David Lowe
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View article: Defining the relationships among four tests for assessing antibody-mediated rejection in heart transplants in a prospective, observational study
Defining the relationships among four tests for assessing antibody-mediated rejection in heart transplants in a prospective, observational study Open
These inter-test relationships will be useful in guiding ABMR management, including monitoring of treatment responses and relapses, especially when discrepancies occur.
View article: THE WIGNER DISTRIBUTION AS A SPEECH SIGNAL PROCESSING TOOL
THE WIGNER DISTRIBUTION AS A SPEECH SIGNAL PROCESSING TOOL Open
View article: Human leukocyte antigen epitope definition using site-directed mutagenesis
Human leukocyte antigen epitope definition using site-directed mutagenesis Open
View article: Site‐directed mutagenesis of <scp>HLA</scp> molecules reveals the functional epitope of a human <scp>HLA‐A1</scp>/<scp>A36</scp>‐specific monoclonal antibody
Site‐directed mutagenesis of <span>HLA</span> molecules reveals the functional epitope of a human <span>HLA‐A1</span>/<span>A36</span>‐specific monoclonal antibody Open
Eplet 44KM is currently listed in the HLA Epitope Registry but does not adhere to the eplet definition of an amino acid configuration within a 3.5 Å radius. Eplet 44KM has been previously redefined to the antibody‐verified reactivity patte…
View article: Dynamic Behaviour of Donor Specific Antibodies in the Early Period Following HLA Incompatible Kidney Transplantation
Dynamic Behaviour of Donor Specific Antibodies in the Early Period Following HLA Incompatible Kidney Transplantation Open
In HLA-incompatible kidney transplantation, monitoring donor-specific antibodies (DSA) plays a crucial role in providing appropriate treatment and increases kidney survival times. This work aimed to determine if early post-transplant DSA d…
View article: Estimating alloantibody levels in highly sensitized renal allograft candidates: Using serial dilutions to demonstrate a treatment effect in clinical trials
Estimating alloantibody levels in highly sensitized renal allograft candidates: Using serial dilutions to demonstrate a treatment effect in clinical trials Open
Small reductions in calculated panel-reactive antibody (cPRA) are associated with increased kidney transplantation in 100% cPRA patients. However, the high level of antibody in these patients is such that desensitization may reduce antibod…
View article: Direct quantitative measurement of the kinetics of HLA-specific antibody interactions with isolated HLA proteins
Direct quantitative measurement of the kinetics of HLA-specific antibody interactions with isolated HLA proteins Open
View article: A new data-driven model for post-transplant antibody dynamics in high risk kidney transplantation
A new data-driven model for post-transplant antibody dynamics in high risk kidney transplantation Open
The dynamics of donor specific human leukocyte antigen antibodies during early stage after kidney transplantation are of great clinical interest as these antibodies are considered to be associated with short and long term clinical outcomes…
View article: Outcomes Following Minimally Invasive Implantation of a Centrifugal Continuous-Flow Left Ventricular Assist Device
Outcomes Following Minimally Invasive Implantation of a Centrifugal Continuous-Flow Left Ventricular Assist Device Open
View article: Subclass analysis of donor<scp>HLA</scp>‐specific IgG in antibody‐incompatible renal transplantation reveals a significant association of IgG<sub>4</sub>with rejection and graft failure
Subclass analysis of donor<span>HLA</span>‐specific IgG in antibody‐incompatible renal transplantation reveals a significant association of IgG<sub>4</sub>with rejection and graft failure Open
Donor HLA-specific antibodies (DSAs) can cause rejection and graft loss after renal transplantation, but their levels measured by the current assays are not fully predictive of outcomes. We investigated whether IgG subclasses of DSA were a…
View article: An Information Taxonomy for Remotely-Accessible Engineering Instructional Laboratories
An Information Taxonomy for Remotely-Accessible Engineering Instructional Laboratories Open
An Information Taxonomy for Remote Engineering Instructional LaboratoriesThis paper introduces an information taxonomy for remote engineering instructionallaboratories. A taxonomy within some given domain organizes and clarifies the domain…
View article: Novel data-driven stochastic model for antibody dynamics in kidney transplantation∗∗This work has been supported by EPSRC UK (EP/K02504X/1).
Novel data-driven stochastic model for antibody dynamics in kidney transplantation∗∗This work has been supported by EPSRC UK (EP/K02504X/1). Open
Falls in the serum levels of donor specific HLA antibodies (DSA) after kidney transplantation are of great clinical interest, as they are associated with resolution of rejection and good long term outcomes in patients at high risk of graft…