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View article: Perioperative Management of a Patient With Very Long Chain Acyl-CoA Dehydrogenase Deficiency Undergoing Laparoscopic Sleeve Gastrectomy: First Report of Bariatric Surgery in VLCADD
Perioperative Management of a Patient With Very Long Chain Acyl-CoA Dehydrogenase Deficiency Undergoing Laparoscopic Sleeve Gastrectomy: First Report of Bariatric Surgery in VLCADD Open
Very Long Chain Acyl-CoA Dehydrogenase Deficiency (VLCADD) is a rare inherited disorder of mitochondrial fatty acid β-oxidation that predisposes patients to metabolic crises, rhabdomyolysis, and cardiomyopathy. Surgical stress, fasting, an…
View article: Mechanically powered negative pressure dressing reduces surgical site infection after stoma reversal
Mechanically powered negative pressure dressing reduces surgical site infection after stoma reversal Open
Intestinal stoma reversal wounds closed primarily and dressed with the MP-NPD dressings had very low stoma site SSI rates. These results are promising as they pertain to the use of MP-NPD in stoma reversal procedures, however further large…
View article: An overview of systematic reviews investigating clinical features for diagnosing neck pain and its associated disorders
An overview of systematic reviews investigating clinical features for diagnosing neck pain and its associated disorders Open
This review found limited indicators providing strong diagnostic utility for diagnosing neck pain. Strength of recommendations are limited by heterogeneous outcomes, methodology, and classification systems. Future research should investiga…
View article: Multi-Agent Vulcan: An Information-Driven Multi-Agent Path Finding Approach
Multi-Agent Vulcan: An Information-Driven Multi-Agent Path Finding Approach Open
Scientists often search for phenomena of interest while exploring new environments. Autonomous vehicles are deployed to explore such areas where human-operated vehicles would be costly or dangerous. Online control of autonomous vehicles fo…
View article: Correlates of improved outcomes in patients with COVID-19 treated in US emergency departments
Correlates of improved outcomes in patients with COVID-19 treated in US emergency departments Open
Operational and clinical outcomes of ED-based treatment of individuals with COVID-19 improved in the first two years of the pandemic. This improvement is likely multifactorial and includes the development and deployment of SARS-CoV-2-speci…
View article: Childhood adversity and mental health admission patterns prior to young person suicide (CHASE): a case-control 36 year linked hospital data study, Scotland UK 1981–2017
Childhood adversity and mental health admission patterns prior to young person suicide (CHASE): a case-control 36 year linked hospital data study, Scotland UK 1981–2017 Open
Background Childhood adversity is associated with increased later mental health problems and suicidal behaviour. Opportunities for earlier healthcare identification and intervention are needed. Aim To determine associations between hospita…
View article: Task-driven Risk-bounded Hierarchical Reinforcement Learning Based on Iterative Refinement
Task-driven Risk-bounded Hierarchical Reinforcement Learning Based on Iterative Refinement Open
Deep Reinforcement Learning (DRL) has garnered substantial acclaim for its versatility and widespread applications across diverse domains. Aligned with human-like learning, DRL is grounded in the fundamental principle of learning from inte…
View article: Use of a Self-Contained Mechanically Powered Negative Pressure Dressing Reduces Surgical Site Infection After Intestinal Stoma Reversal
Use of a Self-Contained Mechanically Powered Negative Pressure Dressing Reduces Surgical Site Infection After Intestinal Stoma Reversal Open
Background The use of closed-incision negative pressure wound therapy (ci-NPWT) has been shown to reduce postoperative wound complications and surgical site infections after stoma closures. However, use of this approach has not been widely…
View article: Factors associated with chronic depressive symptoms across adolescence and young adulthood: a UK birth cohort study
Factors associated with chronic depressive symptoms across adolescence and young adulthood: a UK birth cohort study Open
Aims Identifying children and/or adolescents who are at highest risk for developing chronic depression is of utmost importance, so that we can develop more effective and targeted interventions to attenuate the risk trajectory of depression…
View article: Understanding capacity for implementing new interventions: A qualitative study of speech and language therapy services for children with speech sound disorder*
Understanding capacity for implementing new interventions: A qualitative study of speech and language therapy services for children with speech sound disorder* Open
Background Many speech sound disorder (SSD) interventions with a long‐term evidence base are ‘new’ to clinical practice, and the role of services in supporting or constraining capacity for practice change is underexplored. Innovations from…
View article: Development of a narrative and image-based intervention delivered by text message to support smoking cessation in pregnant women (Preprint)
Development of a narrative and image-based intervention delivered by text message to support smoking cessation in pregnant women (Preprint) Open
