David A. Vesey
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View article: Use of Urinary β2-Microglobulin in the Assessment of the Health Risk from Environmental Cadmium Exposure
Use of Urinary β2-Microglobulin in the Assessment of the Health Risk from Environmental Cadmium Exposure Open
Cadmium (Cd) is a ubiquitous environmental pollutant with no nutritional value or physiological role in the body. It readily accumulates in various tissues as it is easily absorbed from the diet but only poorly excreted. Due to the widespr…
View article: Environmental Exposure to Cadmium and Lead Exacerbates Kidney Function in People with Diabetes
Environmental Exposure to Cadmium and Lead Exacerbates Kidney Function in People with Diabetes Open
Diabetic kidney disease and hypertension are the leading causes of kidney failure. The reduction in an estimated glomerular filtration rate (eGFR) in response to chronic exposure to low levels of cadmium (Cd) has been causally linked, howe…
View article: Use of Urinary β<sub>2</sub>-Microglobulin in the Assessment of the Health Risk from Environmental Cadmium Exposure
Use of Urinary β<sub>2</sub>-Microglobulin in the Assessment of the Health Risk from Environmental Cadmium Exposure Open
Cadmium (Cd) is a ubiquitous environmental pollutant with no nutritional value or physiological role in the body. It readily accumulates in various tissues as it is easily absorbed from the diet but only poorly excreted. Due to the widespr…
View article: Enhanced Kidney Damage in Individuals with Diabetes Who Are Chronically Exposed to Cadmium and Lead: The Emergent Role for β2-Microglobulin
Enhanced Kidney Damage in Individuals with Diabetes Who Are Chronically Exposed to Cadmium and Lead: The Emergent Role for β2-Microglobulin Open
Elevated levels of circulating β2-microglobulin (β2M) are linked to an increased risk of hypertension and mortality from diabetes. The present study tests the hypothesis that the environmental pollutants, cadmium (Cd) and lead (Pb), by inc…
View article: Kidney Damage in Diabetics Exposed to Cadmium and Lead: The Emergent Role for β2-Microglobulin
Kidney Damage in Diabetics Exposed to Cadmium and Lead: The Emergent Role for β2-Microglobulin Open
Elevated levels of circulating β2-microglobulin (β2M) are linked to an increased risk of developing hypertension and hyperglycemia. The mechanism of this association, however, remains unclear. One hypothesis which has recently gained tract…
View article: Homeostasis of β<sub>2</sub>-microglobulin in diabetics and non-diabetics with modest cadmium intoxication
Homeostasis of β<sub>2</sub>-microglobulin in diabetics and non-diabetics with modest cadmium intoxication Open
Beta-2-microglobulin (β2M) is released into plasma from nucleated cells, filtered by glomeruli, and degraded by proximal tubular cells (PTCs). Normally, < 1% of filtered β2M is excreted in urine. Intoxication of PTCs by cadmium (Cd) reduce…
View article: Biomarkers in Renal Cell Carcinoma: A Systematic Review and Immunohistochemical Validation Study
Biomarkers in Renal Cell Carcinoma: A Systematic Review and Immunohistochemical Validation Study Open
Background and Objectives: The worldwide incidence of renal cell carcinoma (RCC) rose by 22% between 2012 and 2022. In Australia, RCC accounted for 2.8% of all cancer diagnoses and contributing to 1.8% of cancer-related deaths. Identificat…
View article: Cadmium-induced nephrotoxicity assessed by benchmark dose calculations in two exposure-effect datasets
Cadmium-induced nephrotoxicity assessed by benchmark dose calculations in two exposure-effect datasets Open
Cadmium (Cd), a ubiquitous metal contaminant, accumulates preferentially in the proximal tubular cells (PTCs) of the kidneys, which can lead to tubular injury and a decline in the estimated glomerular filtration rate (eGFR). To define expo…
View article: Head-to-head comparison of tyrosine kinase inhibitors in renal cell carcinoma using patient-derived cell culture
Head-to-head comparison of tyrosine kinase inhibitors in renal cell carcinoma using patient-derived cell culture Open
Inter-individual variability in the responses of patient-derived RCC cultures to TKIs was seen, which may have biological and clinical significance. Future directions could build on this work to develop personalized cancer susceptibility p…
View article: Plasma Potassium Negatively Correlates With Sodium Chloride Cotransporter Abundance and Phosphorylation in Urinary Extracellular Vesicles From Patients With Chronic Kidney Disease
