David Brand
YOU?
Author Swipe
View article: Itreg cells Ameliorates MOG-induced brain inflammation via endowing DC tolerogenic capacity predominantly via TGF-beta signaling mediated AKT/mTOR pathway inhibition
Itreg cells Ameliorates MOG-induced brain inflammation via endowing DC tolerogenic capacity predominantly via TGF-beta signaling mediated AKT/mTOR pathway inhibition Open
iTreg cells play a pivotal role in orchestrating the formation of a robust immunoregulatory circuit involving tolerogenic DCs, which holds significant promise as a target for the development of innovative immunotherapeutic strategies for a…
View article: Schwann cell-secreted frizzled-related protein 1 dictates neuroinflammation and peripheral nerve degeneration after neurotrauma
Schwann cell-secreted frizzled-related protein 1 dictates neuroinflammation and peripheral nerve degeneration after neurotrauma Open
Neurotrauma in limbs can induce sustained neuroinflammation, resulting in persistent disruption of nerve tissue architecture and retardation of axon regrowth. Despite macrophage-mediated inflammation promoting the removal of necrotic neura…
View article: A tri-layer tissue engineering heart valve scaffold based on atelocollagen, hyaluronic acid, and elastin
A tri-layer tissue engineering heart valve scaffold based on atelocollagen, hyaluronic acid, and elastin Open
Aim: This study aims to fabricate and characterise a novel tri-layer scaffold based on type I atelocollagen, hyaluronic acid (HA), and a novel fibrillar elastin gel, mimicking the native heart valve leaflets in structure, composition, and …
View article: C-reactive protein lowers the serum level of IL-17, but not TNF-α, and decreases the incidence of collagen-induced arthritis in mice
C-reactive protein lowers the serum level of IL-17, but not TNF-α, and decreases the incidence of collagen-induced arthritis in mice Open
The biosynthesis of C-reactive protein (CRP) in the liver is increased in inflammatory diseases including rheumatoid arthritis. Previously published data suggest a protective function of CRP in arthritis; however, the mechanism of action o…
View article: A programmable arthritis-specific receptor for guided articular cartilage regenerative medicine
A programmable arthritis-specific receptor for guided articular cartilage regenerative medicine Open
Objective Investigational cell therapies have been developed as disease-modifying agents for the treatment of osteoarthritis (OA), including those that inducibly respond to inflammatory factors driving OA progression. However, dysregulated…
View article: Roles of swallowing and belching in different phenotypes of gastroesophageal reflux disease
Roles of swallowing and belching in different phenotypes of gastroesophageal reflux disease Open
Background The contributions of swallowing and belching to specific gastroesophageal reflux disease (GERD) phenotypes are unclear. Methods This study retrospectively analyzed esophageal pH/impedance studies, comparing reflux events precede…
View article: A Hybrid Pressureless Silver Sintering Technology for High-Power Density Electronics
A Hybrid Pressureless Silver Sintering Technology for High-Power Density Electronics Open
Aerospace and defense applications present unique challenges for material suppliers. As increasing adoption of advanced semiconductor materials and Diverse Accessible Heterogeneous Integration technologies, power density of defense and aer…
View article: A Hybrid Pressure-less Silver Sintering Technology for High-power Density Electronics
A Hybrid Pressure-less Silver Sintering Technology for High-power Density Electronics Open
Integration of smaller, higher-functioning devices and use of advanced high thermal chip structures present thermal management challenges in the aerospace sector where reliability is the top priority and fail-safe processes/materials are t…
View article: Drive, instinct, reflex—Applications to treatment of anxiety, depressive and addictive disorders
Drive, instinct, reflex—Applications to treatment of anxiety, depressive and addictive disorders Open
The neuropsychoanalytic approach solves important aspects of how to use our understanding of the brain to treat patients. We describe the neurobiology underlying motivation for healthy behaviors and psychopathology. We have updated Freud’s…
View article: Characterization of Non-Invasively Induced Post-Traumatic Osteoarthritis in Mice
Characterization of Non-Invasively Induced Post-Traumatic Osteoarthritis in Mice Open
The pathophysiology of post-traumatic arthritis (PTOA) is not fully understood. This study used non-invasive repetitive mechanical loading (ML) mouse models to study biochemical, biomechanical, and pain-related behavioral changes induced i…
View article: Role of Citrullinated Collagen in Autoimmune Arthritis
Role of Citrullinated Collagen in Autoimmune Arthritis Open
Citrullination of proteins plays an important role in protein function and it has recently become clear that citrullinated proteins play a role in immune responses. In this study we examined how citrullinated collagen, an extracellular mat…
View article: Beta-caryophyllene prevents the defects in trabecular bone caused by Vitamin D deficiency through pathways instated by increased expression of klotho
Beta-caryophyllene prevents the defects in trabecular bone caused by Vitamin D deficiency through pathways instated by increased expression of klotho Open
Aims This study investigated the effects of β-caryophyllene (BCP) on protecting bone from vitamin D deficiency in mice fed on a diet either lacking (D-) or containing (D+) vitamin D. Methods A total of 40 female mice were assigned to four …
View article: Correction: Influence of the shared epitope on the elicitation of experimental autoimmune arthritis biomarkers
Correction: Influence of the shared epitope on the elicitation of experimental autoimmune arthritis biomarkers Open
[This corrects the article DOI: 10.1371/journal.pone.0250177.].
