David Bunn
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View article: Dual Inhibition of sEH and COX-2 Improved Cognition in Alzheimer’s Disease via Enhanced Myogenic Response and Cerebral Artery Distensibility
Dual Inhibition of sEH and COX-2 Improved Cognition in Alzheimer’s Disease via Enhanced Myogenic Response and Cerebral Artery Distensibility Open
Genetic studies have linked EPHX2 (encoding soluble epoxide hydrolase, sEH) and PTGS2 (encoding cyclooxygenase-2, COX-2) to Alzheimer’s disease (AD). Elevated levels of sEH and COX-2 found in AD patients and animals suggest their involveme…
View article: CD14 in Salt‐Sensitive Hypertension‐Related Cognitive Impairments
CD14 in Salt‐Sensitive Hypertension‐Related Cognitive Impairments Open
Background Hypertension is a leading risk factor for the development of Alzheimer’s disease and Alzheimer’s disease‐related dementia (AD/ADRD), which is closely linked with cerebral vascular inflammation and dysfunction. We previously foun…
View article: Inhibition of Soluble Epoxide Hydrolase Ameliorates Cerebral Blood Flow Autoregulation and Cognition in Alzheimer’s Disease and Diabetes-Related Dementia Rat Models
Inhibition of Soluble Epoxide Hydrolase Ameliorates Cerebral Blood Flow Autoregulation and Cognition in Alzheimer’s Disease and Diabetes-Related Dementia Rat Models Open
Alzheimer’s Disease and Alzheimer’s Disease-related dementias (AD/ADRD) pose major global healthcare challenges, with diabetes mellitus (DM) being a key risk factor. Both AD and DM-related ADRD are characterized by reduced cerebral blood f…
View article: Genotypic and phenotypic characterisation of three local chicken ecotypes of Ghana based on principal component analysis and body measurements
Genotypic and phenotypic characterisation of three local chicken ecotypes of Ghana based on principal component analysis and body measurements Open
This study aimed to characterise three Ghanaian local chicken ecotypes, namely, Interior Savannah, Forest, and Coastal Savannah, based on morphological data and single nucleotide polymorphism (SNP) genotypes. Morphological data including b…
View article: Golden Wildebeest Days: Fragmentation and Value in South Africa’s Wildlife Economy After Apartheid
Golden Wildebeest Days: Fragmentation and Value in South Africa’s Wildlife Economy After Apartheid Open
There are renewed global efforts to make wildlife conservation the foundation for broad-based economic development. This article looks at these tendencies in the 'Kruger to Canyons' (K2C) biosphere region in South Africa, encompassing the …
View article: Improving the probability that small‐scale science will benefit conservation
Improving the probability that small‐scale science will benefit conservation Open
The foundational objective of conservation science is to maximize benefits to people and to biodiversity, but ensuring research translates into conservation action is not straightforward. We, retrospectively, evaluated nearly 20 years of s…
View article: Disparities in patient engagement with video telemedicine among high-video-use providers during the COVID-19 pandemic
Disparities in patient engagement with video telemedicine among high-video-use providers during the COVID-19 pandemic Open
Aims Known racial, ethnic, age, and socioeconomic disparities in video telemedicine engagement may widen existing health inequities. We assessed if telemedicine disparities were alleviated among patients of high-video-use providers at a la…
View article: International Tax Planning: Subsection 15(2) and Partnerships in the Foreign Affiliate Context: Interpretive Arguments in the Absence of Legislative Amendments
International Tax Planning: Subsection 15(2) and Partnerships in the Foreign Affiliate Context: Interpretive Arguments in the Absence of Legislative Amendments Open
The purpose of subsection 15(2) is to include in a shareholder's income amounts received from a corporation, either by the shareholder directly or by certain non-arm's-length persons and partnerships, in the guise of loans or other indebte…
View article: Transcriptome Analysis in Spleen Reveals Differential Regulation of Response to Newcastle Disease Virus in Two Chicken Lines
Transcriptome Analysis in Spleen Reveals Differential Regulation of Response to Newcastle Disease Virus in Two Chicken Lines Open
Enhancing genetic resistance of chickens to Newcastle Disease Virus (NDV) provides a promising way to improve poultry health, and to alleviate poverty and food insecurity in developing countries. In this study, two inbred chicken lines wit…
View article: Performance of three local chicken ecotypes of Ghana naturally exposed to velogenic Newcastle disease virus
Performance of three local chicken ecotypes of Ghana naturally exposed to velogenic Newcastle disease virus Open
