David A. A. Baranger
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View article: Youth Correlates of Genetic Liability to Substance Use Disorders
Youth Correlates of Genetic Liability to Substance Use Disorders Open
Substance use disorders (SUDs) are moderately-highly heritable and develop in stages that typically begin in adolescence/young adulthood. It remains unclear whether SUD correlates reflect predispositional risk and/or arise as consequences …
View article: Psychiatric genome-wide association study enrichment shows promise for future psychopharmaceutical discoveries
Psychiatric genome-wide association study enrichment shows promise for future psychopharmaceutical discoveries Open
Background Innovation in psychiatric therapeutics has stagnated on known mechanisms. Psychiatric genome-wide association studies (GWAS) have identified hundreds of genome-wide significant (GWS) loci that have rapidly advanced our understan…
View article: A Phenome-Wide association study (PheWAS) of genetic risk for C-reactive protein in children of European Ancestry: Results from the ABCD study
A Phenome-Wide association study (PheWAS) of genetic risk for C-reactive protein in children of European Ancestry: Results from the ABCD study Open
View article: Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits
Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits Open
Genetic research on nicotine dependence has utilized multiple assessments that are in weak agreement. We conducted a genome-wide association study of nicotine dependence defined using the Diagnostic and Statistical Manual of Mental Disorde…
View article: Enhancing task fMRI individual difference research with neural signatures
Enhancing task fMRI individual difference research with neural signatures Open
Task-based functional magnetic resonance imaging (tb-fMRI) has advanced our understanding of brain-behavior relationships. Standard tb-fMRI analyses suffer from limited reliability and low effect sizes, and machine learning (ML) approaches…
View article: Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits
Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits Open
Background Genetic research on nicotine dependence has utilized multiple assessments that are in weak agreement. Methods We conducted a genome-wide association study (GWAS) of nicotine dependence defined using the Diagnostic and Statistica…
View article: Neuroanatomical Variability and Substance Use Initiation in Late Childhood and Early Adolescence
Neuroanatomical Variability and Substance Use Initiation in Late Childhood and Early Adolescence Open
Importance The extent to which neuroanatomical variability associated with early substance involvement, which is associated with subsequent risk for substance use disorder development, reflects preexisting risk and/or consequences of subst…
View article: Associations between prenatal caffeine exposure and child development: Longitudinal results from the Adolescent Brain Cognitive Development (ABCD) Study
Associations between prenatal caffeine exposure and child development: Longitudinal results from the Adolescent Brain Cognitive Development (ABCD) Study Open
View article: Associations between polygenic scores for cognitive and non-cognitive factors of educational attainment and measures of behavior, psychopathology, and neuroimaging in the adolescent brain cognitive development study
Associations between polygenic scores for cognitive and non-cognitive factors of educational attainment and measures of behavior, psychopathology, and neuroimaging in the adolescent brain cognitive development study Open
Background Educational attainment (EduA) is correlated with life outcomes, and EduA itself is influenced by both cognitive and non-cognitive factors. A recent study performed a ‘genome-wide association study (GWAS) by subtraction,’ subtrac…
View article: Kappa opioids inhibit spinal output neurons to suppress itch
Kappa opioids inhibit spinal output neurons to suppress itch Open
Itch is a protective sensation that drives scratching. Although specific cell types have been proposed to underlie itch, the neural basis for itch remains unclear. Here, we used two-photon Ca 2+ imaging of the dorsal horn to visualize neur…
View article: A Phenome-Wide Association Study (PheWAS) of Genetic Risk for C-Reactive Protein in Children of European Ancestry: Results From the ABCD Study
A Phenome-Wide Association Study (PheWAS) of Genetic Risk for C-Reactive Protein in Children of European Ancestry: Results From the ABCD Study Open
BACKGROUND C-reactive protein (CRP) is a moderately heritable marker of systemic inflammation that is associated with adverse physical and mental health outcomes. Identifying factors associated with genetic liability to elevated CRP in chi…
View article: Prenatal cannabis exposure, the brain, and psychopathology during early adolescence
Prenatal cannabis exposure, the brain, and psychopathology during early adolescence Open
View article: Cross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking
Cross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking Open
Individuals with schizophrenia frequently experience co-occurring substance use, including tobacco smoking and heavy cannabis use, and substance use disorders. There is interest in understanding the extent to which these relationships are …
View article: Associations between prenatal caffeine exposure and child development: Longitudinal results from the Adolescent Brain Cognitive Development (ABCD) Study
Associations between prenatal caffeine exposure and child development: Longitudinal results from the Adolescent Brain Cognitive Development (ABCD) Study Open
Objective Though caffeine use during pregnancy is common, its longitudinal associations with child behavioral and physical health outcomes remain poorly understood. Here, we estimated associations between prenatal caffeine exposure, body m…
View article: Alcohol milestones and internalizing, externalizing, and executive function: longitudinal and polygenic score associations
Alcohol milestones and internalizing, externalizing, and executive function: longitudinal and polygenic score associations Open
Background Although the link between alcohol involvement and behavioral phenotypes (e.g. impulsivity, negative affect, executive function [EF]) is well-established, the directionality of these associations, specificity to stages of alcohol…
