David Brasse
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View article: Validation of a FLASH-ready 25 MeV proton beamline for preclinical radiobiology experiments
Validation of a FLASH-ready 25 MeV proton beamline for preclinical radiobiology experiments Open
Objective . Ultra-high dose rate irradiation (FLASH) is a promising way to reduce the adverse effects of radiotherapy treatment. However, the impact of dosimetric parameters on the FLASH effect is still not well understood and few devices …
View article: Experimental Uses of Positronium and Potential for Biological Applications
Experimental Uses of Positronium and Potential for Biological Applications Open
International audience
View article: Geometrical Characterization of an Inorganic Scintillator Detector for Proton Therapy Using a Micrometer-Scale Ion Beam
Geometrical Characterization of an Inorganic Scintillator Detector for Proton Therapy Using a Micrometer-Scale Ion Beam Open
International audience
View article: Imaging Capabilities of the IRIS and IRIS XL-260 PET/CT Systems for High-Throughput Imaging: A Quantification Cross-Validation Study
Imaging Capabilities of the IRIS and IRIS XL-260 PET/CT Systems for High-Throughput Imaging: A Quantification Cross-Validation Study Open
International audience
View article: 64CuCl2 PET Imaging of 4T1-Related Allograft of Triple-Negative Breast Cancer in Mice
64CuCl2 PET Imaging of 4T1-Related Allograft of Triple-Negative Breast Cancer in Mice Open
64CuCl2 is an economic radiotracer for oncologic PET investigations. In the present study, we characterized the uptake of 64CuCl2 in vivo by µPET/CT in an allograft 4T1-related mouse model (BALB/c) of advanced breast cancer. 18F-FDG was us…
View article: Evaluation of Monte-Carlo-based System Response Matrix Completeness and its Impact on Image Quality in Positron Emission Tomography
Evaluation of Monte-Carlo-based System Response Matrix Completeness and its Impact on Image Quality in Positron Emission Tomography Open
A major strength of iterative algorithms used in positron emission tomography (PET) lies in their abilities to introduce precise models of the physics at play, which includes the statistical nature of the detection processes, and a detaile…
View article: F autoradiography with the Mimosa-28: Characterisation and Application
F autoradiography with the Mimosa-28: Characterisation and Application Open
International audience
View article: A near-infrared fluorogenic dimer enables background-free imaging of endogenous GPCRs in living mice
A near-infrared fluorogenic dimer enables background-free imaging of endogenous GPCRs in living mice Open
A near-infrared emitting fluorogenic dimer with environment-sensitive folding and exceptional brightness enables background-free and target-specific imaging of the naturally expressed oxytocin GPCR in living mice.
View article: Dosimetry and characterization of a 25‐MeV proton beam line for preclinical radiobiology research
Dosimetry and characterization of a 25‐MeV proton beam line for preclinical radiobiology research Open
Purpose With the increase in proton therapy centers, there is a growing need to make progress in preclinical proton radiation biology to give accessible data to medical physicists and practicing radiation oncologists. Methods A cyclotron u…
View article: Rere-dependent Retinoic Acid signaling controls brain asymmetry and handedness
Rere-dependent Retinoic Acid signaling controls brain asymmetry and handedness Open
While the vertebrate brain appears largely bilaterally symmetrical in humans, it presents local morphological Left-Right (LR) asymmetries as, for instance, in the petalia . Moreover, higher functions such as speech or handedness are asymme…
View article: Base/Cryptand/Metal‐Free Automated Nucleophilic Radiofluorination of [<sup>18</sup>F]FDOPA from Iodonium Salts: Importance of Hydrogen Carbonate Counterion
Base/Cryptand/Metal‐Free Automated Nucleophilic Radiofluorination of [<sup>18</sup>F]FDOPA from Iodonium Salts: Importance of Hydrogen Carbonate Counterion Open
As evidenced by the number of publications and patents published in the last years, the radiosynthesis of 6‐[ 18 F]fluoro‐3,4‐dihydroxy‐ L ‐phenylalanine ([ 18 F]FDOPA) using the nucleophilic [ 18 F]F‐ process remains currently a challenge…
View article: Nanoengineered implant as a new platform for regenerative nanomedicine using 3D well-organized human cell spheroids
Nanoengineered implant as a new platform for regenerative nanomedicine using 3D well-organized human cell spheroids Open
In tissue engineering, it is still rare today to see clinically transferable strategies for tissue-engineered graft production that conclusively offer better tissue regeneration than the already existing technologies, decreased recovery ti…
View article: Effect of Carbidopa on <sup>18</sup>F-FDOPA Uptake in Insulinoma: From Cell Culture to Small-Animal PET Imaging
Effect of Carbidopa on <sup>18</sup>F-FDOPA Uptake in Insulinoma: From Cell Culture to Small-Animal PET Imaging Open
Carbidopa did not influence in vitro 18F-FDOPA accumulation in RIN-m5F cells but improved insulinoma imaging in vivo. Our findings increase current knowledge about the 18F-FDOPA uptake profile of RIN-m5F cells and a related xenograft model…