Explanipedia

ETS1 suppresses Hepatic Stellate Cell activation and liver fibrosis Open

Wonseok Lee, Xiao Liu, Sara Brin Rosenthal, Charlene Miciano, Sadatsugu Sakane , et al. · 2025

Chronic liver injury results in activation of quiescent Hepatic Stellate Cells (qHSCs) into Collagen Type I-producing activated HSCs that make liver fibrotic. We identified ETS1/2 (E26 transformation-specific transcription factors 1/2) as …

Targeting serine dehydratase supports amino acid homeostasis and skin repair Open

Emeline Joulia, Ethan L. Ashley, Patrick Tseng, C. F. Aréchiga, Yuqiong Liang , et al. · 2025

Summary Serine and glycine are altered in patients with metabolic disorders, and this dysregulation can lead to diverse pathologies 1–6 . Modulation of serine levels via diet can influence relevant phenotypes in mouse models of metabolic s…

Immunogenicity of a trivalent haemorrhagic fever vaccine candidate against Sudan virus, Marburg virus and Lassa virus in an mpox vaccine Open

Martina Pfranger, Nina Krause, Benedikt Asbach, Johannes K. Meier, George Carnell , et al. · 2025

A multivalent vaccine targeting high-consequence infectious diseases in Sub-Saharan Africa (SSA), which are linked to high mortality, morbidity and overlapping clinical manifestations, would significantly improve health security and econom…

Peroxisome Proliferator–Activated Receptor Agonist IVA337 Alleviates Inflammation and Fibrosis in MASH by Restoring Lipid Homeostasis Open

Na Li, Shuai Wu, Xiaodan Li, Yan Meng, Yifu Ding , et al. · 2025

Author Correction: Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome Open

Hua Su, Fei Yang, Rao Fu, Brittney Trinh, Nina Sun , et al. · 2025

Immunopathogenic mechanisms and immunoregulatory therapies in MASLD Open

Yong He, Yingfen Chen, Shengying Qian, Van der Merwe, Debanjan Dhar , et al. · 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as nonalcoholic fatty liver disease (NAFLD), is the most prevalent chronic liver disease worldwide, with an estimated global prevalence of approximately 30%…

DHCR7 inhibition ameliorates MetALD and HCC in mice and human 3D liver spheroids Open

Gen Yamamoto, Raquel Carvalho‐Gontijo Weber, Wonseok Lee, Vivian Zhang, Haeum Jang , et al. · 2025

Population‐Based Versus Hospital‐Based Data in Amyotrophic Lateral Sclerosis—A Factor to Consider? Open

Johannes Dorst, Jens Dreyhaupt, Deborah Wernecke, Ulrike Weiland, Özlem Parlak , et al. · 2025

Background Over the past years, some studies in amyotrophic lateral sclerosis (ALS) have provided heterogeneous findings regarding demographic and clinical data as well as the impact of various prognostic factors. It is well known that the…

LARP6 regulates the mRNA translation of fibrogenic genes in liver fibrosis Open

Hyun Young Kim, Orel Mizrahi, Wonseok Lee, Sara Brin Rosenthal, Cuijuan Han , et al. · 2025

Summary Metabolic syndrome and excessive alcohol consumption result in liver injury and fibrosis, which is characterized by increased collagen production by activated Hepatic Stellate Cells (HSCs). LARP6, an RNA-binding protein, was shown …

Induction of MASH in three-dimensional bioprinted human liver tissue Open

Viral Joshi, Dwayne Carter, Alice E. Chen, Keith E. Murphy, J. William Higgins , et al. · 2024

Metabolic dysfunction-associated steatohepatitis (MASH), formerly known as nonalcoholic steatohepatitis (MASH), is a major risk factor for cirrhosis and hepatocellular carcinoma (HCC) and a leading cause of liver transplantation. MASH is c…

Featured Cover Open

Anandini Suri, Zidong Zhang, Brent A. Neuschwander‐Tetri, David A. Lomas, Nina Heyer‐Chauhan , et al. · 2024

Multi-modal analysis of human hepatic stellate cells identifies novel therapeutic targets for metabolic dysfunction-associated steatotic liver disease Open

Hyun Young Kim, Sara Brin Rosenthal, Xiao Liu, Charlene Miciano, Xiaomeng Hou , et al. · 2024

Serum amyloid P (PTX2) attenuates hepatic fibrosis in mice by inhibiting the activation of fibrocytes and HSCs Open

Min Cong, Raquel Weber, Sadatsugu Sakane, Vivian Zhang, Chunyan Jiang , et al. · 2024

Background: Liver fibrosis is caused by chronic toxic or cholestatic liver injury. Fibrosis results from the recruitment of myeloid cells into the injured liver, the release of inflammatory and fibrogenic cytokines, and the activation of m…

Fibrosis, biomarkers and liver biopsy in <span>AAT</span> deficiency and relation to liver Z protein polymer accumulation Open

Anandini Suri, Zidong Zhang, Brent A. Neuschwander‐Tetri, David A. Lomas, Nina Heyer‐Chauhan , et al. · 2024

Background and Aims The course of adults with ZZ alpha‐1‐antitrypsin deficiency (AATD) liver disease is unpredictable. The utility of markers, including liver biopsy, is undefined. Methods A prospective cohort, including protocol liver bio…

Lipid-associated macrophages’ promotion of fibrosis resolution during MASH regression requires TREM2 Open