View article: Neuroanatomical variability associated with early substance use initiation: Results from the ABCD Study
Neuroanatomical variability associated with early substance use initiation: Results from the ABCD Study Open
The extent to which neuroanatomical variability associated with substance involvement reflects pre-existing risk and/or consequences of substance exposure remains poorly understood. In the Adolescent Brain Cognitive Development SM (ABCD®) …
View article: Cross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking
Cross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking Open
Individuals with schizophrenia frequently experience co-occurring substance use, including tobacco smoking and heavy cannabis use, and substance use disorders. There is interest in understanding the extent to which these relationships are …
View article: Evaluating Evidence Supporting an Effect of Prenatal Cannabis Exposure on White Matter Integrity
Evaluating Evidence Supporting an Effect of Prenatal Cannabis Exposure on White Matter Integrity Open
View article: Psychiatric Genome-wide Association Study Enrichment Shows Promise for Future Psychopharmaceutical Discoveries
Psychiatric Genome-wide Association Study Enrichment Shows Promise for Future Psychopharmaceutical Discoveries Open
Innovation in psychiatric therapeutics has stagnated on a handful of known mechanisms. Psychiatric genome-wide association studies (GWASs) have begun to identify hundreds of genome-wide significant (GWS) loci and characterize complex polyg…
View article: Associations Between Polygenic Scores for Cognitive and Non-cognitive Factors of Educational Attainment and Measures of Behavior, Psychopathology, and Neuroimaging in the Adolescent Brain Cognitive Development Study
Associations Between Polygenic Scores for Cognitive and Non-cognitive Factors of Educational Attainment and Measures of Behavior, Psychopathology, and Neuroimaging in the Adolescent Brain Cognitive Development Study Open
Background Both cognitive and non-cognitive (e.g., traits like curiosity) factors are critical for social and emotional functioning and independently predict educational attainment. These factors are heritable and genetically correlated wi…
View article: Identification of a convergent spinal neuron population that encodes itch
Identification of a convergent spinal neuron population that encodes itch Open
Summary Itch is a protective sensation that drives scratching. Although specific cell types have been proposed to underlie itch, the neural circuit basis for itch remains unclear. Here, we used two-photon Ca 2+ imaging of the dorsal horn t…
View article: Prenatal cannabis exposure is associated with localized brain differences that partially mediate associations with increased adolescent psychopathology
Prenatal cannabis exposure is associated with localized brain differences that partially mediate associations with increased adolescent psychopathology Open
Prenatal cannabis exposure (PCE) is associated with mental health problems, but the neurobiological mechanisms remain unknown. We find that PCE is associated with localized differences across neuroimaging metrics that longitudinally mediat…
View article: Accelerated neurodevelopment of reward anticipation processing in adolescent girls with depression
Accelerated neurodevelopment of reward anticipation processing in adolescent girls with depression Open
Objective To test the hypothesis that depression is associated with differential neurodevelopment of reward circuitry in adolescence. Methods Adolescent girls (N=183, 58 with MDD in early or late adolescence) underwent MRI scans from ages …
View article: Alcohol use and grey matter structure: Disentangling predispositional and causal contributions in human studies
Alcohol use and grey matter structure: Disentangling predispositional and causal contributions in human studies Open
Alcohol use is a growing global health concern and economic burden. Alcohol involvement (i.e., initiation, use, problematic use, alcohol use disorder) has been reliably associated with broad spectrum grey matter differences in cross‐sectio…
View article: Reliability of diurnal salivary cortisol metrics: A meta-analysis and investigation in two independent samples
Reliability of diurnal salivary cortisol metrics: A meta-analysis and investigation in two independent samples Open
Stress-induced dysregulation of diurnal cortisol is a cornerstone of stress-disease theories; however, observed associations between cortisol, stress, and health have been inconsistent. The reliability of diurnal cortisol features may cont…
View article: Tutorial: Power Analyses for Interaction Effects in Cross-Sectional Regressions
Tutorial: Power Analyses for Interaction Effects in Cross-Sectional Regressions Open
Interaction analyses (also termed “moderation” analyses or “moderated multiple regression”) are a form of linear regression analysis designed to test whether the association between two variables changes when conditioned on a third variabl…
View article: Characteristics Associated With Cannabis Use Initiation by Late Childhood and Early Adolescence in the Adolescent Brain Cognitive Development (ABCD) Study
Characteristics Associated With Cannabis Use Initiation by Late Childhood and Early Adolescence in the Adolescent Brain Cognitive Development (ABCD) Study Open
This cohort study evaluates characteristics associated with early-onset cannabis use.
View article: A Phenome-Wide Association Study (PheWAS) of Late Onset Alzheimer Disease Genetic Risk in Children of European Ancestry at Middle Childhood: Results from the ABCD Study
A Phenome-Wide Association Study (PheWAS) of Late Onset Alzheimer Disease Genetic Risk in Children of European Ancestry at Middle Childhood: Results from the ABCD Study Open
View article: Visualizing The Spinal Coding Of Itch
Visualizing The Spinal Coding Of Itch Open
View article: Multi‐omics cannot replace sample size in genome‐wide association studies
Multi‐omics cannot replace sample size in genome‐wide association studies Open
The integration of multi‐omics information (e.g., epigenetics and transcriptomics) can be useful for interpreting findings from genome‐wide association studies (GWAS). It has been suggested that multi‐omics could circumvent or greatly redu…