David Brossier
YOU?
Author Swipe
View article: Formal guidelines from an expert panel: intensive care unit medical staffing, organisation and working hours to improve quality of life at work in France
Formal guidelines from an expert panel: intensive care unit medical staffing, organisation and working hours to improve quality of life at work in France Open
Background Intensive care units (ICU) are characterized by high medical assistance costs and great complexity. Recommendations to determine the needs of medical staff are scarce, generating appreciable variability. The French Intensive Car…
View article: The severity of the first occurrence of bronchiolitis increased the risk of developing asthma symptoms
The severity of the first occurrence of bronchiolitis increased the risk of developing asthma symptoms Open
Aim The relationship between bronchiolitis and asthma is complex. We assessed whether patients admitted to a paediatric intensive care unit (PICU) with bronchiolitis had a greater risk of developing asthma than patients admitted to a paedi…
View article: Infants with bronchiolitis with high-flow nasal cannula in the paediatric ward. Is there a role for the ROXi (Respiratory rate–Oxygenation index) to predict transfer requirement to the PICU?
Infants with bronchiolitis with high-flow nasal cannula in the paediatric ward. Is there a role for the ROXi (Respiratory rate–Oxygenation index) to predict transfer requirement to the PICU? Open
Introduction: The respiratory rate–oxygenation index (ROXi) has been shown to be a reliable tool to predict the risk for HFNC failure in adult patients with lower respiratory tract infections. In paediatrics, the reliability of this index …
View article: Central role of the <i>ramAR</i> locus in the multidrug resistance in ESBL <i>-Enterobacterales</i>
Central role of the <i>ramAR</i> locus in the multidrug resistance in ESBL <i>-Enterobacterales</i> Open
The aim of this study was to evaluate the proportion of resistance to a temocillin, tigecycline, ciprofloxacin, and chloramphenicol phenotype called t2c2 that resulted from mutations within the ramAR locus among extended-spectrum β-lactama…
View article: How to follow the guidelines, when the appropriate fluid is missing?
How to follow the guidelines, when the appropriate fluid is missing? Open
Intravenous maintenance fluid therapy (IV-MFT) is probably the most prescribed drug in paediatric hospital care. Recently paediatric societies have produced evidence-based practice guidelines that recommend the use of balanced isotonic flu…
View article: How to follow the guidelines, when the appropriate fluid is missing?
How to follow the guidelines, when the appropriate fluid is missing? Open
Intravenous maintenance fluid therapy (IV-MFT) is probably the most prescribed drug in paediatric hospital care. Recently paediatric societies have produced evidence-based practice guidelines that recommend the use of balanced isotonic flu…
View article: ROX (Respiratory rate–OXygenation) index to predict early response to high‐flow nasal cannula therapy in infants with viral bronchiolitis
ROX (Respiratory rate–OXygenation) index to predict early response to high‐flow nasal cannula therapy in infants with viral bronchiolitis Open
Introduction High‐flow nasal cannula (HFNC) is commonly used as first step respiratory support in infants with moderate‐to‐severe acute viral bronchiolitis (AVB). This device, however, fails to effectively manage respiratory distress in ab…
View article: ROX (Respiratory rate-OXygenation) index to predict early response to high-flow nasal cannula therapy in infants with viral bronchiolitis
ROX (Respiratory rate-OXygenation) index to predict early response to high-flow nasal cannula therapy in infants with viral bronchiolitis Open
Introduction High flow nasal cannula (HFNC) is commonly used as first step respiratory support in infants with moderate-to-severe acute viral bronchiolitis (AVB). This device, however, fails to effectively manage respiratory distress in ab…
View article: Evaluation of the SIMULRESP: A simulation software of child and teenager cardiorespiratory physiology
Evaluation of the SIMULRESP: A simulation software of child and teenager cardiorespiratory physiology Open
Background Mathematical models based on the physiology when programmed as a software can be used to teach cardiorespiratory physiology and to forecast the effect of various ventilatory support strategies. We developed a cardiorespiratory s…
View article: Brief resolved unexplained event: Severity-associated factors at admission in the pediatric emergency ward
Brief resolved unexplained event: Severity-associated factors at admission in the pediatric emergency ward Open
As prematurity is a factor associated with severe diagnosis, special attention should be given to this population, without subjecting them to multiple tests, since the main complication was found to be apnea or central hypoventilation. Pro…
View article: Evaluation of the SIMULRESP: a simulation software of child and teenager cardiorespiratory physiology
Evaluation of the SIMULRESP: a simulation software of child and teenager cardiorespiratory physiology Open
BACKGROUND: Mathematical models based on the physiology when programmed as a software can be used to teach cardiorespiratory physiology and to forecast the effect of various ventilatory support strategies. We developed a cardiorespiratory …
