 (COVID-19). We performed single-cell tr…

The cellular immune response to COVID-19 deciphered by single cell multi-omics across three UK centres Open

Emily Stephenson, Gary Reynolds, Rachel A. Botting, Fernando J. Calero‐Nieto, Michael D. Morgan , et al. · 2021

The COVID-19 pandemic, caused by SARS coronavirus 2 (SARS-CoV-2), has resulted in excess morbidity and mortality as well as economic decline. To characterise the systemic host immune response to SARS-CoV-2, we performed single-cell RNA-seq…

Poised cell circuits in human skin are activated in disease Open

Gary Reynolds, Péter Végh, James Fletcher, Elizabeth Poyner, Emily Stephenson , et al. · 2020

The human skin confers biophysical and immunological protection through a complex cellular network that is established early in development. We profiled ~500,000 single cells using RNA-sequencing from healthy adult and developing skin, and…

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