David A. Lyons
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View article: FBXW7 regulates MYRF levels to control myelin capacity and homeostasis in the adult central nervous system
FBXW7 regulates MYRF levels to control myelin capacity and homeostasis in the adult central nervous system Open
Myelin, along with the oligodendrocytes (OLs) that produce it, is essential for proper central nervous system (CNS) function in vertebrates. Although the accurate targeting of myelin to axons and its maintenance are critical for CNS perfor…
View article: Activity-driven myelin sheath growth is mediated by mGluR5
Activity-driven myelin sheath growth is mediated by mGluR5 Open
Myelination by oligodendrocytes in the central nervous system is influenced by neuronal activity, but the molecular mechanisms by which this occurs have remained unclear. Here we employed pharmacological, genetic, functional imaging and op…
View article: High-resolution phenotypic screen in zebrafish identifies novel regulators of CNS axon diameter growth
High-resolution phenotypic screen in zebrafish identifies novel regulators of CNS axon diameter growth Open
Axon diameter varies up to 100-fold between distinct neurons in the central nervous system with larger axons exhibiting proportionally faster conduction velocity. Axon diameter influences myelination, can be dynamically regulated, which mi…
View article: Fast, accurate, and versatile data analysis platform for the quantification of molecular spatiotemporal signals
Fast, accurate, and versatile data analysis platform for the quantification of molecular spatiotemporal signals Open
Optical recording of intricate molecular dynamics is becoming an indispensable technique for biological studies, accelerated by the development of new or improved biosensors and microscopy technology. This creates major computational chall…
View article: Developmental axon diameter growth of central nervous system axons does not depend on ensheathment or myelination by oligodendrocytes
Developmental axon diameter growth of central nervous system axons does not depend on ensheathment or myelination by oligodendrocytes Open
SUMMARY Myelination facilitates the rapid conduction of action potentials along axons. In the central nervous system (CNS), myelinated axons vary over 100-fold in diameter, with conduction speed scaling linearly with increasing diameter. A…
View article: FBXW7 regulates MYRF levels to control myelin capacity and homeostasis in the adult CNS
FBXW7 regulates MYRF levels to control myelin capacity and homeostasis in the adult CNS Open
Myelin, along with the oligodendrocytes (OLs) that produce it, is essential for proper central nervous system (CNS) function in vertebrates. Although the accurate targeting of myelin to axons and its maintenance are critical for CNS perfor…
View article: Fast, Accurate, and Versatile Data Analysis Platform for the Quantification of Molecular Spatiotemporal Signals
Fast, Accurate, and Versatile Data Analysis Platform for the Quantification of Molecular Spatiotemporal Signals Open
SUMMARY Optical recording of intricate molecular dynamics is becoming an indispensable technique for biological studies, accelerated by the development of new or improved biosensors and microscopy technology. This creates major computation…
View article: C9ORF72 Deficiency Results in Neurodegeneration in the Zebrafish Retina
C9ORF72 Deficiency Results in Neurodegeneration in the Zebrafish Retina Open
Hexanucleotide repeat expansions within the gene C9ORF72 are the most common cause of the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). This disease-causing expansion leads to a reduction…
View article: A retroviral link to vertebrate myelination through retrotransposon-RNA-mediated control of myelin gene expression
A retroviral link to vertebrate myelination through retrotransposon-RNA-mediated control of myelin gene expression Open
Myelin, the insulating sheath that surrounds neuronal axons, is produced by oligodendrocytes in the central nervous system (CNS). This evolutionary innovation, which first appears in jawed vertebrates, enabled rapid transmission of nerve i…
View article: C9ORF72 deficiency results in degeneration of the zebrafish retina<i>in vivo</i>
C9ORF72 deficiency results in degeneration of the zebrafish retina<i>in vivo</i> Open
G4C2 Hexanucleotide repeat expansions within the gene C9ORF72 are the most common cause of the neurodegenerative diseases Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal dementia (FTD). This disease-causing expansion leads to a redu…
View article: Importin 13-dependent Axon Diameter Growth Regulates Conduction Speeds along Myelinated CNS Axons