View article: Severe Traumatic Brain Injury in French-Speaking Pediatric Intensive Care Units: Study of Practices
Severe Traumatic Brain Injury in French-Speaking Pediatric Intensive Care Units: Study of Practices Open
Best strategies for managing severe pediatric traumatic brain injury (TBI) are not established, with wide variations among professional practices. The main objective of this study was to assess compliance with updated pediatric TBI managem…
View article: Impact of the French National Lockdown on Admissions to 14 Pediatric Intensive Care Units During the 2020 COVID-19 Pandemic–A Retrospective Multicenter Study
Impact of the French National Lockdown on Admissions to 14 Pediatric Intensive Care Units During the 2020 COVID-19 Pandemic–A Retrospective Multicenter Study Open
Background: After the COVID-19 pandemic reached France in January 2020, a national lockdown including school closures was officially imposed from March 17, 2020, to May 10, 2020. Pediatric intensive care units (PICUs) admit critically ill …
View article: Intravenous Maintenance Fluid Therapy in the Pediatric Acute and Critical Care Setting: A European Practice Survey. Intravenous Maintenance Fluids in Pediatric Practice: A European Survey
Intravenous Maintenance Fluid Therapy in the Pediatric Acute and Critical Care Setting: A European Practice Survey. Intravenous Maintenance Fluids in Pediatric Practice: A European Survey Open
Background: The ideal fluid for intravenous maintenance fluid therapy (IV-MFT) in acutely and critically ill children is controversial and evidence based clinical practice guidelines are lacking. The current prescribing practices remains u…
View article: 5PSQ-119 Proton pump inhibitor prescription patterns and associated complications in the paediatric intensive care unit
5PSQ-119 Proton pump inhibitor prescription patterns and associated complications in the paediatric intensive care unit Open
Background and importance Proton pump inhibitors (PPIs) are regularly prescribed in the paediatric intensive care unit (PICU) for prevention of stress ulcer and upper gastrointestinal bleed (UGIB). There is no clinical consensus regarding …
View article: Assessment of general emergency medicine physicians’ medical education regarding management of pediatric emergencies in western Normandy, France
Assessment of general emergency medicine physicians’ medical education regarding management of pediatric emergencies in western Normandy, France Open
Most general emergency physicians report caring for children despite a lack of medical education in pediatrics. Pediatric medical education as well as collaborations between general practitioners and specialized pediatric teams should be e…
View article: Validation Process of a High-Resolution Database in a Pediatric Intensive Care Unit -- Describing the Perpetual Patient's Validation
Validation Process of a High-Resolution Database in a Pediatric Intensive Care Unit -- Describing the Perpetual Patient's Validation Open
Objective: High data quality is essential to ensure the validity of clinical and research inferences based on it. However, these data quality assessments are often missing even though these data are used in daily practice and research. Our…
View article: Using machine learning models to predict oxygen saturation following ventilator support adjustment in critically ill children: A single center pilot study
Using machine learning models to predict oxygen saturation following ventilator support adjustment in critically ill children: A single center pilot study Open
This single center pilot study using machine learning predictive model resulted in an algorithm with poor accuracy. The comparison of machine learning models showed that bagged complex trees was a promising approach. However, there is a ne…
View article: Acute pediatric hyperammonemia: current diagnosis and management strategies
Acute pediatric hyperammonemia: current diagnosis and management strategies Open
Acute hyperammonemia may induce a neurologic impairment leading to an acute life-threatening condition. Coma duration, ammonia peak level, and hyperammonemia duration are the main risk factors of hyperammonemia-related neurologic deficits …
View article: Using machine learning models to predict oxygen saturation following ventilator support adjustment in critically ill children: a single center pilot study
Using machine learning models to predict oxygen saturation following ventilator support adjustment in critically ill children: a single center pilot study Open
Clinicians’ experts in mechanical ventilation are not continuously at each patient’s bedside in an intensive care unit to adjust mechanical ventilation settings and to analyze the impact of ventilator settings adjustments on gas exchange. …
View article: Assessment of Bohr and Enghoff Dead Space Equations in Mechanically Ventilated Children
Assessment of Bohr and Enghoff Dead Space Equations in Mechanically Ventilated Children Open
This study suggests that VD/VT Bohr and VD/VT Enghoff are not different when there is no hypoxemia (PaO2 /FIO2 > 300) except in the case of status asthmaticus. In subjects with a low PaO2 /FIO2 , the method to measure VD/VT must be reporte…