This study was to evaluate the performance of three Ghanaian local ecotypes that were exposed to a natural velogenic Newcastle Disease Virus (NDV) challenge. The birds at four weeks of age had been challenged with a lentogenic (vaccine) fo…
View article: More MHC-like Class I Y mRNA Detected in Relatively Resistant Fayoumis than Susceptible Leghorns
More MHC-like Class I Y mRNA Detected in Relatively Resistant Fayoumis than Susceptible Leghorns Open
The inbred chicken lines Fayoumi and Leghorn have been shown to be relatively resistant and susceptible, respectively, to Newcastle disease virus (NDV). In this experiment we detected higher gene expression levels of MHC-like class I Y (MH…
View article: Physiological responses to heat stress in two genetically distinct chicken inbred lines
Physiological responses to heat stress in two genetically distinct chicken inbred lines Open
High ambient temperature is one of the most important environmental factors negatively impacting poultry production and health. Genetics is an important contributor in mitigating the stress response to heat. Two genetically distinct highly…
View article: Novel Mechanisms Revealed in the Trachea Transcriptome of Resistant and Susceptible Chicken Lines following Infection with Newcastle Disease Virus
Novel Mechanisms Revealed in the Trachea Transcriptome of Resistant and Susceptible Chicken Lines following Infection with Newcastle Disease Virus Open
Newcastle disease virus (NDV) has a devastating impact on poultry production in developing countries. This study examined the transcriptome of tracheal epithelial cells from two inbred chicken lines that differ in NDV susceptibility after …
View article: Additional file 3: of Resistant and susceptible chicken lines show distinctive responses to Newcastle disease virus infection in the lung transcriptome
Additional file 3: of Resistant and susceptible chicken lines show distinctive responses to Newcastle disease virus infection in the lung transcriptome Open
Contains the WGCNA output for each trait. For each transcript the module membership scores and p-values for all modules were included, and the gene significance score and p-value were given for each trait. (XLSX 81939Â kb)
View article: Does Gener Impact the Immune Response of Chicks?
Does Gener Impact the Immune Response of Chicks? Open
Sequencing technology allows us tosee how the gene expression of each genechanges under different treatment conditions. In this study, chicks of two inbred lines were challenged with Newcastle Disease Virus (NDV), a pathogen with devastati…
View article: Additional file 1: of Resistant and susceptible chicken lines show distinctive responses to Newcastle disease virus infection in the lung transcriptome
Additional file 1: of Resistant and susceptible chicken lines show distinctive responses to Newcastle disease virus infection in the lung transcriptome Open
Contains the edgeR output from all the contrasts analyzed in this study. Only transcripts with FDRâ
View article: Additional file 2: of Resistant and susceptible chicken lines show distinctive responses to Newcastle disease virus infection in the lung transcriptome
Additional file 2: of Resistant and susceptible chicken lines show distinctive responses to Newcastle disease virus infection in the lung transcriptome Open
Contains the top and bottom loading transcripts for PC1 and PC3 from pcaExplorer. (XLSX 46Â kb)
View article: Different Genetic Resistance Resulted in Distinct Response to Newcastle Disease Virus
Different Genetic Resistance Resulted in Distinct Response to Newcastle Disease Virus Open
As one of the most severe infectious diseases in the poultry industry, Newcastle disease (ND) causesa significant economic loss worldwideeven with the extensive implementation of vaccine. Tofind targets to improvegenetic resistance to NDto…
View article: RNA-seq Analysis Reveals Distinct Splenic Response of Two Chicken Lines to Newcastle Disease Virus
RNA-seq Analysis Reveals Distinct Splenic Response of Two Chicken Lines to Newcastle Disease Virus Open
Leghorn 2 dpi Leghorn 6 dpi Jibin Zhang1, Michael G. Kaiser, Melissa S. Herrmann 1, Rodrigo A. Gallardo2, David A. Bunn3, Huaijun Zhou3, Susan J Lamont1 1 Department of Animal Science, Iowa State University, Ames, IA 50010 USA 2 Population…
View article: Infection of Commercial Laying Hens with Newcastle Disease Virus: Differing Responses between Birds Provide Potential for Genetic Improvement through Selection
Infection of Commercial Laying Hens with Newcastle Disease Virus: Differing Responses between Birds Provide Potential for Genetic Improvement through Selection Open
Exotic Newcastle Disease Virus (ENDV) cause extremely rapid mortality in chickens after exposure to the virus. People rely heavily on poultry to provide protein and income in many places where NDV is not effectively controlled through vacc…