Importin 13-dependent Axon Diameter Growth Regulates Conduction Speeds along Myelinated CNS Axons Open
Summary Central nervous system neurons have axons that vary over 100-fold in diameter. This diversity contributes to the regulation of myelination and conduction velocity along axons, which is critical for proper nervous system function. D…
View article: Oligodendrocytes form paranodal bridges that generate chains of myelin sheaths that are vulnerable to degeneration with age
Oligodendrocytes form paranodal bridges that generate chains of myelin sheaths that are vulnerable to degeneration with age Open
Myelin sheaths in the CNS are generated by the tips of oligodendrocyte processes, which wrap axons to accelerate action potential conduction, provide metabolic support and control excitability. Here we identify a distinct mode of myelinati…
View article: A retroviral origin of vertebrate myelin
A retroviral origin of vertebrate myelin Open
Myelin, the insulating sheath that surrounds neuronal axons, is produced by oligodendrocytes in the central nervous system (CNS). This evolutionary innovation, which first appears in jawed vertebrates, enabled rapid transmission of nerve i…
View article: iPSC-derived myelinoids to study myelin biology of humans
iPSC-derived myelinoids to study myelin biology of humans Open
(Developmental Cell 56, 1346–1358.e1–e6; May 3, 2021) In the originally published version of this article, in the “Generation of iPSC myelinoids” paragraph of the STAR Methods section, the authors inadvertently included typographical error…
View article: Insights Into Central Nervous System Glial Cell Formation and Function From Zebrafish
Insights Into Central Nervous System Glial Cell Formation and Function From Zebrafish Open
The term glia describes a heterogenous collection of distinct cell types that make up a large proportion of our nervous system. Although once considered the glue of the nervous system, the study of glial cells has evolved significantly in …
View article: CNS Hypomyelination Disrupts Axonal Conduction and Behavior in Larval Zebrafish
CNS Hypomyelination Disrupts Axonal Conduction and Behavior in Larval Zebrafish Open
Myelination is essential for central nervous system (CNS) formation, health and function. As a model organism, larval zebrafish have been extensively employed to investigate the molecular and cellular basis of CNS myelination, because of t…
View article: Oligodendrocyte HCN2 Channels Regulate Myelin Sheath Length
Oligodendrocyte HCN2 Channels Regulate Myelin Sheath Length Open
Oligodendrocytes generate myelin sheaths vital for the formation, health, and function of the CNS. Myelin sheath length is a key property that determines axonal conduction velocity and is known to be variable across the CNS. Myelin sheath …
View article: Clusters of neuronal Neurofascin prefigure node of Ranvier position along single axons
Clusters of neuronal Neurofascin prefigure node of Ranvier position along single axons Open
Summary The spacing of nodes of Ranvier crucially affects conduction properties along myelinated axons. It has been assumed that node position is primarily driven by the growth of myelin sheaths. Here, we reveal an additional mechanism of …
View article: CRISPR gRNA phenotypic screening in zebrafish reveals pro-regenerative genes in spinal cord injury
CRISPR gRNA phenotypic screening in zebrafish reveals pro-regenerative genes in spinal cord injury Open
Zebrafish exhibit robust regeneration following spinal cord injury, promoted by macrophages that control post-injury inflammation. However, the mechanistic basis of how macrophages regulate regeneration is poorly understood. To address thi…
View article: Central nervous system hypomyelination disrupts axonal conduction and behaviour in larval zebrafish
Central nervous system hypomyelination disrupts axonal conduction and behaviour in larval zebrafish Open
Myelination is essential for central nervous system (CNS) formation, health and function. As a model organism, larval zebrafish have been extensively employed to investigate the molecular and cellular basis of CNS myelination, due to their…
View article: Synaptic vesicle fusion along axons is driven by myelination and subsequently accelerates sheath growth in an activity-regulated manner
Synaptic vesicle fusion along axons is driven by myelination and subsequently accelerates sheath growth in an activity-regulated manner Open
To study activity-regulated myelination, we imaged synaptic vesicle fusion along single axons in living zebrafish, and found, surprisingly, that axonal synaptic vesicle fusion is driven by myelination. This myelin-induced axonal vesicle fu…