David Baillat
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View article: Self-oligomerization regulates stability of survival motor neuron protein isoforms by sequestering an SCFSlmb degron
Self-oligomerization regulates stability of survival motor neuron protein isoforms by sequestering an SCFSlmb degron Open
Spinal muscular atrophy (SMA) is caused by homozygous mutations in human SMN1 Expression of a duplicate gene (SMN2) primarily results in skipping of exon 7 and production of an unstable protein isoform, SMNΔ7. Although SMN2 exon skipping i…
Composition of the Survival Motor Neuron (SMN) Complex in <i>Drosophila melanogaster</i> Open
Spinal Muscular Atrophy (SMA) is caused by homozygous mutations in the human survival motor neuron 1 (SMN1) gene. SMN protein has a well-characterized role in the biogenesis of small nuclear ribonucleoproteins (snRNPs), core components of …
View article: Composition of the Survival Motor Neuron (SMN) complex in <i>Drosophila melanogaster</i>
Composition of the Survival Motor Neuron (SMN) complex in <i>Drosophila melanogaster</i> Open
Spinal Muscular Atrophy (SMA) is caused by homozygous mutations in the human survival motor neuron 1 ( SMN1 ) gene. SMN protein has a well-characterized role in the biogenesis of small nuclear ribonucleoproteins (snRNPs), core components o…
View article: Self-oligomerization regulates stability of survival motor neuron protein isoforms by sequestering an SCF <sup>Slmb</sup> degron
Self-oligomerization regulates stability of survival motor neuron protein isoforms by sequestering an SCF <sup>Slmb</sup> degron Open
SMN protein levels inversely correlate with the severity of spinal muscular atrophy. The SCF Slmb E3 ligase complex interacts with a degron embedded within the C-terminal self-oligomerization domain of SMN. The findings elucidate a model w…
View article: Correction: Human mutations in integrator complex subunits link transcriptome integrity to brain development
Correction: Human mutations in integrator complex subunits link transcriptome integrity to brain development Open
[This corrects the article DOI: 10.1371/journal.pgen.1006809.].
View article: Human mutations in integrator complex subunits link transcriptome integrity to brain development
Human mutations in integrator complex subunits link transcriptome integrity to brain development Open
Integrator is an RNA polymerase II (RNAPII)-associated complex that was recently identified to have a broad role in both RNA processing and transcription regulation. Importantly, its role in human development and disease is so far largely …
View article: Molecular basis for the interaction between Integrator subunits IntS9 and IntS11 and its functional importance
Molecular basis for the interaction between Integrator subunits IntS9 and IntS11 and its functional importance Open
Significance The Integrator complex (INT) has important functions in the 3′-end processing of noncoding RNAs and RNA polymerase II transcription. The INT contains at least 14 subunits, but its molecular mechanism of action is still poorly …
View article: Self-oligomerization regulates stability of Survival Motor Neuron (SMN) protein isoforms by sequestering an SCF<sup>Slmb</sup>degron
Self-oligomerization regulates stability of Survival Motor Neuron (SMN) protein isoforms by sequestering an SCF<sup>Slmb</sup>degron Open
Spinal muscular atrophy (SMA) is caused by homozygous mutations in human SMN1 . Expression of a duplicate gene ( SMN2 ) primarily results in skipping of exon 7 and production of an unstable protein isoform, SMNΔ7. Although SMN2 exon skippi…