David A. Figge
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View article: Colonocytes targeted by Citrobacter rodentium elicit epithelial MHCII-restricted help from CD4 T cells 2044
Colonocytes targeted by Citrobacter rodentium elicit epithelial MHCII-restricted help from CD4 T cells 2044 Open
Description IL-22+ CD4 T cells play a key role in intestinal defense against the murine pathogen Citrobacter rodentium (C.r), yet the direct interactions between T cells and intestinal epithelial cells (IECs) remains unclear. Our study sho…
View article: Distal colonocytes targeted by C. rodentium recruit T-cell help for barrier defence
Distal colonocytes targeted by C. rodentium recruit T-cell help for barrier defence Open
Interleukin 22 (IL-22) has a non-redundant role in immune defence of the intestinal barrier 1–3 . T cells, but not innate lymphoid cells, have an indispensable role in sustaining the IL-22 signalling that is required for the protection of …
View article: Differential activation states of direct pathway striatal output neurons associated with the development of L-DOPA-induced dyskinesia
Differential activation states of direct pathway striatal output neurons associated with the development of L-DOPA-induced dyskinesia Open
L-DOPA-induced dyskinesia (LID) is a debilitating motor side effect arising from chronic dopamine replacement therapy with L-DOPA for the treatment of Parkinson disease (PD). The emergence of LID is linked to heightened sensitivity of stri…
View article: IL-2–induced Stat3 Signaling is Critical for Effector Treg Cell Programming
IL-2–induced Stat3 Signaling is Critical for Effector Treg Cell Programming Open
Maintenance of immune homeostasis to the intestinal mictrobiota is dependent on a population of effector regulatory T (eTreg) cells that develop from microbiota-reactive induced (i)Treg cells. A cardinal feature of eTreg cells is their pro…
View article: A novel subset of colonocytes targeted by Citrobacter rodentium elicits epithelial MHCII-restricted help from CD4 T cells
A novel subset of colonocytes targeted by Citrobacter rodentium elicits epithelial MHCII-restricted help from CD4 T cells Open
Interleukin (IL)-22 plays a non-redundant role in immune defense of the intestinal barrier1–3. We recently discovered an indispensable role for T cells, but not ILCs, in sustaining IL-22 signaling required for protection of colonic crypts …
View article: A novel subset of colonocytes targeted by<i>Citrobacter rodentium</i>elicits epithelial MHCII-restricted help from CD4 T cells
A novel subset of colonocytes targeted by<i>Citrobacter rodentium</i>elicits epithelial MHCII-restricted help from CD4 T cells Open
Interleukin (IL)-22 plays a non-redundant role in immune defense of the intestinal barrier 1–3 . We recently discovered an indispensable role for T cells, but not ILCs, in sustaining IL-22 signaling required for protection of colonic crypt…
View article: The divergence of PD-1+CXCR5+CD4+ T cell differentiation and stage-specific regulation of GC-Tfh cells
The divergence of PD-1+CXCR5+CD4+ T cell differentiation and stage-specific regulation of GC-Tfh cells Open
T follicular helper (Tfh) cells were discovered as CD4+ T cells in the B cell follicles that express CXCR5 and help germinal center (GC) B cell responses. However, it is not clear which PD-1+CXCR5+Bcl6+CD4+ T cells will differentiate into …
View article: Dynamic DNA Methylation Regulates Levodopa-Induced Dyskinesia
Dynamic DNA Methylation Regulates Levodopa-Induced Dyskinesia Open
Levodopa-induced dyskinesia (LID) develops after repeated levodopa (l-DOPA) exposure in Parkinson disease patients and remains one of the primary obstacles to effective treatment. LID behaviors are a consequence of striatal neuron sensitiz…