Andrea M. Burden
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View article: Investigating gender bias in pharmacy practice: a study nested in a pharmacy training exercise
Investigating gender bias in pharmacy practice: a study nested in a pharmacy training exercise Open
Background Evidence on gender bias in the healthcare system is growing, and pharmacists have an important role in Swiss primary care. Yet, research on gender bias among pharmacists remains extremely sparse and highly relevant. Methods This…
View article: Age disparities in adverse reactions of drugs used in pain therapies in Switzerland
Age disparities in adverse reactions of drugs used in pain therapies in Switzerland Open
Pain therapies are prescribed to a significant proportion of the population but also associated with adverse drug reactions (ADRs). The prescription of pain therapies requires careful consideration of their safety profiles in the context o…
View article: Optimizing deprescribing of hospital-initiated opioids: a multi-level consensus study bridging evidence, expertise, and patient perspectives
Optimizing deprescribing of hospital-initiated opioids: a multi-level consensus study bridging evidence, expertise, and patient perspectives Open
Hospital-initiated opioid analgesics that extend beyond discharge can lead to long-term use and adverse outcomes. Despite a growing understanding of opioid-related harms, there is a lack of published protocols for structured deprescribing …
View article: The relationship between osteoporosis treatment history and receipt of a second zoledronic acid dose
The relationship between osteoporosis treatment history and receipt of a second zoledronic acid dose Open
View article: The rise and fall of raloxifene use for osteoporosis, 1999–2022
The rise and fall of raloxifene use for osteoporosis, 1999–2022 Open
View article: Optimizing hospital opioid deprescribing: a multi-level consensus study bridging evidence, expertise, and patient perspectives
Optimizing hospital opioid deprescribing: a multi-level consensus study bridging evidence, expertise, and patient perspectives Open
Hospital-initiated opioid analgesics that extend beyond discharge can lead to long-term use and adverse outcomes. Despite a growing understanding of opioid-related harms, there is a lack of published protocols for structured deprescribing …
View article: Integrating Sustainability Pillars Into Trial Design Decision‐Making: Results of an International Survey
Integrating Sustainability Pillars Into Trial Design Decision‐Making: Results of an International Survey Open
The pharmaceutical industry is increasingly shifting to decentralized clinical trials (DCTs) conducted at the patient's home, sometimes including trial material home delivery. The traditional clinical trial (CT) is conducted at the investi…
View article: Direct Healthcare Cost of Fractures in Patients With Type 1 Diabetes: A Population-Based Cohort Study in Denmark
Direct Healthcare Cost of Fractures in Patients With Type 1 Diabetes: A Population-Based Cohort Study in Denmark Open
Context Patients with type 1 diabetes (T1D) have increased risk of post-fracture complications, such as impaired healing and surgical complications compared to patients without diabetes. However, it is not known if this translates to highe…
View article: How Consistent are Anti-Infective Drug Dosing Recommendations Across Three European Paediatric Formularies?