Plasma Potassium Negatively Correlates With Sodium Chloride Cotransporter Abundance and Phosphorylation in Urinary Extracellular Vesicles From Patients With Chronic Kidney Disease Open
Aim Using urinary extracellular vesicles (uEVs), we have demonstrated the functional ‘renal‐K switch’ mechanism (the WNK‐SPAK‐NCC pathway) in both healthy subjects and those with primary aldosteronism. The close relationship between blood …
View article: Metabolite pathway alterations identified by magnetic resonance metabolomics in a proximal tubular epithelial cell line treated with <scp>TGF</scp>‐β1
Metabolite pathway alterations identified by magnetic resonance metabolomics in a proximal tubular epithelial cell line treated with <span>TGF</span>‐β1 Open
Tubulointerstitial fibrosis is a characteristic hallmark of chronic kidney disease (CKD). Metabolic perturbations in cellular energy metabolism contribute to the pathogenesis of CKD, but the chemical contributors remain unclear. The aim of…
View article: Albuminuria in People Chronically Exposed to Low-Dose Cadmium Is Linked to Rising Blood Pressure Levels
Albuminuria in People Chronically Exposed to Low-Dose Cadmium Is Linked to Rising Blood Pressure Levels Open
Exposure to low-dose environmental pollutant cadmium (Cd) increases the risks of both albuminuria and hypertension by mechanisms which are poorly understood. Here, multiple regression and mediation analyses were applied to data from 641 Th…
View article: Albuminuria in People Chronically Exposed to Low-Dose Cadmium Is Due to Rising Blood Pressure Levels
Albuminuria in People Chronically Exposed to Low-Dose Cadmium Is Due to Rising Blood Pressure Levels Open
Exposure to low-dose environmental pollutant cadmium (Cd) increases the risks of both albuminuria and hypertension by mechanisms which are poorly understood. Here, multiple-regression and mediation analyses were applied to data from 641 Th…
View article: Albuminuria in People Chronically Exposed to Low-Dose Cadmium Is Due to Rising Blood Pressure Levels
Albuminuria in People Chronically Exposed to Low-Dose Cadmium Is Due to Rising Blood Pressure Levels Open
Exposure to low-dose environmental pollutant cadmium (Cd) increases the risks of both albuminuria and hypertension by mechanisms which are poorly understood. Here, multiple-regression and mediation analyses were applied to data from 641 Th…
View article: The NOAEL equivalent for the cumulative body burden of cadmium: focus on proteinuria as an endpoint
The NOAEL equivalent for the cumulative body burden of cadmium: focus on proteinuria as an endpoint Open
The risk of developing chronic kidney disease (CKD), signified by a decrease in the estimated glomerular filtration rate (eGFR), has been linked to long-term exposure to low levels of the metal pollutant cadmium (Cd). Proteinuria is a hall…
View article: Identifying biochemical changes in the kidney using proton nuclear magnetic resonance in an adenine diet chronic kidney disease mouse model
Identifying biochemical changes in the kidney using proton nuclear magnetic resonance in an adenine diet chronic kidney disease mouse model Open
This study aimed to investigate the metabolic changes in the kidneys in a murine adenine–diet model of chronic kidney disease (CKD). Kidney fibrosis is the common pathological manifestation across CKD aetiologies. Sustained inflammation an…
View article: Environmental Cadmium Exposure Induces an Increase in Systolic Blood Pressure by Its Effect on GFR
Environmental Cadmium Exposure Induces an Increase in Systolic Blood Pressure by Its Effect on GFR Open
Chronic exposure to the nephrotoxic metal pollutant, cadmium (Cd), has been associated with hypertension, but the mechanism by which it raises blood pressure is not understood. We hypothesize that exposure to Cd reduces the glomerular filt…
View article: PAR2 activation on human tubular epithelial cells engages converging signaling pathways to induce an inflammatory and fibrotic milieu
PAR2 activation on human tubular epithelial cells engages converging signaling pathways to induce an inflammatory and fibrotic milieu Open
Key features of chronic kidney disease (CKD) include tubulointerstitial inflammation and fibrosis. Protease activated receptor-2 (PAR2), a G-protein coupled receptor (GPCR) expressed by the kidney proximal tubular cells, induces potent pro…
