David Chien Lye
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View article: Cardiovascular complications in acute dengue infection: a population-based cohort study
Cardiovascular complications in acute dengue infection: a population-based cohort study Open
National-Medical-Research-Council, Singapore.
View article: Circulating biomarkers predict platelet recovery in adult dengue patients with thrombocytopenia receiving prophylactic platelet transfusion
Circulating biomarkers predict platelet recovery in adult dengue patients with thrombocytopenia receiving prophylactic platelet transfusion Open
Our findings highlight that individual differences in immune response exist regardless of transfusion, underscoring the potential for personalized treatment in managing hospitalized adult dengue patients. The identified immune signature su…
View article: Approaches for estimating COVID-19 vaccine effectiveness using observational data in administrative databases: a systematic review
Approaches for estimating COVID-19 vaccine effectiveness using observational data in administrative databases: a systematic review Open
Background COVID-19 vaccine policy relied on observational vaccine-effectiveness (VE) studies conducted amid rapid variant turnover, evolving schedules, and shifting surveillance, yielding substantial heterogeneity in methodological approa…
View article: Core Outcome Measurement Set for Clinical Trials in Dengue: An International Delphi Consensus Study ‘DEN-CORE’
Core Outcome Measurement Set for Clinical Trials in Dengue: An International Delphi Consensus Study ‘DEN-CORE’ Open
Summary Dengue, caused by any one of four distinct virus serotypes, is the most rapidly spreading mosquito-borne viral disease worldwide. It is a primary arboviral infection with increasing global incidence, driven by climate change, urban…
View article: Impact of Vaccination-Differentiated Public Health and Social Measures on Vaccine Uptake Among the Vaccine Hesitant
Impact of Vaccination-Differentiated Public Health and Social Measures on Vaccine Uptake Among the Vaccine Hesitant Open
Overall, the findings support the effectiveness of vaccination-differentiated public health and social measures in increasing vaccine uptake rates among vaccine-hesitant persons. However, the compelling evidence for complementary policies …
View article: The impact of blood pressure indicators and shock indices on hazard of complicated dengue in hospitalized adults with dengue infection
The impact of blood pressure indicators and shock indices on hazard of complicated dengue in hospitalized adults with dengue infection Open
Blood pressure monitoring is crucial for early detection of complicated dengue. We investigated the association between blood pressure indicators and complicated dengue hazard over the course of dengue hospitalization in a well-characteriz…
View article: Modeling Antibody Kinetics Post‐mRNA Booster Vaccination and Protection Durations Against SARS‐CoV‐2 Infection
Modeling Antibody Kinetics Post‐mRNA Booster Vaccination and Protection Durations Against SARS‐CoV‐2 Infection Open
Understanding the dynamics of SARS‐CoV‐2 antibody levels post‐booster vaccination is important to inform their durations of protection. Longitudinal antibody data was collected on the day of booster vaccination, as well as 28, 180, and 360…
View article: Should Cefoxitin Non-Susceptibility in Ceftriaxone-Susceptible E. coli and K. pneumoniae Prompt Concerns Regarding Plasmid-Mediated AmpC Resistance? A Genomic Characterization and Summary of Treatment Challenges in Singapore
Should Cefoxitin Non-Susceptibility in Ceftriaxone-Susceptible E. coli and K. pneumoniae Prompt Concerns Regarding Plasmid-Mediated AmpC Resistance? A Genomic Characterization and Summary of Treatment Challenges in Singapore Open
Objectives: Plasmid-mediated AmpC beta-lactamases represent a growing clinical concern in Enterobacterales, with challenges in diagnostic approaches, limited data on clinical outcomes, and our incomplete understanding of their regulatory m…
View article: Dengue infection elicits skin tissue-resident and circulating CD8<sup>+</sup> T-cells associated with protection from hospitalization
Dengue infection elicits skin tissue-resident and circulating CD8<sup>+</sup> T-cells associated with protection from hospitalization Open
Dengue is spreading globally and there is urgent need to define immune correlates of protection against this disease. Immune responses against dengue viruses have been studied in blood samples of dengue patients. However, dengue virus infe…
View article: Respiratory syncytial virus hospitalization costs, rates, and seasonality in Asia: a systematic review and meta-analysis
Respiratory syncytial virus hospitalization costs, rates, and seasonality in Asia: a systematic review and meta-analysis Open
Jue Tao Lim is supported by the Lee Kong Chian School of Medicine-Ministry of Education Start-Up Grant. YSL is funded by the National Centre for Infectious Diseases Department Research Fund.