Souradipta Ganguly, Sara Brin Rosenthal, Kei Ishizuka, Ty D. Troutman, Theresa V. Rohm , et al. · 2024

While macrophage heterogeneity during metabolic dysfunction-associated steatohepatitis (MASH) has been described, the fate of these macrophages during MASH regression is poorly understood. Comparing macrophage heterogeneity during MASH pro…

Protocol to generate human liver spheroids to study liver fibrosis induced by metabolic stress Open

Hyun Young Kim, Wonseok Lee, Xiao Liu, Haeum Jang, Sadatsugu Sakane , et al. · 2024

Currently, there is no effective treatment for obesity and alcohol-associated liver diseases, partially due to the lack of translational human models. Here, we present a protocol to generate 3D human liver spheroids that contain all the li…

Alcohol-Associated Liver Disease Outcomes: Critical Mechanisms of Liver Injury Progression Open

Natalia A. Osna, Irina Tikhanovich, Martí Ortega‐Ribera, Sebastian Mueller, Chaowen Zheng , et al. · 2024

Alcohol-associated liver disease (ALD) is a substantial cause of morbidity and mortality worldwide and represents a spectrum of liver injury beginning with hepatic steatosis (fatty liver) progressing to inflammation and culminating in cirr…

Technical and Religious Perspectives on AI Misinformation and Disinformation Open

David A. Brenner, Yaqub Chaudhary, Robert M. Geraci, Mark Graves, Haley Griese , et al. · 2024

Effects of tofersen treatment on neurofilament levels in SOD1-amyotrophic lateral sclerosis - two years of experience in a "real-world” cohort Open

Manuel Wiesenfarth, Zeynep Elmas, Özlem Parlak, Željko Uzelac, V. Teumer , et al. · 2024

Role of Hepatic Stellate and Liver Sinusoidal Endothelial Cells in a Human Primary Cell Three-Dimensional Model of Nonalcoholic Steatohepatitis Open

Philip K. Tan, Traci M. Ostertag, Sara Brin Rosenthal, Daisy Chilin-Fuentes, Haylee Aidnik , et al. · 2023

SREBP Regulation of Lipid Metabolism in Liver Disease, and Therapeutic Strategies Open

Na Li, Xiaodan Li, Yifu Ding, Xiao Liu, Karin Diggle , et al. · 2023

Sterol regulatory element-binding proteins (SREBPs) are master transcription factors that play a crucial role in regulating genes involved in the biogenesis of cholesterol, fatty acids, and triglycerides. As such, they are implicated in se…

SREBP Regulation of Lipid Metabolism in Liver Disease, and Therapeutic Strategies Open

Na Li, Xiaodan Li, Yifu Ding, Xiao Liu, Karin Diggle , et al. · 2023

Sterol regulatory element-binding proteins (SREBPs) are transcription factors that regulate genes involved in the biogenesis of cholesterol, fatty acids, and triglycerides. SREBPs are involved in the pathogenesis of non-alcoholic fatty liv…

The Origin and Fate of Liver Myofibroblasts Open

Hyun Young Kim, Sadatsugu Sakane, Álvaro Eguileor, Raquel Weber, Wonseok Lee , et al. · 2023

Liver fibrosis of different etiologies is a serious health problem worldwide. There is no effective therapy available for liver fibrosis except the removal of the underlying cause of injury or liver transplantation. Development of liver fi…

Isolation of primary human liver cells from normal and nonalcoholic steatohepatitis livers Open

Xiao Liu, Kevin Lam, Huayi Zhao, Sadatsugu Sakane, Hyun Young Kim , et al. · 2023

Here, we present a protocol for isolating human hepatocytes and neural progenitor cells from normal and nonalcoholic steatohepatitis livers. We describe steps for perfusion for scaled-up liver cell isolation and optimization of chemical di…

Publisher Correction: Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome Open

Hua Su, Fei Yang, Rao Fu, Brittney Trinh, Nina Sun , et al. · 2023

Candida albicans-specific Th17 cell-mediated response contributes to alcohol-associated liver disease Open

Su-Ling Zeng, Elisa Rosati, Carina Saggau, Berith Messner, Huikuan Chu , et al. · 2023

The Role of Mesothelin in Activation of Portal Fibroblasts in Cholestatic Liver Injury Open

Takahiro Nishio, Yukinori Koyama, Hiroaki Fuji, Kei Ishizuka, Keiko Iwaisako , et al. · 2022

Fibrosis is a common consequence of abnormal wound healing, which is characterized by infiltration of myofibroblasts and formation of fibrous scar. In liver fibrosis, activated Hepatic Stellate Cells (aHSCs) and activated Portal Fibroblast…

Developing a<span>highly‐reliable</span>learning health system Open

Robert El‐Kareh, David A. Brenner, Chris Longhurst · 2022

Multiple independent frameworks to support continuous improvement have been proposed to guide healthcare organizations. Two of the most visible are High‐reliability Health care, (Chassin et al., 2013) which is emphasized by The Joint Commi…

Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome Open

Hua Su, Fei Yang, Rao Fu, Brittney Trinh, Nina Sun , et al. · 2022

Multiplex short tandem repeat profiling of immortalized hepatic stellate cell line Col-GFP HSC Open

Steffen K. Meurer, David A. Brenner, Ralf Weiskirchen · 2022

Misidentification, cross-contamination and genetic drift of continuous animal cell lines are persistent problems in biomedical research, leading to erroneous results and inconsistent or invalidated studies. The establishment of immortalize…

David A. Brenner YOU? Author Swipe