How Consistent are Anti-Infective Drug Dosing Recommendations Across Three European Paediatric Formularies? Open
View article: Fracture-Related Safety Reporting of JAK Inhibitors: An Analysis from the WHO Global VigiBase
Fracture-Related Safety Reporting of JAK Inhibitors: An Analysis from the WHO Global VigiBase Open
View article: Increased Risk of Fracture Among Patients With Iron Overload: A Population-based Matched Cohort Study
Increased Risk of Fracture Among Patients With Iron Overload: A Population-based Matched Cohort Study Open
Introduction Iron overloading disorders are associated with decreased bone mineral density. However, evidence on fracture risk is scarce. Therefore, we evaluated the risk of fracture associated with iron overload disorders compared to matc…
View article: Inpatient opioid prescribing patterns and their effect on rehospitalisations: a nested case-control study using data from a Swiss public acute hospital
Inpatient opioid prescribing patterns and their effect on rehospitalisations: a nested case-control study using data from a Swiss public acute hospital Open
AIMS OF THE STUDY: Opioid prescriptions have increased in Switzerland, even though current guidelines warn of their harms. If opioids for postoperative analgesia are not tapered before hospital discharge, patients are at risk of adverse ev…
View article: Impact of blue-collar vs. white-collar occupations on disease burden in psoriatic arthritis patients: A Swiss clinical quality management in rheumatic diseases cohort study
Impact of blue-collar vs. white-collar occupations on disease burden in psoriatic arthritis patients: A Swiss clinical quality management in rheumatic diseases cohort study Open
Biomechanical stress may exacerbate inflammation in psoriatic arthritis (PsA). This study aimed to investigate disease activity, work disability, and drug response/retention rates in PsA patients among two different occupation’s types: blu…
View article: Opioid exit plans for tapering postoperative pain control in noncancer patients: a systematic review
Opioid exit plans for tapering postoperative pain control in noncancer patients: a systematic review Open
View article: The association of bariatric surgery and carpal tunnel syndrome: A propensity score-matched cohort study
The association of bariatric surgery and carpal tunnel syndrome: A propensity score-matched cohort study Open
Our results suggest that marked weight does not have a lasting impact on the reduction of CTS incidence.
View article: Site-specific fracture incidence rates among patients with type 1 diabetes, type 2 diabetes or without diabetes in Denmark (1997-2017)
Site-specific fracture incidence rates among patients with type 1 diabetes, type 2 diabetes or without diabetes in Denmark (1997-2017) Open
Objective: To investigate trends of incidence rates at different fracture sites for patients with type 1 diabetes and type 2 diabetes compared to patients without diabetes in Denmark in 1997-2017. Research Design…
View article: Prevalence of potentially inappropriate medications among newly treated patients with type 2 diabetes in UK primary care
Prevalence of potentially inappropriate medications among newly treated patients with type 2 diabetes in UK primary care Open
Aims The aim of this study was to estimate the prevalence of potentially inappropriate prescriptions (PIPs) in patients starting their first noninsulin antidiabetic treatment (NIAD) using two explicit process measures of the appropriatenes…
View article: Comparative effectiveness of biologics in patients with rheumatoid arthritis stratified by body mass index: a cohort study in a Swiss registry
Comparative effectiveness of biologics in patients with rheumatoid arthritis stratified by body mass index: a cohort study in a Swiss registry Open
Objectives Obesity is associated with lower treatment response in patients with rheumatoid arthritis (RA). In patients with obesity, abatacept was suggested as a preferable option to tumour necrosis factor-alpha inhibitors. We aimed to ass…
View article: Real-World Effectiveness of Semaglutide and Liraglutide for Weight Management in Overweight or Obese Adults with or Without Type-2 Diabetes Mellitus: Emulation of Randomised Clinical Trials Using UK Electronic Medical Records
Real-World Effectiveness of Semaglutide and Liraglutide for Weight Management in Overweight or Obese Adults with or Without Type-2 Diabetes Mellitus: Emulation of Randomised Clinical Trials Using UK Electronic Medical Records Open
View article: Antiplatelet Therapy Guided by <i>CYP2C19</i> Point-of-Care Pharmacogenetics Plus Multidimensional Treatment Decisions
Antiplatelet Therapy Guided by <i>CYP2C19</i> Point-of-Care Pharmacogenetics Plus Multidimensional Treatment Decisions Open
