David C. Chain
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View article: Mass spectrometry quantifies target engagement for a KRASG12C inhibitor in FFPE tumor tissue
Mass spectrometry quantifies target engagement for a KRASG12C inhibitor in FFPE tumor tissue Open
Background Quantification of drug-target binding is critical for confirming that drugs reach their intended protein targets, understanding the mechanism of action, and interpreting dose-response relationships. For covalent inhibitors, targ…