Rex A. Hess
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View article: A hidden protamine PTM code in sperm generates heterogeneous chromatin states and finetunes reproductive fitness
A hidden protamine PTM code in sperm generates heterogeneous chromatin states and finetunes reproductive fitness Open
Traditionally, the sperm genome is thought to be packaged by protamines into a uniformly compact and inert chromatin structure. Here, we challenge this long-standing view by demonstrating that protamine post-translational modifications (PT…
View article: ARL13B controls male reproductive tract physiology through primary and Motile Cilia
ARL13B controls male reproductive tract physiology through primary and Motile Cilia Open
ARL13B is a small regulatory GTPase that controls ciliary membrane composition in both motile cilia and non-motile primary cilia. In this study, we investigated the role of ARL13B in the efferent ductules, tubules of the male reproductive …
View article: PTBP1 mediates Sertoli cell actin cytoskeleton organization by regulating alternative splicing of actin regulators
PTBP1 mediates Sertoli cell actin cytoskeleton organization by regulating alternative splicing of actin regulators Open
Spermatogenesis is a biological process within the testis that produces haploid spermatozoa for the continuity of species. Sertoli cells are somatic cells in the seminiferous epithelium that orchestrate spermatogenesis. Cyclic reorganizati…
View article: Inhibition of testicular development by suppressing neonatal LH rise in male domestic pigs
Inhibition of testicular development by suppressing neonatal LH rise in male domestic pigs Open
The neonatal increase in circulating luteinizing hormone (LH) is crucial for testicular development. In male pigs, blood LH levels start to increase approximately 1 week after birth and return to basal level by 5-6 weeks of age. This study…
View article: Human efferent ductules and epididymis display unique cell lineages with motile and primary cilia
Human efferent ductules and epididymis display unique cell lineages with motile and primary cilia Open
Background Previous research has illustrated the role of cilia as mechanical and sensory antennae in various organs within the mammalian male reproductive system across different developmental stages. Despite their significance in both org…
View article: Male animal sterilization: history, current practices, and potential methods for replacing castration
Male animal sterilization: history, current practices, and potential methods for replacing castration Open
Sterilization and castration have been synonyms for thousands of years. Making an animal sterile meant to render them incapable of producing offspring. Castration or the physical removal of the testes was discovered to be the most simple b…
View article: PTBP1 mediates Sertoli cell actin cytoskeleton organization by regulating alternative splicing of actin regulators
PTBP1 mediates Sertoli cell actin cytoskeleton organization by regulating alternative splicing of actin regulators Open
Spermatogenesis is a biological process within the testis that produces haploid spermatozoa for the continuity of species. Sertoli cells are somatic cells in the seminiferous epithelium that orchestrate spermatogenesis. Cyclic reorganizati…
View article: Role for Nongenomic Estrogen Signaling in Male Fertility
Role for Nongenomic Estrogen Signaling in Male Fertility Open
Estrogen actions are mediated by both nuclear (n) and membrane (m) localized estrogen receptor 1 (ESR1). Male Esr1 knockout (Esr1KO) mice lacking functional Esr1 are infertile, with reproductive tract abnormalities. Male mice expressing nE…
View article: MIWI N-terminal RG motif promotes efficient pachytene piRNA production and spermatogenesis independent of LINE1 transposon silencing
MIWI N-terminal RG motif promotes efficient pachytene piRNA production and spermatogenesis independent of LINE1 transposon silencing Open
PIWI proteins and their associated piRNAs act to silence transposons and promote gametogenesis. Murine PIWI proteins MIWI, MILI, and MIWI2 have multiple arginine and glycine (RG)-rich motifs at their N-terminal domains. Despite being known…
View article: FRI384 Sterilization Of Female Dogs By A Neonatal Treatment Of Estrogen-Releasing Implants
FRI384 Sterilization Of Female Dogs By A Neonatal Treatment Of Estrogen-Releasing Implants Open
Disclosure: C. Park: None. P. Lin: None. S. Zhou: None. R.A. Hess: None. C. Ko: None. Hypothalamic Kisspeptin neurons that control the GnRH neuron activity are known to be a core regulator of the reproductive axis. Loss of the Kisspeptin-1…
View article: DNALI1 interacts with the MEIG1/PACRG complex within the manchette and is required for proper sperm flagellum assembly in mice
DNALI1 interacts with the MEIG1/PACRG complex within the manchette and is required for proper sperm flagellum assembly in mice Open
The manchette is a transient and unique structure present in elongating spermatids and required for proper differentiation of the germ cells during spermatogenesis. Previous work indicated that the MEIG1/PACRG complex locates in the manche…
View article: DNALI1 interacts with the MEIG1/PACRG complex within the manchette and is required for proper sperm flagellum assembly in mice
DNALI1 interacts with the MEIG1/PACRG complex within the manchette and is required for proper sperm flagellum assembly in mice Open