View article: Cefepime Versus Carbapenem Therapy for the Treatment of Invasive Infections With Inducible Chromosomal AmpC-Producing Enterobacterales: A Systematic Review and Meta-analysis
Cefepime Versus Carbapenem Therapy for the Treatment of Invasive Infections With Inducible Chromosomal AmpC-Producing Enterobacterales: A Systematic Review and Meta-analysis Open
Background The optimal antibiotic choice for AmpC-producing Enterobacterales bloodstream infections (BSIs) and complicated urinary tract infections (cUTIs) remains to be clearly defined. Guidance from the Infectious Diseases Society of Ame…
View article: Acute and Postacute Health Care Utilization and Costs After Dengue Infection: A Population-Based Cohort Study
Acute and Postacute Health Care Utilization and Costs After Dengue Infection: A Population-Based Cohort Study Open
Background Emerging evidence suggests that postacute sequelae may arise following dengue infection. There has been no quantification of the risk and burden of acute and postacute health care utilization and cost due to dengue. Methods We u…
View article: Long-term multisystemic sequelae post-hospitalisation for Omicron COVID-19 vs influenza: A retrospective cohort study
Long-term multisystemic sequelae post-hospitalisation for Omicron COVID-19 vs influenza: A retrospective cohort study Open
Risks of cognitive impairment/fatigue were increased while risk of cardiac sequelae was significantly lower post-COVID-19 vs influenza in unboosted/unvaccinated individuals. Vaccination for COVID-19/influenza remains important during endem…
View article: Novel NUDCD1 gene variant predisposes to severe COVID-19 disease in Asians through modulation of antiviral DHX15- and MAVS-mediated signalling
Novel NUDCD1 gene variant predisposes to severe COVID-19 disease in Asians through modulation of antiviral DHX15- and MAVS-mediated signalling Open
Background Genome-wide associative studies can potentially uncover novel pathways which modulate anti-viral immune responses against SARS-CoV-2 or identify drivers of severe disease. To date, these studies have yielded loci mostly in non-f…
View article: Long COVID-19 autoantibodies and their potential effect on fertility
Long COVID-19 autoantibodies and their potential effect on fertility Open
Impaired spermatogenesis has been reported in coronavirus disease 2019 (COVID-19) patients. However, the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on male fertility remains unclear. The purpose of this multicen…
View article: Real-World Effectiveness of Boosting Against Omicron Hospitalization in Older Adults, Stratified by Frailty
Real-World Effectiveness of Boosting Against Omicron Hospitalization in Older Adults, Stratified by Frailty Open
Background/Objectives: Older adults with frailty are at-risk of worse outcomes following respiratory-viral-infections such as COVID-19. Data on effectiveness of vaccination/boosting in frail older adults during Omicron is lacking. Methods:…
View article: Cardiac Events in Adults Hospitalized for Respiratory Syncytial Virus vs COVID-19 or Influenza
Cardiac Events in Adults Hospitalized for Respiratory Syncytial Virus vs COVID-19 or Influenza Open
Importance Respiratory viral infections (RVIs) are associated with elevated cardiovascular risk; however, less is known about cardiac complications after hospitalization for respiratory syncytial virus (RSV) vs other vaccine-preventable RV…
View article: Omicron SARS-CoV-2 outcomes in vaccinated individuals with heart failure and ischaemic heart disease
Omicron SARS-CoV-2 outcomes in vaccinated individuals with heart failure and ischaemic heart disease Open
Introduction: Outcomes after SARS-CoV 2 Omicron infection in patients with heart failure (HF) and ischaemic heart disease (IHD) remain poorly defined. Method: In a highly vaccinated cohort of adult Singapore citizens and permanent resident…
View article: Convalescent plasma for the treatment of patients with COVID-19: the Singapore experience and lessons learnt
Convalescent plasma for the treatment of patients with COVID-19: the Singapore experience and lessons learnt Open
Introduction: We report Singapore’s convalescent plasma (CP) programme during the first year of the COVID-19 pandemic. Based on historical data and its potential therapeutic promise, CP was offered as an experimental treatment option for s…
View article: Risk of New-Onset Type 2 Diabetes Among Vaccinated Adults After Omicron or Delta Variant SARS-CoV-2 Infection
Risk of New-Onset Type 2 Diabetes Among Vaccinated Adults After Omicron or Delta Variant SARS-CoV-2 Infection Open
This cohort study estimates the risk of new-onset type 2 diabetes after Delta or Omicron variant SARS-CoV-2 infection among vaccinated adults in Singapore.
View article: Early neutrophil responses are potential biomarkers to predict severe COVID-19 in adults
Early neutrophil responses are potential biomarkers to predict severe COVID-19 in adults Open
In the early COVID-19 pandemic, the strain on healthcare facilities highlighted the need for reliable biomarkers to predict progression to severe COVID-19. Neutrophils, the most abundant leukocytes in circulation, are early defenders again…
View article: Long-term Sequelae Following Dengue Infection vs SARS-CoV-2 Infection in a Pediatric Population: A Retrospective Cohort Study
Long-term Sequelae Following Dengue Infection vs SARS-CoV-2 Infection in a Pediatric Population: A Retrospective Cohort Study Open
Background Long-term postacute sequelae following SARS-CoV-2 infection in children have been extensively documented. However, while persistence of chronic symptoms following pediatric dengue infection has been documented in small prospecti…