David B. Kurland
YOU?
Author Swipe
View article: A Multi-AI Agent Framework for Interactive Neurosurgical Education and Evaluation: From Vignettes to Virtual Conversations
A Multi-AI Agent Framework for Interactive Neurosurgical Education and Evaluation: From Vignettes to Virtual Conversations Open
Background and Objectives Traditional medical board examinations present clinical information in static vignettes with multiple-choices, fundamentally different from how physicians gather and integrate data in practice. Recent advances in …
View article: AO Spine Knowledge Forums Promote Collaboration and Elevate the Impact of Research: A Bibliometric Analysis
AO Spine Knowledge Forums Promote Collaboration and Elevate the Impact of Research: A Bibliometric Analysis Open
Study Design Bibliometric analysis. Objectives This study used bibliometric analyses to characterize the effect of AO Spine Knowledge Forum (KF) participation on publication trends among members. We examined associations of membership in K…
View article: The Bibliometric Evolution of Neurosurgery Publications From 1977 to 2023
The Bibliometric Evolution of Neurosurgery Publications From 1977 to 2023 Open
BACKGROUND AND OBJECTIVES: Neurosurgery is a world leader in disseminating neurosurgical science. Although the literature has seen significant increases in academic collaboration, data science, and authorship diversity, the bibliometric ev…
View article: RETRACTED: Repurposing the Scientific Literature with Vision-Language Models
RETRACTED: Repurposing the Scientific Literature with Vision-Language Models Open
The authors have requested that this preprint be removed from Research Square.
View article: Medical large language models are vulnerable to data-poisoning attacks
Medical large language models are vulnerable to data-poisoning attacks Open
The adoption of large language models (LLMs) in healthcare demands a careful analysis of their potential to spread false medical knowledge. Because LLMs ingest massive volumes of data from the open Internet during training, they are potent…
View article: Disparities in neurosurgical care: Using length of stay to evaluate efficiency of care in New York City hospitals
Disparities in neurosurgical care: Using length of stay to evaluate efficiency of care in New York City hospitals Open
Objective: We sought to analyze public and private hospital patient cohorts in New York City (NYC) to assess differences in hospital access and outcomes from 2009-2022.Methods: Inpatient neurosurgical discharges, as determined by APR-DRG c…
View article: The Evolution of Skull Base Surgery: A Bibliometric Analysis Spanning Nearly 125 Years
The Evolution of Skull Base Surgery: A Bibliometric Analysis Spanning Nearly 125 Years Open
Introduction Skull base surgery has evolved from fundamental elements into a distinct multidisciplinary specialty. Using bibliometrics, we appraised the literature pertaining to skull base surgery since 1900 and studied the emergence of th…
View article: The Evolution of Pediatric Spine Surgery: A Bibliometric Analysis of Publications From 1902 to 2023
The Evolution of Pediatric Spine Surgery: A Bibliometric Analysis of Publications From 1902 to 2023 Open
BACKGROUND AND OBJECTIVES: Pediatric spine surgery has evolved considerably over the past century. No previous study conducted a bibliometric analysis of the corpus of pediatric spine surgery. We used big data and advanced bibliometric ana…
View article: Health system-scale language models are all-purpose prediction engines
Health system-scale language models are all-purpose prediction engines Open
Physicians make critical time-constrained decisions every day. Clinical predictive models can help physicians and administrators make decisions by forecasting clinical and operational events. Existing structured data-based clinical predict…
View article: Surgical management of Hirayama disease in a pediatric patient presenting with severe cervical kyphosis and focal myelopathy: illustrative case
Surgical management of Hirayama disease in a pediatric patient presenting with severe cervical kyphosis and focal myelopathy: illustrative case Open
BACKGROUND Hirayama disease (HD) is a rare, nonfamilial neuromuscular disease causing cervical myelopathy and deformity, most commonly effecting pubertal Asian males. Patients whose nonoperative treatment fails and who cannot tolerate long…
View article: Language Model Classifier Aligns Better with Physician Word Sensitivity than XGBoost on Readmission Prediction
Language Model Classifier Aligns Better with Physician Word Sensitivity than XGBoost on Readmission Prediction Open
Traditional evaluation metrics for classification in natural language processing such as accuracy and area under the curve fail to differentiate between models with different predictive behaviors despite their similar performance metrics. …
View article: Pial brainstem artery arteriovenous malformation with flow-related intracanalicular aneurysm masquerading as vestibular schwannoma: illustrative case