The manchette is a transient and unique structure present in elongating spermatids and required for proper differentiation of the germ cells during spermatogenesis. Previous work indicated that the MEIG1/PACRG complex locates in the manche…
View article: Disrupted intercellular bridges and spermatogenesis in fatty <scp>acyl‐CoA</scp> reductase 1 knockout mice: A new model of ether lipid deficiency
Disrupted intercellular bridges and spermatogenesis in fatty <span>acyl‐CoA</span> reductase 1 knockout mice: A new model of ether lipid deficiency Open
Peroxisomal fatty acyl‐CoA reductase 1 (FAR1) is a rate‐limiting enzyme for ether lipid (EL) synthesis. Gene mutations in FAR1 cause a rare human disease. Furthermore, altered EL homeostasis has also been associated with various prevalent …
View article: Author response: DNALI1 interacts with the MEIG1/PACRG complex within the manchette and is required for proper sperm flagellum assembly in mice
Author response: DNALI1 interacts with the MEIG1/PACRG complex within the manchette and is required for proper sperm flagellum assembly in mice Open
Full text Figures and data Side by side Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The man…
View article: Expression patterns of sex steroid receptors in developing mesonephros of the male mouse: three-dimensional analysis
Expression patterns of sex steroid receptors in developing mesonephros of the male mouse: three-dimensional analysis Open
The androgen pathway via androgen receptor (AR) has received the most attention for development of male reproductive tracts. The estrogen pathway through estrogen receptor (ESR1) is also a major contributor to rete testis and efferent duct…
View article: PMON212 None-surgical sterilization of female dogs
PMON212 None-surgical sterilization of female dogs Open
Female pet dogs are sterilized by surgically removing their ovaries as a means to eliminate the source of germ cells and sex steroids. Surgical sterilization is inevitably invasive to the animals and costly to their owners, and an alternat…
View article: MEIG1/PACRG associated and non-associated functions of axonemal dynein light intermediate polypeptide 1 (DNALI1) in mammalian spermatogenesis
MEIG1/PACRG associated and non-associated functions of axonemal dynein light intermediate polypeptide 1 (DNALI1) in mammalian spermatogenesis Open
Axonemal dynein light intermediate polypeptide 1 (DNALI1) was originally cloned from Chlamydomonas reinhardtii in an effort to find motor proteins essential for flagellar motility. Here we report that DNALI1 is a binding partner of parkin …
View article: A single amino acid mutation in the mouse MEIG1 protein disrupts a cargo transport system necessary for sperm formation
A single amino acid mutation in the mouse MEIG1 protein disrupts a cargo transport system necessary for sperm formation Open
Mammalian spermatogenesis is a highly coordinated process that requires cooperation between specific proteins to coordinate diverse biological functions. For example, mouse Parkin coregulated gene (PACRG) recruits meiosis-expressed gene 1 …
View article: CEP164 is essential for efferent duct multiciliogenesis and male fertility
CEP164 is essential for efferent duct multiciliogenesis and male fertility Open
Cilia are evolutionarily conserved microtubule-based structures that perform diverse biological functions. Cilia are assembled on basal bodies and anchored to the plasma membrane via distal appendages. In the male reproductive tract, multi…
View article: Autophagy core protein ATG5 is required for elongating spermatid development, sperm individualization and normal fertility in male mice
Autophagy core protein ATG5 is required for elongating spermatid development, sperm individualization and normal fertility in male mice Open
Spermiogenesis is the longest phase of spermatogenesis, with dramatic morphological changes and a final step of spermiation, which involves protein degradation and the removal of excess cytoplasm; therefore, we hypothesized that macroautop…
View article: The Distal Appendage Protein CEP164 Is Essential for Efferent Duct Multiciliogenesis and Male Fertility
The Distal Appendage Protein CEP164 Is Essential for Efferent Duct Multiciliogenesis and Male Fertility Open
Cilia are evolutionarily conserved microtubule-based structures that perform diverse biological functions. Cilia are assembled on basal bodies and anchored to the plasma membrane via distal appendages. Multiciliated cells (MCCs) are a spec…
View article: In Memoriam: Duane L. Garner, PhD
In Memoriam: Duane L. Garner, PhD Open
Duane L. Garner, a Founding Charter Member of the American Society of Andrology, our colleague, and more importantly, our friend passed away on July 5, 2020, at his home in Graeagle, California. Looking back over his life, it is easy to se…
View article: Autophagy core protein ATG5 is required for elongating spermatid development, sperm individualization and normal fertility in male mice
Autophagy core protein ATG5 is required for elongating spermatid development, sperm individualization and normal fertility in male mice Open
Spermiogenesis is the longest phase of spermatogenesis, with dramatic morphological changes and a final step of spermiation, which involves protein degradation and the removal of excess cytoplasm; therefore, we hypothesized that macroautop…