View article: 1,25-Dihydroxyvitamin D3 and 20-Hydroxyvitamin D3 Upregulate LAIR-1 and Attenuate Collagen Induced Arthritis
1,25-Dihydroxyvitamin D3 and 20-Hydroxyvitamin D3 Upregulate LAIR-1 and Attenuate Collagen Induced Arthritis Open
Vitamin D plays a crucial role in regulation of the immune response. However, treatment of autoimmune diseases with 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] doses sufficient to be effective is prohibitive due to its calcemic and toxic effect…
View article: A Bilayer Osteochondral Scaffold with Self‐Assembled Monomeric Collagen Type‐I, Type‐II, and Polymerized Chondroitin Sulfate Promotes Chondrogenic and Osteogenic Differentiation of Mesenchymal Stem Cells
A Bilayer Osteochondral Scaffold with Self‐Assembled Monomeric Collagen Type‐I, Type‐II, and Polymerized Chondroitin Sulfate Promotes Chondrogenic and Osteogenic Differentiation of Mesenchymal Stem Cells Open
Osteochondral (OC) injuries are suffered by over 40 million patients in Europe alone. Tissue‐engineering approaches may provide a more promising alternative over current treatments by potentially eliminating the need for revision surgery a…
View article: 20S-Hydroxyvitamin D3, a Secosteroid Produced in Humans, Is Anti-Inflammatory and Inhibits Murine Autoimmune Arthritis
20S-Hydroxyvitamin D3, a Secosteroid Produced in Humans, Is Anti-Inflammatory and Inhibits Murine Autoimmune Arthritis Open
The ability to use large doses of vitamin D3 (D3) to chronically treat autoimmune diseases such as rheumatoid arthritis (RA) is prohibitive due to its calcemic effect which can damage vital organs. Cytochrome P450scc (CYP11A1) is able to c…
View article: Influence of the shared epitope on the elicitation of experimental autoimmune arthritis biomarkers
Influence of the shared epitope on the elicitation of experimental autoimmune arthritis biomarkers Open
Our previous studies have shown that inoculation of the oral cavity of “humanized” B6.DR1/4 mice with the periodontal pathogen Porphyromonas gingivalis results in an increase in the percentage of circulating Th17 cells, loss of bone and an…
View article: Leukocyte-associated immunoglobulin-like receptor 1 inhibits T-cell signaling by decreasing protein phosphorylation in the T-cell signaling pathway
Leukocyte-associated immunoglobulin-like receptor 1 inhibits T-cell signaling by decreasing protein phosphorylation in the T-cell signaling pathway Open
Multiple observations implicate T-cell dysregulation as a central event in the pathogenesis of rheumatoid arthritis. Here, we investigated mechanisms for suppressing T-cell activation via the inhibitory receptor leukocyte-associated immuno…
View article: Ameliorating effects of Gö6976, a pharmacological agent that inhibits protein kinase D, on collagen-induced arthritis
Ameliorating effects of Gö6976, a pharmacological agent that inhibits protein kinase D, on collagen-induced arthritis Open
Toll-like receptor (TLR) signaling can contribute to the pathogenesis of arthritis. Disruption of TLR signaling at early stages of arthritis might thereby provide an opportunity to halt the disease progression and ameliorate outcomes. We p…
View article: Off-Target Deletion of Conditional Dbc1 Allele in the Foxp3YFP-Cre Mouse Line under Specific Setting
Off-Target Deletion of Conditional Dbc1 Allele in the Foxp3YFP-Cre Mouse Line under Specific Setting Open
The Cre-LoxP conditional knockout strategy has been used extensively to study gene function in a specific cell-type. In this study, the authors tried to engineer mice in which the Dbc1 gene is conditionally knocked out in Treg cells. Unexp…
View article: Porphyromonas gingivalis oral infection exacerbates the development and severity of collagen-induced arthritis
Porphyromonas gingivalis oral infection exacerbates the development and severity of collagen-induced arthritis Open
Introduction: Clinical studies suggest a direct influence of periodontal disease (PD) on serum inflammatory markers and disease assessment of patients with established rheumatoid arthritis (RA). However, the influence of PD on arthritis de…
View article: RETRACTED: lnc<scp>RNA</scp>‐<scp>PDPK</scp>2P promotes hepatocellular carcinoma progression through the <scp>PDK</scp>1/<scp>AKT</scp>/Caspase 3 pathway
RETRACTED: lnc<span>RNA</span>‐<span>PDPK</span>2P promotes hepatocellular carcinoma progression through the <span>PDK</span>1/<span>AKT</span>/Caspase 3 pathway Open
Hepatocellular carcinoma ( HCC ) is a malignancy with one of the worst prognoses. Long noncoding RNA (lnc RNA ) are emerging as an important regulator of gene expression and function, leading to the development of cancer. The aim of this s…
View article: Integrated analysis of 10 lymphoma datasets identifies E2F8 as a key regulator in Burkitt's lymphoma and mantle cell lymphoma.
Integrated analysis of 10 lymphoma datasets identifies E2F8 as a key regulator in Burkitt's lymphoma and mantle cell lymphoma. Open
Burkitt's lymphoma (BURK), diffuse large B-cell lymphoma (DLBCL) and mantle cell lymphoma (MCL) are three main types of B-cell lymphomas. This study aimed to compare the differences of affected biological functions and pathways, as well as…
View article: N‐acetylcysteine targets 5 lipoxygenase‐derived, toxic lipids and can synergize with prostaglandin E<sub>2</sub> to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice
N‐acetylcysteine targets 5 lipoxygenase‐derived, toxic lipids and can synergize with prostaglandin E<sub>2</sub> to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice Open
Objectives N‐acetylcysteine (NAC) is a clinically approved thiol‐containing redox modulatory compound currently in trials for many neurological and psychiatric disorders. Although generically labeled as an “antioxidant,” poor understanding…