David B. Allison
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View article: Pair‐Feeding Study Designs Can Create Biases and Inflate Type I Error Rates: A Simulation Study
Pair‐Feeding Study Designs Can Create Biases and Inflate Type I Error Rates: A Simulation Study Open
Objective Pair‐feeding is a study design element where one group's food intake is provided to another group to assess whether a treatment effect is independent of food intake. Investigators often assume equivalent food intake across experi…
View article: Life-extending interventions do not necessarily result in compression of morbidity: a case example offering a robust statistical approach
Life-extending interventions do not necessarily result in compression of morbidity: a case example offering a robust statistical approach Open
Despite extensive research on life-extending interventions, rigorous statistical techniques to determine their impact on compression of morbidity (CoM) are rarely used. We present a case example of an analytical method for examining the ef…
View article: Concerns regarding the standard deviation of individual responses for assessing treatment response heterogeneity
Concerns regarding the standard deviation of individual responses for assessing treatment response heterogeneity Open
The estimation of treatment response heterogeneity (TRH) is increasingly important as medicine moves toward personalized approaches. Although various statistical methods have been proposed to quantify TRH in parallel-group trials, the stan…
View article: Commentary: Impact of resistance training intensity on body composition and nutritional intake among college women with overweight and obesity: a cluster randomized controlled trial
Commentary: Impact of resistance training intensity on body composition and nutritional intake among college women with overweight and obesity: a cluster randomized controlled trial Open
View article: Senolytic-Resistant Senescent Cells Have a Distinct SASP Profile and Functional Impact: The Path to Developing Senosensitizers
Senolytic-Resistant Senescent Cells Have a Distinct SASP Profile and Functional Impact: The Path to Developing Senosensitizers Open
The senescent cell (SC) fate is linked to aging, multiple disorders and diseases, and physical dysfunction. Senolytics, agents that selectively eliminate 30-70% of SCs, act by transiently disabling the senescent cell anti-apoptotic pathway…
View article: Associations among Human Milk Polyunsaturated Fatty Acids and Infant Sleep Patterns: A Cross-Sectional Study
Associations among Human Milk Polyunsaturated Fatty Acids and Infant Sleep Patterns: A Cross-Sectional Study Open
Higher HM proportions of omega-3 and omega-6, particularly ALA and LA, were associated with greater diurnal sleep in exclusively HM-fed 2 month olds. Further research is needed to explore underlying mechanisms and long-term developmental i…
View article: Food noise: definition, measurement, and future research directions
Food noise: definition, measurement, and future research directions Open
The term food noise has been recently popularized by individuals managing their weight or adhering to specific diets for health reasons. Anecdotal evidence from patients and clinical observations suggests that food noise involves constant …
View article: Adjusting for covariates representing potential confounders, mediators, or competing predictors in the presence of measurement error: Dispelling a potential misapprehension and insights for optimal study design with nutritional epidemiology examples
Adjusting for covariates representing potential confounders, mediators, or competing predictors in the presence of measurement error: Dispelling a potential misapprehension and insights for optimal study design with nutritional epidemiology examples Open
Background Variables such as dietary intake are measured with error yet frequently used in observational epidemiology. Although this limitation is sometimes noted, these variables are still often modeled as covariates without formal correc…
View article: Associations of Serum Omega-6 Polyunsaturated Fatty Acids with Biomarkers of Glucose Homeostasis
Associations of Serum Omega-6 Polyunsaturated Fatty Acids with Biomarkers of Glucose Homeostasis Open
View article: Associations of Serum Omega-6 Polyunsaturated Fatty Acids With Biomarkers of Inflammation
Associations of Serum Omega-6 Polyunsaturated Fatty Acids With Biomarkers of Inflammation Open
View article: Study Protocol for the Culturally Appropriate Recipes for Impactful Nutrition Goals for Communities Study (CARING for Communities)
Study Protocol for the Culturally Appropriate Recipes for Impactful Nutrition Goals for Communities Study (CARING for Communities) Open
View article: Fecal glucocorticoid metabolite and T3 profiles of orphaned elephants differ from non-orphaned elephants in Zambia
Fecal glucocorticoid metabolite and T3 profiles of orphaned elephants differ from non-orphaned elephants in Zambia Open
Background Elephants provide valuable insight into how early-life adverse events (ELAEs) associate with animal health and welfare because they can live to advanced ages, display extensive cognitive and memory capabilities, and rely heavily…
View article: 217 The impact of preoperative glucagon-like peptide-1 receptor agonists (GLP1) utilization on bariatric surgery outcomes
217 The impact of preoperative glucagon-like peptide-1 receptor agonists (GLP1) utilization on bariatric surgery outcomes Open
Objectives/Goals: Glucagon-like peptide-1 (GLP1) use prior to bariatric surgery may represent a novel approach to treating obesity. The objectives of this study were to describe trends in pre-bariatric GLP1 use, investigate social and clin…
View article: Improving Statistical Rigor in Animal Aging Research by Addressing Clustering and Nesting Effects: Illustration with the National Institute on Aging’s Intervention Testing Program Data
Improving Statistical Rigor in Animal Aging Research by Addressing Clustering and Nesting Effects: Illustration with the National Institute on Aging’s Intervention Testing Program Data Open
Clustering effects, such as those introduced by housing animals in shared cages, are often overlooked in preclinical lifespan studies, despite their potential to distort variance estimates and inflate Type I error rates, leading to mislead…
View article: The misalignment of incentives in academic publishing and implications for journal reform
The misalignment of incentives in academic publishing and implications for journal reform Open
