David B. Chou
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View article: Endothelial CLK2 as a therapeutic target for acute radiation syndrome
Endothelial CLK2 as a therapeutic target for acute radiation syndrome Open
Damage to the vascular endothelium is a major contributor to acute radiation injury in multiple organs that underlies acute radiation syndrome (ARS), yet there are no FDA-approved radiation countermeasures targeting endothelial cells. Use …
View article: Induction of cervical dysfunction associated with preterm birth by IL-1 and dysbiotic microbiome revealed in human endocervix chips
Induction of cervical dysfunction associated with preterm birth by IL-1 and dysbiotic microbiome revealed in human endocervix chips Open
Cervical dysfunction, a major contributor to preterm labor and neonatal mortality, remains poorly understood due to the absence of physiologically relevant human models. Here, we show that a microfluidic human Endocervix Chip lined by prim…
View article: Human Organ Chips Reveal New Inflammatory Bowel Disease Drivers
Human Organ Chips Reveal New Inflammatory Bowel Disease Drivers Open
View article: Human Organ Chips Reveal New Inflammatory Bowel Disease Drivers
Human Organ Chips Reveal New Inflammatory Bowel Disease Drivers Open
Inflammatory bowel disease (IBD) patients exhibit compromised intestinal barrier function and decreased mucus accumulation, as well as increased inflammation, fibrosis, and cancer risk, with symptoms often being exacerbated in women during…
View article: Supplementary Data from Inflammatory and MicroRNA Gene Expression as Prognostic Classifier of Barrett's-Associated Esophageal Adenocarcinoma
Supplementary Data from Inflammatory and MicroRNA Gene Expression as Prognostic Classifier of Barrett's-Associated Esophageal Adenocarcinoma Open
Supplementary Figures S1-S2 and Supplementary Tables S1-S4.
View article: Data from Inflammatory and MicroRNA Gene Expression as Prognostic Classifier of Barrett's-Associated Esophageal Adenocarcinoma
Data from Inflammatory and MicroRNA Gene Expression as Prognostic Classifier of Barrett's-Associated Esophageal Adenocarcinoma Open
Purpose: Esophageal cancer is one of the most aggressive and deadly forms of cancer; highlighting the need to identify biomarkers for early detection and prognostic classification. Our recent studies have identified inflammatory gen…
View article: Data from Inflammatory and MicroRNA Gene Expression as Prognostic Classifier of Barrett's-Associated Esophageal Adenocarcinoma
Data from Inflammatory and MicroRNA Gene Expression as Prognostic Classifier of Barrett's-Associated Esophageal Adenocarcinoma Open
Purpose: Esophageal cancer is one of the most aggressive and deadly forms of cancer; highlighting the need to identify biomarkers for early detection and prognostic classification. Our recent studies have identified inflammatory gen…
View article: Supplementary Data from Inflammatory and MicroRNA Gene Expression as Prognostic Classifier of Barrett's-Associated Esophageal Adenocarcinoma
Supplementary Data from Inflammatory and MicroRNA Gene Expression as Prognostic Classifier of Barrett's-Associated Esophageal Adenocarcinoma Open
Supplementary Figures S1-S2 and Supplementary Tables S1-S4.
View article: Differential ABC transporter expression during hematopoiesis contributes to neutrophil-biased toxicity of Aurora kinase inhibitors
Differential ABC transporter expression during hematopoiesis contributes to neutrophil-biased toxicity of Aurora kinase inhibitors Open
Drug-induced cytopenias are a prevalent and significant issue that worsens clinical outcomes and hinders the effective treatment of cancer. While reductions in blood cell numbers are classically associated with traditional cytotoxic chemot…
View article: Author Correction: On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology
Author Correction: On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology Open
View article: On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology
On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology Open
View article: Robotic fluidic coupling and interrogation of multiple vascularized organ chips
Robotic fluidic coupling and interrogation of multiple vascularized organ chips Open
View article: Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips
Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips Open
View article: Engineered E. coli Nissle 1917 for the delivery of matrix-tethered therapeutic domains to the gut
Engineered E. coli Nissle 1917 for the delivery of matrix-tethered therapeutic domains to the gut Open
View article: Human Colon-on-a-Chip Enables Continuous In Vitro Analysis of Colon Mucus Layer Accumulation and Physiology
Human Colon-on-a-Chip Enables Continuous In Vitro Analysis of Colon Mucus Layer Accumulation and Physiology Open
View article: Human colon-on-a-chip enables continuous <i>in vitro</i> analysis of colon mucus layer accumulation and physiology
Human colon-on-a-chip enables continuous <i>in vitro</i> analysis of colon mucus layer accumulation and physiology Open
Background & Aims The mucus layer in the human colon protects against commensal bacteria and pathogens, and defects in its unique bilayered structure contribute to intestinal disorders, such as ulcerative colitis. However, our understandin…
View article: Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites
Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites Open
View article: A robotic platform for fluidically-linked human body-on-chips experimentation
A robotic platform for fluidically-linked human body-on-chips experimentation Open
Here we describe of an ‘Interrogator’ instrument that uses liquid-handling robotics, a custom software package, and an integrated mobile microscope to enable automated culture, perfusion, medium addition, fluidic linking, sample collection…
View article: Species-specific enhancement of enterohemorrhagic <i>E. Coli</i> pathogenesis mediated by microbiome metabolites
Species-specific enhancement of enterohemorrhagic <i>E. Coli</i> pathogenesis mediated by microbiome metabolites Open
Background Species-specific differences in tolerance to infection are exemplified by the high susceptibility of humans to enterohemorrhagic E. coli (EHEC) infection whereas mice are relatively resistant to this pathogen. This intrinsic spe…
View article: Additional file 9: of Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites
Additional file 9: of Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites Open
Table S2. List of 30 known metabolites enriched in Hmm compared to Mmm that were selected for fliC-luciferase screening (CAS n: Chemical Abstracts Service number; “name”: metabolites with a known name; “similarity”: closest MSMS spectrum i…
View article: Additional file 5: of Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites
Additional file 5: of Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites Open
Table S1. Transcriptomics analysis of long polar fimbriae genes.. (XLSX 8â kb)
View article: Additional file 15: of Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites
Additional file 15: of Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites Open
Table S3. Reagents and resources. (XLSX 16â kb)
View article: Additional file 16: of Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites
Additional file 16: of Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites Open
Table S4. 16â s rRNA gene data. (CSV 291â kb)
View article: Probiotic Associated Therapeutic Curli Hybrids (PATCH)
Probiotic Associated Therapeutic Curli Hybrids (PATCH) Open
There is an unmet need for new treatment methods for inflammatory bowel disease (IBD) that can reliably maintain remission without leading to detrimental side effects. Beneficial bacteria have been utilized as an alternative treatment for …
View article: Human bone marrow disorders recapitulated in vitro using organ chip technology
Human bone marrow disorders recapitulated in vitro using organ chip technology Open
Understanding human bone marrow (BM) pathophysiology in the context of myelotoxic stress induced by drugs, radiation, or genetic mutations is of critical importance in clinical medicine. However, study of these dynamic cellular responses i…
View article: EBV-negative monomorphic B-cell post-transplant lymphoproliferative disorders are pathologically distinct from EBV-positive cases and frequently contain TP53 mutations
EBV-negative monomorphic B-cell post-transplant lymphoproliferative disorders are pathologically distinct from EBV-positive cases and frequently contain TP53 mutations Open