David Blacker
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View article: A perspective of persons with Parkinson's disease on the contribution of alpha-synuclein seed amplification assay biomarker to the diagnosis of Parkinson's disease
A perspective of persons with Parkinson's disease on the contribution of alpha-synuclein seed amplification assay biomarker to the diagnosis of Parkinson's disease Open
Alpha-synuclein is a normal protein, but misfolded forms in the cerebrospinal fluid can be detected using the alpha-synuclein seed amplification assay (αSyn-SAA), a potential biomarker for Parkinson's disease (PD). Some experts consider th…
View article: <scp>FIGHT‐PD</scp>: A feasibility study of periodized boxing training for Parkinson disease
<span>FIGHT‐PD</span>: A feasibility study of periodized boxing training for Parkinson disease Open
Background Boxing training has become a popular form of exercise for people with Parkinson disease (PD). There is a dearth of high‐quality feasibility, safety, and efficacy data on boxing training for PD. Feasibility of Instituting Graduat…
View article: Ultra-Long Transfers for Endovascular Thrombectomy—Mission Impossible?: The Australia-New Zealand Experience
Ultra-Long Transfers for Endovascular Thrombectomy—Mission Impossible?: The Australia-New Zealand Experience Open
Background: Endovascular thrombectomy (EVT) access in remote areas is limited. Preliminary data suggest that long distance transfers for EVT may be beneficial; however, the magnitude and best imaging strategy at the referring center remain…
View article: 2237 Results of the feasibility of instituting graduated high intensity training for parkinson disease (FIGHT-PD) study of non-contact boxing exercise
2237 Results of the feasibility of instituting graduated high intensity training for parkinson disease (FIGHT-PD) study of non-contact boxing exercise Open
Objectives To determine the feasibility, tolerability and safety of a 15 week block periodized, auto regulated, non-contact boxing training program for early PD. Methods Participants were recruited from an existing data base, then screened…
View article: Improving Engagement of Stroke Survivors Using Desktop Virtual Reality-Based Serious Games for Upper Limb Rehabilitation: A Multiple Case Study
Improving Engagement of Stroke Survivors Using Desktop Virtual Reality-Based Serious Games for Upper Limb Rehabilitation: A Multiple Case Study Open
Engagement with upper limb rehabilitation post-stroke can improve rehabilitation outcomes. Virtual Reality can be used to make rehabilitation more engaging. In this paper, we propose a multiple case study to determine: (1) whether game des…
View article: Preventive antibiotic therapy in acute stroke patients: A systematic review and meta-analysis of individual patient data of randomized controlled trials
Preventive antibiotic therapy in acute stroke patients: A systematic review and meta-analysis of individual patient data of randomized controlled trials Open
Introduction Infection after stroke is associated with unfavorable outcome. Randomized controlled studies did not show benefit of preventive antibiotics in stroke but lacked power for subgroup analyses. Aim of this study is to assess wheth…
View article: 061 Feasibility of instituting graduated high intensity training for parkinson disease (FIGHT-PD); a non-contact boxing exercise study
061 Feasibility of instituting graduated high intensity training for parkinson disease (FIGHT-PD); a non-contact boxing exercise study Open
Objectives Preliminary evidence suggests non-contact boxing exercise is feasible and possibly beneficial for Parkinson Disease (PD). Current studies lack detailed description of component elements and documentation of exercise intensity. W…
View article: 098 Stroke-like migraine attacks after radiation therapy: Be SMART and order an EEG
098 Stroke-like migraine attacks after radiation therapy: Be SMART and order an EEG Open
Background Seizures may be a feature of SMART (stroke-like migraine attacks after radiation therapy) syndrome but their role in the pathophysiology and clinical presentation is unclear. Method The clinical and investigation findings in a s…
View article: Pluralism’s Surprises
Pluralism’s Surprises Open
Honest philosophy welcomes relevant contributions from any source.Responding to a perceived lack of acuity regarding the notion of pluralism in education, Emily Wenneborg suggests that there are valuable conceptual resources to be drawn fr…
View article: Factors Associated With 90-Day Readmission After Stroke or Transient Ischemic Attack
Factors Associated With 90-Day Readmission After Stroke or Transient Ischemic Attack Open
Background and Purpose— Readmissions after stroke are common and appear to be associated with comorbidities or disability-related characteristics. In this study, we aimed to determine the patient and health-system level factors associated …
View article: Poly-arginine-18 peptides do not exacerbate bleeding, or improve functional outcomes following collagenase-induced intracerebral hemorrhage in the rat
Poly-arginine-18 peptides do not exacerbate bleeding, or improve functional outcomes following collagenase-induced intracerebral hemorrhage in the rat Open
