David Arpon
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The Pandora’s box of novel technologies that may revolutionize lung cancer Open
Non-small cell lung cancer (NSCLC) is one of the most common cancers globally and has a 5-year survival rate ~20%. Immunotherapies have demonstrated long-term and durable responses in NSCLC patients, although they appear to be effective in…
View article: Considerations to Model Heart Disease in Women with Preeclampsia and Cardiovascular Disease
Considerations to Model Heart Disease in Women with Preeclampsia and Cardiovascular Disease Open
Preeclampsia is a multifactorial cardiovascular disorder diagnosed after 20 weeks of gestation, and is the leading cause of death for both mothers and babies in pregnancy. The pathophysiology remains poorly understood due to the variabilit…
View article: Considerations to Model Heart Disease in Women with Preeclampsia and Cardiovascular Disease
Considerations to Model Heart Disease in Women with Preeclampsia and Cardiovascular Disease Open
Preeclampsia is a multifactorial cardiovascular disorder diagnosed after 20 weeks of gestation that is the leading cause of death for both mothers and babies in pregnancy. The pathophysiology remains poorly understood due to variability an…
View article: Immune evasion via PD-1/PD-L1 on NK cells and monocyte/macrophages is more prominent in Hodgkin lymphoma than DLBCL
Immune evasion via PD-1/PD-L1 on NK cells and monocyte/macrophages is more prominent in Hodgkin lymphoma than DLBCL Open
Key Points Expansion of PD-1+ CD3−CD56hiCD16-ve NK cells and PD-L1+ monocytes/macrophages is more prominent in cHL than DLBCL. PD-1 blockade reverses the immune evasion mediated by the interaction of PD-1+ NK cells and PD-L1+ monocytes/mac…