Pial brainstem artery arteriovenous malformation with flow-related intracanalicular aneurysm masquerading as vestibular schwannoma: illustrative case Open
BACKGROUND Lesions of the internal auditory canal presenting with partial hearing loss are almost always vestibular schwannomas (VSs). Intracanalicular anterior inferior cerebellar artery (AICA) aneurysms are extremely rare but can mimic V…
View article: The Cost Effectiveness of Implementation of a Postoperative Endocrinopathy Management Protocol after Resection of Pituitary Adenomas
The Cost Effectiveness of Implementation of a Postoperative Endocrinopathy Management Protocol after Resection of Pituitary Adenomas Open
Purpose After developing a protocol for evaluating, diagnosing, and treating postoperative endocrinopathy both during the hospitalization and during the immediate discharge period following resection of pituitary adenomas, we sought to ass…
View article: Management and surgical outcomes of dystrophic scoliosis in neurofibromatosis type 1: a systematic review
Management and surgical outcomes of dystrophic scoliosis in neurofibromatosis type 1: a systematic review Open
OBJECTIVE Neurofibromatosis type 1 (NF1) dystrophic scoliosis is an early-onset, rapidly progressive multiplanar deformity. There are few studies on the surgical management of this patient population. Specifically, perioperative morbidity,…
View article: Exploring DNA Methylation for Prognosis and Analyzing the Tumor Microenvironment in Pleomorphic Xanthoastrocytoma
Exploring DNA Methylation for Prognosis and Analyzing the Tumor Microenvironment in Pleomorphic Xanthoastrocytoma Open
Pleomorphic xanthoastrocytoma (PXA) is a rare type of brain tumor that affects children and young adults. Molecular prognostic markers of PXAs remain poorly established. Similar to gangliogliomas, PXAs show prominent immune cell infiltrate…
View article: PATH-40. PROFILING PLEOMORPHIC XANTHROASTROCYTOMA WITH DNA METHYLATION AND EXPLORING THE TUMOR IMMUNE CELL-TYPE COMPOSITION WITH METHYLATION-BASED DECONVOLUTION
PATH-40. PROFILING PLEOMORPHIC XANTHROASTROCYTOMA WITH DNA METHYLATION AND EXPLORING THE TUMOR IMMUNE CELL-TYPE COMPOSITION WITH METHYLATION-BASED DECONVOLUTION Open
INTRODUCTION Pleomorphic xanthoastrocytoma (PXA) is a rare type of brain tumor that commonly affects children and young adults. PXAs are typically characterized by tumor lymphocytic infiltration, but the significance of the tumor immune mi…
View article: Human Disease Ontology 2018 update: classification, content and workflow expansion
Human Disease Ontology 2018 update: classification, content and workflow expansion Open
The Human Disease Ontology (DO) (http://www.disease-ontology.org), database has undergone significant expansion in the past three years. The DO disease classification includes specific formal semantic rules to express meaningful disease mo…
View article: IQOs : Forskning och utvecklings påverkan på underprissättning och långsiktig prestation hos svenska IPOs
IQOs : Forskning och utvecklings påverkan på underprissättning och långsiktig prestation hos svenska IPOs Open
Denna studie undersöker hur balanserade utgifter för utvecklingsarbeten påverkar underprissättning och långsiktig prestation hos svenska IPOs mellan åren 2007-2014. Två regressionsmodeller används för att undersöka sambandet mellan underpr…
View article: The Sur1-Trpm4 channel regulates NOS2 transcription in TLR4-activated microglia
The Sur1-Trpm4 channel regulates NOS2 transcription in TLR4-activated microglia Open
Sur1-Trpm4 constitutes a novel mechanism by which TLR4-activated microglia regulate pro-inflammatory, Ca(2+)-sensitive gene expression, including Nos2.
View article: Inducible nitric oxide synthase (NOS-2) in subarachnoid hemorrhage: Regulatory mechanisms and therapeutic implications
Inducible nitric oxide synthase (NOS-2) in subarachnoid hemorrhage: Regulatory mechanisms and therapeutic implications Open
Aneurysmal subarachnoid hemorrhage (SAH) typically carries a poor prognosis. Growing evidence indicates that overabundant production of nitric oxide (NO) may be responsible for a large part of the secondary injury that follows SAH. Althoug…
View article: Methemoglobin Is an Endogenous Toll-Like Receptor 4 Ligand—Relevance to Subarachnoid Hemorrhage
Methemoglobin Is an Endogenous Toll-Like Receptor 4 Ligand—Relevance to Subarachnoid Hemorrhage Open
Neuroinflammation is a well-recognized consequence of subarachnoid hemorrhage (SAH), and may be responsible for important complications of SAH. Signaling by Toll-like receptor 4 (TLR4)-mediated nuclear factor κB (NFκB) in microglia plays a…
View article: Glibenclamide for the Treatment of Ischemic and Hemorrhagic Stroke
Glibenclamide for the Treatment of Ischemic and Hemorrhagic Stroke Open
Ischemic and hemorrhagic strokes are associated with severe functional disability and high mortality. Except for recombinant tissue plasminogen activator, therapies targeting the underlying pathophysiology of central nervous system (CNS) i…