BACKGROUND This paper describes the development process of the ‘SKIP IT’ text messaging intervention to promote smoking cessation during pregnancy. Smoking during pregnancy is a major risk to mother and infant health. Pregnant women who s…
View article: Hemopericardium in chronic kidney disease: An uncommon manifestation of pericarditis with a bloody pericardial effusion
Hemopericardium in chronic kidney disease: An uncommon manifestation of pericarditis with a bloody pericardial effusion Open
Patients with end-stage renal disease are at increased risk for the development of uremic pericarditis or dialysis-associated pericarditis, and either comorbidity can be complicated by pericardial effusion. Patients with end-stage renal di…
View article: Improving antibiotic use in hospitals: development of a digital antibiotic review tracking toolkit (DARTT) using the behaviour change wheel
Improving antibiotic use in hospitals: development of a digital antibiotic review tracking toolkit (DARTT) using the behaviour change wheel Open
This novel work demonstrates how the Behaviour Change Wheel can be used with the Medical Research Council framework to develop a theory-based behaviour change intervention targeting barriers to timely hospital antibiotic reassessment. Futu…
View article: Dose-response effects of selective serotonin reuptake inhibitor monotherapy for the treatment of depression: systematic review of reviews and meta-narrative synthesis
Dose-response effects of selective serotonin reuptake inhibitor monotherapy for the treatment of depression: systematic review of reviews and meta-narrative synthesis Open
Objective To assess and clarify the relations between selective serotonin reuptake inhibitor (SSRI) dose efficacy, acceptability (early treatment discontinuation (dropouts)), and tolerability (reported adverse drug effects), and critically…
View article: The first 20 months of the COVID-19 pandemic: Mortality, intubation and ICU rates among 104,590 patients hospitalized at 21 United States health systems
The first 20 months of the COVID-19 pandemic: Mortality, intubation and ICU rates among 104,590 patients hospitalized at 21 United States health systems Open
Main objective There is limited information on how patient outcomes have changed during the COVID-19 pandemic. This study characterizes changes in mortality, intubation, and ICU admission rates during the first 20 months of the pandemic. S…
View article: Childhood adversity, mental health and suicide (CHASE): a longitudinal case-control linked data study of lifetime inpatient records associated with suicide.
Childhood adversity, mental health and suicide (CHASE): a longitudinal case-control linked data study of lifetime inpatient records associated with suicide. Open
ObjectivesChildhood adversity (CA) carries an increased risk of developing later mental health (MH) problems and suicidal behaviour. This study aimed to summarise lifetime hospital attendances for CA and MH in young people who later died b…
View article: Reducing patient delay in acute coronary syndrome: Randomized controlled trial testing effect of behaviour change intervention on intentions to seek help
Reducing patient delay in acute coronary syndrome: Randomized controlled trial testing effect of behaviour change intervention on intentions to seek help Open
Objectives The aim of this study was to evaluate the efficacy of a behaviour change intervention to reduce patient delay with symptoms of acute coronary syndrome. Design A 3‐arm web‐based, parallel randomized controlled trial. Methods The …
View article: A behavioural intervention to increase lay-people's intentions to initiate CPR in the event of Out-of-Hospital Cardiac Arrest: results from BICeP pilot trial
A behavioural intervention to increase lay-people's intentions to initiate CPR in the event of Out-of-Hospital Cardiac Arrest: results from BICeP pilot trial Open
Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Medical Research Council Background Cardiopulmonary resuscitation (CPR) is the single most important factor determining survi…
View article: A Bucket Elimination Approach for Determining Strong Controllability of Temporal Plans with Uncontrollable Choices
A Bucket Elimination Approach for Determining Strong Controllability of Temporal Plans with Uncontrollable Choices Open
This work presents a new algorithm based on the Bucket Elimination framework that efficiently determines strong controllability of temporal plans formulated as Labeled Simple Temporal Networks with Uncertainty (LSTNU) with controllable and…
View article: The psychological and behavioural factors associated with laypeople initiating CPR for out-of-hospital cardiac arrest: a systematic review
The psychological and behavioural factors associated with laypeople initiating CPR for out-of-hospital cardiac arrest: a systematic review Open
Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Chief Scientist Office, Scottish Government OnBehalf BICeP Study Group Background Prompt, effective CPR greatly increases the…
View article: Developing a behavioural intervention to increase lay-people"s intentions to initiate CPR in the event of Out-of-Hospital Cardiac Arrest (OHCA)
Developing a behavioural intervention to increase lay-people"s intentions to initiate CPR in the event of Out-of-Hospital Cardiac Arrest (OHCA) Open
Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Medical Research Council OnBehalf BICeP Study Group Background Prompt, effective bystander cardiopulmonary resuscitation (CPR…