Aim: Implementation of CYP2C19 point-of-care (POC) pharmacogenetic (PGx) testing with personalized treatment recommendations. Methods: POC CYP2C19 genotyping plus expert evaluation of risk factors for ischemic a…
View article: Baricitinib and tofacitinib off‐target profile, with a focus on Alzheimer's disease
Baricitinib and tofacitinib off‐target profile, with a focus on Alzheimer's disease Open
INTRODUCTION Janus kinase (JAK) inhibitors were recently identified as promising drug candidates for repurposing in Alzheimer's disease (AD) due to their capacity to suppress inflammation via modulation of JAK/STAT signaling pathways. Besi…
View article: Methodological guidance for the use of real-world data to measure exposure and utilization patterns of osteoporosis medications
Methodological guidance for the use of real-world data to measure exposure and utilization patterns of osteoporosis medications Open
View article: Sex‐ and Age Group‐Specific Fracture Incidence Rates Trends for Type 1 and 2 Diabetes Mellitus
Sex‐ and Age Group‐Specific Fracture Incidence Rates Trends for Type 1 and 2 Diabetes Mellitus Open
The incidence of major osteoporotic fractures has declined in men and women in Western countries over the last two decades. Although fracture risk is higher in persons with diabetes mellitus, trends of fractures remain unknown in men and w…
View article: Longitudinal associations between body mass index and changes in disease activity and radiographic progression in rheumatoid arthritis patients treated with infliximab
Longitudinal associations between body mass index and changes in disease activity and radiographic progression in rheumatoid arthritis patients treated with infliximab Open
Objectives Treatment response is worse in obese patients with rheumatoid arthritis (RA), including patients on weight-adjusted therapies like infliximab. We aimed to assess the association between body mass index (BMI) and changes in RA di…
View article: Baricitinib and tofacitinib off-target profile, with a focus on Alzheimer’s disease
Baricitinib and tofacitinib off-target profile, with a focus on Alzheimer’s disease Open
Introduction: Janus Kinase (JAK) inhibitors were recently identified as promising drug candidates for repurposing in Alzheimer’s disease (AD) due to their capacity to suppress inflammation via modulation of JAK/STAT signalling pathways. Be…
View article: JAK-inhibitors and risk on serious viral infection, venous thromboembolism and cardiac events in patients with rheumatoid arthritis: A protocol for a prevalent new-user cohort study using the Danish nationwide DANBIO register
JAK-inhibitors and risk on serious viral infection, venous thromboembolism and cardiac events in patients with rheumatoid arthritis: A protocol for a prevalent new-user cohort study using the Danish nationwide DANBIO register Open
Janus Kinase inhibitors (JAKis) are targeted synthetic disease-modifying antirheumatic drugs and represent an important alternative to treat patients with moderate to high rheumatoid arthritis (RA) disease activity. Safety concerns associa…
View article: Identification of Medication Prescription Errors and Factors of Clinical Relevance in 314 Hospitalized Patients for Improved Multidimensional Clinical Decision Support Algorithms
Identification of Medication Prescription Errors and Factors of Clinical Relevance in 314 Hospitalized Patients for Improved Multidimensional Clinical Decision Support Algorithms Open
Potential medication errors and related adverse drug events (ADE) pose major challenges in clinical medicine. Clinical decision support systems (CDSSs) help identify preventable prescription errors leading to ADEs but are typically charact…
View article: Design and Execution of Sustainable Decentralized Clinical Trials
Design and Execution of Sustainable Decentralized Clinical Trials Open
The decentralized clinical trial (DCT) approach is increasingly recognized as a means to accelerate the development of potential therapeutic interventions. DCTs have a crucial advantage over traditional clinical trials: patients are monito…
View article: Patient groups in Rheumatoid arthritis identified by deep learning respond differently to biologic or targeted synthetic DMARDs
Patient groups in Rheumatoid arthritis identified by deep learning respond differently to biologic or targeted synthetic DMARDs Open
Cycling of biologic or targeted synthetic disease modifying antirheumatic drugs (b/tsDMARDs) in rheumatoid arthritis (RA) patients due to non-response is a problem preventing and delaying disease control. We aimed to assess and validate tr…
View article: POS0825 CANCER RISK IN PATIENTS WITH RHEUMATOID ARTHRITIS TREATED WITH JANUS KINASE INHIBITORS: A NATIONWIDE DANISH REGISTER-BASED COHORT STUDY
POS0825 CANCER RISK IN PATIENTS WITH RHEUMATOID ARTHRITIS TREATED WITH JANUS KINASE INHIBITORS: A NATIONWIDE DANISH REGISTER-BASED COHORT STUDY Open