David A. Lovejoy
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View article: Teneurin C‐Terminal Associated Peptide (<scp>TCAP</scp>)‐1 Attenuates Restraint Stress‐Induced Corticosterone Increases in Male Mice and Rats
Teneurin C‐Terminal Associated Peptide (<span>TCAP</span>)‐1 Attenuates Restraint Stress‐Induced Corticosterone Increases in Male Mice and Rats Open
Hyperactivation of the hypothalamic‐pituitary‐adrenal (HPA) axis response can result in anxiety and other neuropsychiatric disorders and effective therapeutics are needed to mitigate this maladaptive response. Here we examined the effects …
View article: Teneurin C-terminal associated peptide (TCAP)-1 attenuates the development and expression of naloxone-precipitated morphine withdrawal in male Swiss Webster mice
Teneurin C-terminal associated peptide (TCAP)-1 attenuates the development and expression of naloxone-precipitated morphine withdrawal in male Swiss Webster mice Open
Rationale Corticotropin-releasing factor (CRF), the apical stress-inducing hormone, exacerbates stress and addictive behaviors. TCAP-1 is a peptide that directly inhibits both CRF-mediated stress and addiction-related behaviors; however, t…
View article: A novel role for Teneurin C-terminal Associated Peptide (TCAP) in the regulation of cardiac activity in the Sydney rock oyster, Saccostrea glomerata
A novel role for Teneurin C-terminal Associated Peptide (TCAP) in the regulation of cardiac activity in the Sydney rock oyster, Saccostrea glomerata Open
Teneurin C-terminal associated peptide (TCAP) is an ancient bioactive peptide that is highly conserved in metazoans. TCAP administration reduces cellular and behavioural stress in vertebrate and urochordate models, yet despite numerous stu…
View article: Skeletal muscle metabolism and contraction performance regulation by teneurin C-terminal-associated peptide-1
Skeletal muscle metabolism and contraction performance regulation by teneurin C-terminal-associated peptide-1 Open
Skeletal muscle regulation is responsible for voluntary muscular movement in vertebrates. The genes of two essential proteins, teneurins and latrophilins (LPHN), evolving in ancestors of multicellular animals form a ligand-receptor pair, a…
View article: Teneurin and TCAP Phylogeny and Physiology: Molecular Analysis, Immune Activity, and Transcriptomic Analysis of the Stress Response in the Sydney Rock Oyster (Saccostrea glomerata) Hemocytes
Teneurin and TCAP Phylogeny and Physiology: Molecular Analysis, Immune Activity, and Transcriptomic Analysis of the Stress Response in the Sydney Rock Oyster (Saccostrea glomerata) Hemocytes Open
Teneurin C-terminal associated peptide (TCAP) is an ancient bioactive peptide that is highly conserved in metazoans. TCAP administration reduces cellular and behavioral stress in vertebrate and urochordate models. There is little informati…
View article: Role of Teneurin C-Terminal Associated Peptides (TCAP) on Intercellular Adhesion and Communication
Role of Teneurin C-Terminal Associated Peptides (TCAP) on Intercellular Adhesion and Communication Open
The teneurin C-terminal associated peptides (TCAP) are encoded by the terminal exon of all metazoan teneurin genes. Evidence supports the liberation of a soluble TCAP peptide either by proteolytic cleavage from the mature transmembrane ten…
View article: Regulation of skeletal muscle metabolism and contraction performance via teneurin-latrophilin action
Regulation of skeletal muscle metabolism and contraction performance via teneurin-latrophilin action Open
Skeletal muscle regulation is responsible for voluntary muscular movement in vertebrates. The genes of two essential proteins, teneurins and latrophilins (LPHN), evolving in ancestors of multicellular animals, form a ligand-receptor pair, …
View article: Editorial: The Phylogenetic History of Hypothalamic Neuromodulators
Editorial: The Phylogenetic History of Hypothalamic Neuromodulators Open
EDITORIAL article Front. Neurosci., 23 June 2021 | https://doi.org/10.3389/fnins.2021.712448
View article: Teneurin C-Terminal Associated Peptide (TCAP)-3 Increases Metabolic Activity in Zebrafish
Teneurin C-Terminal Associated Peptide (TCAP)-3 Increases Metabolic Activity in Zebrafish Open