View article: Modulation of Adverse Health Effects of Environmental Cadmium Exposure by Zinc and Its Transporters
Modulation of Adverse Health Effects of Environmental Cadmium Exposure by Zinc and Its Transporters Open
Zinc (Zn) is the second most abundant metal in the human body and is essential for the function of 10% of all proteins. As metals cannot be synthesized or degraded, they must be assimilated from the diet by specialized transport proteins, …
View article: Environmental Cadmium Exposure Induces an Increase in Systolic Blood Pressure Partly by Its Effect on GFR
Environmental Cadmium Exposure Induces an Increase in Systolic Blood Pressure Partly by Its Effect on GFR Open
Chronic exposure to the nephrotoxic metal pollutant, cadmium (Cd), has been associated with hypertension, but the mechanism by which it raises blood pressure is not understood. We hypothesize that exposure to Cd reduces the glomerular filt…
View article: Modulation of the Adverse Health Effects of Environmental Cadmium Exposure by Zinc and Its Transporters
Modulation of the Adverse Health Effects of Environmental Cadmium Exposure by Zinc and Its Transporters Open
Zinc (Zn) is the second most abundant metal in the human body, and is essential for the function of 10% of all proteins. As metals cannot be synthesized or degraded, they must be assimilated from diet by specialized transport proteins, whi…
View article: Chronic Environmental Exposure to Cadmium Increases Blood Pressure
Chronic Environmental Exposure to Cadmium Increases Blood Pressure Open
Chronic exposure to the nephrotoxic metal pollutant, cadmium (Cd), has been associated with the pathogenesis of hypertension, but so far, the mechanism has not been well defined. We hypothesize that exposure to Cd causes a decline in the g…
View article: Estimation of the Cadmium Nephrotoxicity Threshold from Loss of Glomerular Filtration Rate and Albuminuria
Estimation of the Cadmium Nephrotoxicity Threshold from Loss of Glomerular Filtration Rate and Albuminuria Open
Cadmium (Cd) is a pervasive, toxic environmental pollutant that preferentially accumulates in the tubular epithelium of the kidney. Current evidence suggests that the cumulative burden of Cd here leads to the progressive loss of the glomer…
View article: Estimation of the Cadmium Nephrotoxicity Threshold from Loss of GFR and Albuminuria
Estimation of the Cadmium Nephrotoxicity Threshold from Loss of GFR and Albuminuria Open
Cadmium (Cd) is a pervasive, toxic environmental pollutant that preferentially accumulates in tubular epithelium of the kidney. Current evidence suggests that the cumulative burden of Cd here leads to progress loss of the glomerular filtra…
View article: Gender Differences in the Severity of Cadmium Nephropathy
Gender Differences in the Severity of Cadmium Nephropathy Open
The excretion of β2-microglobulin (β2M) above 300 µg/g creatinine, termed tubulopathy, was regarded as the critical effect of chronic exposure to the metal pollutant cadmium (Cd). However, current evidence suggests that Cd may induce nephr…
View article: Gender Differences in the Severity of Cadmium Nephropathy
Gender Differences in the Severity of Cadmium Nephropathy Open
Excretion of β2-microglobulin (β2M) above 300 µg/g creatinine, termed tubulopathy, was regarded as the critical effect of chronic exposure to the metal pollutant cadmium (Cd). However, current evidence suggests that Cd may induce nephron a…
View article: Evidence Linking Cadmium Exposure and β2-Microglobulin to Increased Risk of Hypertension in Diabetes Type 2
Evidence Linking Cadmium Exposure and β2-Microglobulin to Increased Risk of Hypertension in Diabetes Type 2 Open
The most common causes of chronic kidney disease, diabetes, and hypertension are significant public health issues worldwide. Exposure to the heavy metal pollutant, cadmium (Cd), which is particularly damaging to the kidney, has been associ…
View article: #4344 CHANGES IN ENERGY METABOLISM IN THE KIDNEY WITH TUBULOINTERSTITIAL FIBROSIS: AN EX VIVO WHOLE TISSUE 2D-COSY APPROACH
#4344 CHANGES IN ENERGY METABOLISM IN THE KIDNEY WITH TUBULOINTERSTITIAL FIBROSIS: AN EX VIVO WHOLE TISSUE 2D-COSY APPROACH Open
Background and Aims Tubulointerstitial fibrosis is the common pathological manifestation in chronic kidney disease (CKD) and can indicate whether a patient will progress to kidney failure. The metabolic consequences of developing fibrosis …