David C. Consoli
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View article: Acute manganese exposure impairs glutamatergic function in a young mouse model of Alzheimer’s disease
Acute manganese exposure impairs glutamatergic function in a young mouse model of Alzheimer’s disease Open
View article: Altered EEG, disrupted hippocampal long-term potentiation and neurobehavioral deficits implicate a delirium-like state in a mouse model of sepsis
Altered EEG, disrupted hippocampal long-term potentiation and neurobehavioral deficits implicate a delirium-like state in a mouse model of sepsis Open
Sepsis and systemic inflammation are often accompanied by severe encephalopathy, sleep disruption and delirium that strongly correlate with poor clinical outcomes including long-term cognitive deficits. The cardinal manifestations of delir…
View article: Manganese-induced hyperactivity and dopaminergic dysfunction depend on age, sex and YAC128 genotype
Manganese-induced hyperactivity and dopaminergic dysfunction depend on age, sex and YAC128 genotype Open
View article: Altered synaptic glutamate homeostasis contributes to cognitive decline in young APP/PSEN1 mice
Altered synaptic glutamate homeostasis contributes to cognitive decline in young APP/PSEN1 mice Open
View article: Ascorbate deficiency decreases dopamine release in gulo<sup>–/–</sup> and APP/PSEN1 mice
Ascorbate deficiency decreases dopamine release in gulo<sup>–/–</sup> and APP/PSEN1 mice Open
Dopamine (DA) has important roles in learning, memory, and motivational processes and is highly susceptible to oxidation. In addition to dementia, Alzheimer's disease (AD) patients frequently exhibit decreased motivation, anhedonia, and sl…
View article: A Cecal Slurry Mouse Model of Sepsis Leads to Acute Consumption of Vitamin C in the Brain
A Cecal Slurry Mouse Model of Sepsis Leads to Acute Consumption of Vitamin C in the Brain Open
Vitamin C (ascorbate, ASC) is a critical antioxidant in the body with specific roles in the brain. Despite a recent interest in vitamin C therapies for critical care medicine, little is known about vitamin C regulation during acute inflamm…
View article: P3‐180: ALTERED SYNAPTIC GLUTAMATE HOMEOSTASIS UNDERLIES SEIZURE‐INDUCED COGNITIVE DECLINE IN YOUNG APP/PSEN1 MICE
P3‐180: ALTERED SYNAPTIC GLUTAMATE HOMEOSTASIS UNDERLIES SEIZURE‐INDUCED COGNITIVE DECLINE IN YOUNG APP/PSEN1 MICE Open
Recent evidence has highlighted the co-occurrence of epilepsy with Alzheimer's disease as a significant contributor to cognitive decline. Minor epileptogenic events, such as absence seizures, and events occurring during sleep may go uniden…