David A. Anderson
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An Auto-Normalizing Zero-Crossing Detection System for Wearable Garment-Based Respiratory Rate Monitoring Open
Monitoring respiratory rates is critical in understanding and predicting medical events but has proven difficult to reliably and noninvasively measure. Previously, a garment was developed using conductive thread-based sensors with the abil…
Ribosomal-processing cysteine protease homolog modulates <i>Streptococcus mutans</i> glucan production and interkingdom interactions Open
Glucan-dependent biofilm formation is a crucial process in the establishment of Streptococcus mutans as a cariogenic oral microbe. The process of glucan formation has been investigated in great detail, with glycosyltransferases GtfB, GtfC,…
View article: Mass spectrometry and split luciferase complementation assays reveal the MecA protein interactome of <i>Streptococcus mutans</i>
Mass spectrometry and split luciferase complementation assays reveal the MecA protein interactome of <i>Streptococcus mutans</i> Open
MecA is a highly conserved adaptor protein encoded by prokaryotes from the Bacillota phylum. MecA mutants exhibit similar pleiotropic defects in a variety of organisms, although most of these phenotypes currently lack a mechanistic basis. …
View article: Mass spectrometry and split luciferase complementation assays reveal the MecA protein interactome of<i>Streptococcus mutans</i>
Mass spectrometry and split luciferase complementation assays reveal the MecA protein interactome of<i>Streptococcus mutans</i> Open
MecA is a highly conserved adaptor protein encoded by prokaryotes from the Bacillota phylum. MecA mutants exhibit similar pleiotropic defects in a variety of organisms, although most of these phenotypes currently lack a mechanistic basis. …
IL-6 selectively suppresses cDC1 specification via C/EBPβ Open
Cytokines produced in association with tumors can impair antitumor immune responses by reducing the abundance of type 1 conventional dendritic cells (cDC1), but the mechanism remains unclear. Here, we show that tumor-derived IL-6 generally…
Enhanced in vitro type 1 conventional dendritic cell generation via the recruitment of hematopoietic stem cells and early progenitors by Kit ligand Open
In vitro culture of bone marrow (BM) with Fms‐like tyrosine kinase 3 ligand (Flt3L) is widely used to study development and function of type 1 conventional dendritic cells (cDC1). Hematopoietic stem cells (HSCs) and many progenitor populat…
Glycerol metabolism supports oral commensal interactions Open
During oral biofilm development, interspecies interactions drive species distribution and biofilm architecture. To understand what molecular mechanisms determine these interactions, we used information gained from recent biogeographical in…
<i>Cis</i>interactions in the<i>Irf8</i>locus regulate stage-dependent enhancer activation Open
Individual elements within a superenhancer can act in a cooperative or temporal manner, but the underlying mechanisms remain obscure. We recently identified an Irf8 superenhancer, within which different elements act at distinct stages of t…
View article: Development of the First Tractable Genetic System for Parvimonas micra, a Ubiquitous Pathobiont in Human Dysbiotic Disease
Development of the First Tractable Genetic System for Parvimonas micra, a Ubiquitous Pathobiont in Human Dysbiotic Disease Open
Parvimonas micra is among the most highly enriched species at numerous sites of mucosal dysbiotic disease and is closely associated with numerous cancers. Despite this, little is known about P. micra pathobiology, which is directly attribu…
View article: Development of the First Tractable Genetic System for <i>Parvimonas micra</i>, a Ubiquitous Pathobiont in Human Dysbiotic Disease
Development of the First Tractable Genetic System for <i>Parvimonas micra</i>, a Ubiquitous Pathobiont in Human Dysbiotic Disease Open
Parvimonas micra is a Gram-positive obligate anaerobe and a typical member of the human microbiome. P. micra is among the most highly enriched species at numerous sites of mucosal dysbiotic disease and is closely associated with the develo…
Transition from <i>cMyc</i> to <i>L-Myc</i> during dendritic cell development coordinated by rising levels of IRF8 Open
During dendritic cell (DC) development, Myc expression in progenitors is replaced by Mycl in mature DCs, but when and how this transition occurs is unknown. We evaluated DC development using reporters for MYC, MYCL, and cell cycle proteins…
View article: The transcription regulator BrsR serves as a network hub of natural competence protein–protein interactions in <i>Streptococcus mutans</i>
The transcription regulator BrsR serves as a network hub of natural competence protein–protein interactions in <i>Streptococcus mutans</i> Open
Significance Streptococcus mutans is one of the primary species associated with human dental caries, which affects the vast majority of adults worldwide. Like most streptococci, S. mutans is naturally competent and employs this ability to …
Post‐translational modification of <i>Streptococcus sanguinis</i> SpxB influences protein solubility and H <sub>2</sub> O <sub>2</sub> production Open
Streptococcal pyruvate oxidase (SpxB) is a hydrogen peroxide‐generating enzyme and plays a critical role in Streptococcus sanguinis interspecies interactions, but less is known about its biochemistry. We examined SpxB subcellular localizat…
The MYCL and MXD1 transcription factors regulate the fitness of murine dendritic cells Open
We previously found that MYCL is required by a Batf3 -dependent classical dendritic cell subset (cDC1) for optimal CD8 T cell priming, but the underlying mechanism has remained unclear. The MAX-binding proteins encompass a family of transc…
Development, Diversity, and Function of Dendritic Cells in Mouse and Human Open
The study of murine dendritic cell (DC) development has been integral to the identification of specialized DC subsets that have unique requirements for their form and function. Advances in the field have also provided a framework for the i…
Revisiting the specificity of the MHC class II transactivator CIITA in classical murine dendritic cells in vivo Open
Ciita was discovered for its role in regulating transcription of major histocompatibility complex class II (MHCII) genes. Subsequently, CIITA was predicted to control many other genes based on reporter and ChIP‐seq analysis but few such pr…
Deficiency of transcription factor RelB perturbs myeloid and DC development by hematopoietic-extrinsic mechanisms Open
Significance The transcription factor RelB has been thought to be required for dendritic cell (DC) development, although analysis of radiation bone marrow chimeras has raised some questions regarding this issue that have never been resolve…
RNA-Seq of the Caribbean reef-building coral <i>Orbicella faveolata</i> (Scleractinia-Merulinidae) under bleaching and disease stress expands models of coral innate immunity Open
Climate change-driven coral disease outbreaks have led to widespread declines in coral populations. Early work on coral genomics established that corals have a complex innate immune system, and whole-transcriptome gene expression studies h…