Overall, both R18 and R18D appeared to be safe when administered during a period of ongoing bleeding following ICH. Neither peptide appears to have any statistically significant effect in reducing lesion volume or improving functional reco…
View article: Indigenous stroke care: differences, challenges and a need for change
Indigenous stroke care: differences, challenges and a need for change Open
Indigenous peoples internationally experience stroke at a higher rate and at a younger age than non‐indigenous peoples,1-7 yet relatively little is known about treatments in the acute stages post‐stroke, access to rehabilitation services o…
View article: Poly-Arginine Peptides R18 and R18D Improve Functional Outcomes After Endothelin-1-Induced Stroke in the Sprague Dawley Rat
Poly-Arginine Peptides R18 and R18D Improve Functional Outcomes After Endothelin-1-Induced Stroke in the Sprague Dawley Rat Open
We have previously demonstrated that R18 and its d-enantiomer, R18D, are neuroprotective at 24 hours following intraluminal filament occlusion of the middle cerebral artery (MCAO) in the rat. This study examined R18 and R18D effectiveness …
View article: The Illegitimacy of Student Debt
The Illegitimacy of Student Debt Open
Readers are free to copy, display, and distribute this article, as long as the work is attributed to the author(s) and Cultural Logic, it is distributed for non-commercial purposes only, and no alteration or transformation is made in the w…
View article: Selected state of the art research in internal medicine, 2017
Selected state of the art research in internal medicine, 2017 Open
In late 2017, the specialty editors of the Internal Medicine Journal (IMJ) were tasked with providing a summary of their particular discipline of internal medicine. The result was a summary of selected ‘state of the art’ papers for 10 disc…
View article: Comparison of neuroprotective efficacy of poly-arginine R18 and R18D (D-enantiomer) peptides following permanent middle cerebral artery occlusion in the Wistar rat and in vitro toxicity studies
Comparison of neuroprotective efficacy of poly-arginine R18 and R18D (D-enantiomer) peptides following permanent middle cerebral artery occlusion in the Wistar rat and in vitro toxicity studies Open
We have previously demonstrated that arginine-rich and poly-arginine peptides possess potent neuroprotective properties, with poly-arginine peptide R18 identified as being highly effective at reducing infarct volume following middle cerebr…
View article: Prescription of antihypertensive medication at discharge influences survival following stroke
Prescription of antihypertensive medication at discharge influences survival following stroke Open
People who are prescribed antihypertensive medications at discharge from hospital after a stroke or TIA demonstrate better cardiovascular and all-cause survival outcomes than those not prescribed these agents.
View article: The importance of left atrial volume assessment in identifying the cause of ischemic stroke
The importance of left atrial volume assessment in identifying the cause of ischemic stroke Open
Separating cardioembolic from large artery stroke has important treatment implications. We investigated whether echocardiography could improve Cardioembolic Stroke (CES) prediction compared with traditional measures and cholesterol biomark…
View article: Penumbral Freeze: Travel Distance and Delays Provide an Opportunity to Study Prerecanalization Therapy neuroprotection
Penumbral Freeze: Travel Distance and Delays Provide an Opportunity to Study Prerecanalization Therapy neuroprotection Open
Excitingly, stroke patients who had previously
View article: Practice Patterns for Neurosurgical Utilization and Outcome in Acute Intracerebral Hemorrhage: Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trials 1 and 2 Studies
Practice Patterns for Neurosurgical Utilization and Outcome in Acute Intracerebral Hemorrhage: Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trials 1 and 2 Studies Open
BACKGROUND The prognosis in acute spontaneous intracerebral hemorrhage (ICH) is related to hematoma volume, where >30 mL is commonly used to define large ICH as a threshold for neurosurgical decompression but without clear supporting evide…
View article: Outcomes of Endovascular Thrombectomy with and without Thrombolysis for Acute Large Artery Ischaemic Stroke at a Tertiary Stroke Centre
Outcomes of Endovascular Thrombectomy with and without Thrombolysis for Acute Large Artery Ischaemic Stroke at a Tertiary Stroke Centre Open
Background and Purpose: Endovascular thrombectomy (EVT) improves the functional outcome when added to best medical therapy, including alteplase, in patients with acute ischaemic stroke secondary to large vessel occlusion (LVO) in the anter…
View article: Accuracy of Stroke Identification by Paramedics in a Metropolitan Prehospital Setting: A Cohort Study
Accuracy of Stroke Identification by Paramedics in a Metropolitan Prehospital Setting: A Cohort Study Open
Introduction Acute stroke is a medical emergency. Identifying patients suffering a stroke is crucial if paramedics are to maximise delivery of appropriate management. One suggested screening tool to identify stroke is ‘FAST’ (Face, Arms, S…