Teneurin C-terminal associated peptides (TCAP), bioactive peptides located on the C-terminal end of teneurin proteins, have been shown to regulate stress axis functions due to the high conservation between TCAP and corticotropin releasing …
View article: Corticotropin-Releasing Factor: An Ancient Peptide Family Related to the Secretin Peptide Superfamily
Corticotropin-Releasing Factor: An Ancient Peptide Family Related to the Secretin Peptide Superfamily Open
Corticotropin-releasing factor (CRF) is the hypothalamic releasing peptide that regulates the hypothalamic-pituitary-adrenal/inter-renal (HPA/I) axis in vertebrates. Over the last 25 years, there has been considerable discussion on its par…
View article: Editorial: Origins of Human Neuropathology: The Significance of Teneurin-Latrophilin Interaction
Editorial: Origins of Human Neuropathology: The Significance of Teneurin-Latrophilin Interaction Open
EDITORIAL article Front. Neurosci., 15 May 2020Sec. Neuroendocrine Science Volume 14 - 2020 | https://doi.org/10.3389/fnins.2020.00501
View article: Synthetic Peptides as Therapeutic Agents: Lessons Learned From Evolutionary Ancient Peptides and Their Transit Across Blood-Brain Barriers
Synthetic Peptides as Therapeutic Agents: Lessons Learned From Evolutionary Ancient Peptides and Their Transit Across Blood-Brain Barriers Open
Peptides play a major role in the transmission of information to and from the central nervous system. However, because of their structural complexity, the development of pharmacological peptide-based therapeutics has been challenged by the…
View article: Activity of the Carboxy-Terminal Peptide Region of the Teneurins and Its Role in Neuronal Function and Behavior in Mammals
Activity of the Carboxy-Terminal Peptide Region of the Teneurins and Its Role in Neuronal Function and Behavior in Mammals Open
Teneurin C-terminal associated peptides (TCAPs) are an evolutionarily ancient family of 40- to 41-residue bioactive peptides located on the extracellular end of each of the four teneurin transmembrane proteins. TCAP-1 may exist as a tether…
View article: A Putative Role of Teneurin-2 and Its Related Proteins in Astrocytes
A Putative Role of Teneurin-2 and Its Related Proteins in Astrocytes Open
Teneurins are type II transmembrane proteins comprised of four phylogenetically conserved homologs (Ten-1-4) that are highly expressed during neurogenesis. An additional bioactive peptide named teneurin C-terminal-associated peptide (TCAP-…
View article: Teneurin C-Terminal Associated Peptide (TCAP)-1 and Latrophilin Interaction in HEK293 Cells: Evidence for Modulation of Intercellular Adhesion
Teneurin C-Terminal Associated Peptide (TCAP)-1 and Latrophilin Interaction in HEK293 Cells: Evidence for Modulation of Intercellular Adhesion Open
The teneurins are a family of four transmembrane proteins essential to intercellular adhesion processes, and are required for the development and maintenance of tissues. The Adhesion G protein-coupled receptor (GPCR) subclass latrophilins …
View article: Teneurin-2 presence in rat and human odontoblasts
Teneurin-2 presence in rat and human odontoblasts Open
Teneurins are transmembrane proteins consisting of four paralogues (Ten-1-4), notably expressed in the central nervous system during development. All teneurins contain a bioactive peptide in their carboxyl terminal named teneurin C-termina…
View article: Anatomical Organization of Urocortin 3-Synthesizing Neurons and Immunoreactive Terminals in the Central Nervous System of Non-Human Primates [Sapajus spp.]
Anatomical Organization of Urocortin 3-Synthesizing Neurons and Immunoreactive Terminals in the Central Nervous System of Non-Human Primates [Sapajus spp.] Open
Urocortin 3 (UCN3) is a neuropeptide member of the corticotropin-releasing factor (CRF) peptide family that acts as a selective endogenous ligand for the CRF, subtype 2 (CRF2) receptor. Immunohistochemistry and in situ hybridization data f…
View article: Teneurins, TCAP, and latrophilins: roles in the etiology of mood disorders
Teneurins, TCAP, and latrophilins: roles in the etiology of mood disorders Open
Mood disorders, including anxiety and depression, are thought to be characterized by disrupted neuronal synapses and altered brain plasticity. The etiology is complex, involving numerous regions of the brain, comprising a multitude of neur…