For most researchers, academic publishing serves two goals that are often misaligned—knowledge dissemination and establishing scientific credentials. While both goals can encourage research with significant depth and scope, the latter can …
View article: A Framework for Assessing the Trustworthiness of Research Findings
A Framework for Assessing the Trustworthiness of Research Findings Open
Within the research community, the question “what makes research findings trustworthy?” will elicit different answers depending on the emphasis on research integrity and ethics, research methods, transparency, inclusion, assessment and pee…
View article: Evaluating the Reproducibility and Verifiability of Nutrition Research: A Case Study of Studies Assessing the Relationship Between Potatoes and Colorectal Cancer
Evaluating the Reproducibility and Verifiability of Nutrition Research: A Case Study of Studies Assessing the Relationship Between Potatoes and Colorectal Cancer Open
Background The credibility of nutritional research is dependent on the rigor with which studies are conducted and the ability for independent assessment to be performed. Despite the importance of these, more work is needed in the field of …
View article: A hematology-based clock derived from the Study of Longitudinal Aging in Mice to estimate biological age
A hematology-based clock derived from the Study of Longitudinal Aging in Mice to estimate biological age Open
View article: Catalyzing communities of research rigour champions
Catalyzing communities of research rigour champions Open
The biomedical sciences must maintain and enhance a research culture that prioritizes rigour and transparency. The US National Institute of Neurological Disorders and Stroke convened a workshop entitled 'Catalyzing Communities of Research …
View article: Hidden: A Baker’s Dozen Ways in Which Research Reporting is Less Transparent than it Could be and Suggestions for Implementing Einstein’s Dictum
Hidden: A Baker’s Dozen Ways in Which Research Reporting is Less Transparent than it Could be and Suggestions for Implementing Einstein’s Dictum Open
The tutelage of our mentors as scientists included the analogy that writing a good scientific paper was an exercise in storytelling that omitted unessential details that did not move the story forward or that detracted from the overall mes…
View article: Reproduction has immediate effects on female mortality, but no discernible lasting physiological impacts: A test of the disposable soma theory
Reproduction has immediate effects on female mortality, but no discernible lasting physiological impacts: A test of the disposable soma theory Open
The disposable soma theory (DST) posits that organisms age and die because of a direct trade-off in resource allocation between reproduction and somatic maintenance. DST predicts that investments in reproduction accentuate somatic damage w…
View article: Mapping epidermal and dermal cellular senescence in human skin aging
Mapping epidermal and dermal cellular senescence in human skin aging Open
Single‐cell RNA sequencing and spatial transcriptomics enable unprecedented insight into cellular and molecular pathways implicated in human skin aging and regeneration. Senescent cells are individual cells that are irreversibly cell cycle…
View article: On the pathogenesis of obesity: causal models and missing pieces of the puzzle
On the pathogenesis of obesity: causal models and missing pieces of the puzzle Open
View article: Adjusting for covariates representing potential confounders, mediators, or competing predictors in the presence of measurement error: Dispelling a potential misapprehension and insights for optimal study design with nutritional epidemiology examples
Adjusting for covariates representing potential confounders, mediators, or competing predictors in the presence of measurement error: Dispelling a potential misapprehension and insights for optimal study design with nutritional epidemiology examples Open
Background Variables such as dietary intake are measured with error yet frequently used in observational epidemiology. Although this limitation is sometimes noted, these variables are still often modeled as covariates without formal corre…
View article: Assessing the state of obesity care: Quality, access, guidelines, and standards
Assessing the state of obesity care: Quality, access, guidelines, and standards Open
Background An international panel of obesity medicine experts from multiple professional organizations examined patterns of obesity care and current obesity treatment guidelines to identify areas requiring updating in response to emerging …
View article: A Bayesian semi‐parametric scalar‐on‐function regression with measurement error using instrumental variables
A Bayesian semi‐parametric scalar‐on‐function regression with measurement error using instrumental variables Open
Wearable devices such as the ActiGraph are now commonly used in research to monitor or track physical activity. This trend corresponds with the growing need to assess the relationships between physical activity and health outcomes, such as…
View article: Guilt by association: Plant-based foods can be incorporated into both healthy and unhealthy plant-based diet indices associated with coronary heart disease
Guilt by association: Plant-based foods can be incorporated into both healthy and unhealthy plant-based diet indices associated with coronary heart disease Open
Background One approach to test for differential associations between plant foods with health uses a scoring approach: foods categorized into animal or ‘healthy’ plant-based or ‘unhealthy’ plant-based groups to construct a plant-based diet…
View article: Effectiveness of a Digital Weight Management Program on Diet Quality
Effectiveness of a Digital Weight Management Program on Diet Quality Open
View article: Benefits of calorie restriction in mice are mediated via energy imbalance, not absolute energy or protein intake
Benefits of calorie restriction in mice are mediated via energy imbalance, not absolute energy or protein intake Open
View article: Misstatements, misperceptions, and mistakes in controlling for covariates in observational research
Misstatements, misperceptions, and mistakes in controlling for covariates in observational research Open
We discuss 12 misperceptions, misstatements, or mistakes concerning the use of covariates in observational or nonrandomized research. Additionally, we offer advice to help investigators, editors, reviewers, and readers make more informed d…