Explanipedia

Endovascular management of dural arteriovenous fistulae of the anterior condylar confluence Open

David C. Lauzier, Arindam Chatterjee, Joshua W. Osbun · 2025

Introduction: Dural arteriovenous fistulae (dAVFs) can lead to subarachnoid hemorrhage and other devastating complications. A rare subtype of dAVFs is those located in the anterior condylar confluence adjacent to the hypoglossal canal. The…

Microglia and macrophages in brain injury and repair after subarachnoid hemorrhage Open

David C. Lauzier, Harry V. Vinters, Shino Magaki · 2024

Role of microglia after subarachnoid hemorrhage Open

David C. Lauzier, Umeshkumar Athiraman · 2024

Subarachnoid hemorrhage is a devastating sequela of aneurysm rupture. Because it disproportionately affects younger patients, the population impact of hemorrhagic stroke from subarachnoid hemorrhage is substantial. Secondary brain injury i…

Conditioning-based therapeutics for aneurysmal subarachnoid hemorrhage – A critical review Open

Sangami Pugazenthi, Aaron J. Norris, David C. Lauzier, Abhijit V. Lele, Anna L. Huguenard , et al. · 2023

Aneurysmal subarachnoid hemorrhage (SAH) carries significant mortality and morbidity, with nearly half of SAH survivors having major cognitive dysfunction that impairs their functional status, emotional health, and quality of life. Apart f…

Peripheral macrophages in the development and progression of structural cerebrovascular pathologies Open

David C. Lauzier, Anja I. Srienc, Ananth K. Vellimana, Ralph G. Dacey, Gregory J. Zipfel · 2023

The human cerebrovascular system is responsible for maintaining neural function through oxygenation, nutrient supply, filtration of toxins, and additional specialized tasks. While the cerebrovascular system has resilience imparted by elabo…

Complications and risk factors after digital subtraction angiography: 1-year single-center study Open

David C. Lauzier, Alexander P. Conway · 2023

29. Impact of Age at Endoscopic Metopic Synostosis Repair on Anthropometric Outcomes Open

Sarah N. Chiang, Erin C. Peterson, David C. Lauzier, Sean D. McEvoy, Gary B. Skolnick , et al. · 2023

OBJECTIVE: Endoscopic strip craniectomy for metopic craniosynostosis relies on rapid growth and post-operative helmeting for correction. Endoscopic repair is generally performed before patients reach 4 months of age, and outcomes in older …

A review of technological innovations leading to modern endovascular brain aneurysm treatment Open

David C. Lauzier, Anna L. Huguenard, Anja I. Srienc, Samuel J. Cler, Joshua W. Osbun , et al. · 2023

Tools and techniques utilized in endovascular brain aneurysm treatment have undergone rapid evolution in recent decades. These technique and device-level innovations have allowed for treatment of highly complex intracranial aneurysms and i…

Early Brain Injury After Subarachnoid Hemorrhage: Incidence and Mechanisms Open

David C. Lauzier, Keshav Jayaraman, Jane Yuan, Deepti Diwan, Ananth K. Vellimana , et al. · 2023

Aneurysmal subarachnoid hemorrhage is a devastating condition causing significant morbidity and mortality. While outcomes from subarachnoid hemorrhage have improved in recent years, there continues to be significant interest in identifying…

Neurointerventional management of cerebrovascular trauma Open

David C. Lauzier, Arindam Chatterjee, Akash P. Kansagra · 2022

Traumatic cerebrovascular injuries following blunt or penetrating trauma are common and carry a high risk of permanent disability or death. Proper screening, diagnosis, and treatment of these lesions is essential to improve patient outcome…

Comparison of transarterial n-BCA and Onyx embolization of brain arteriovenous malformations: A single-center 18-year retrospective analysis Open

David C. Lauzier · 2022

Impact of age at endoscopic metopic synostosis repair on anthropometric outcomes Open

Sarah N. Chiang, Erin C. Peterson, David C. Lauzier, Sean D. McEvoy, Gary B. Skolnick , et al. · 2022

OBJECTIVE Endoscopic strip craniectomy for metopic craniosynostosis relies on rapid growth and postoperative helmeting for correction. Endoscopic repair is generally performed before patients reach 4 months of age, and outcomes in older pa…

E-143 Predicting the need for y-stenting in complex wide-neck bifurcation aneurysms Open

David C. Lauzier, Barry Root, J Osbun, A Chatterjee, C Moran , et al. · 2022

Introduction Stent-assisted coiling of wide neck bifurcation aneurysms in the anterior communicating artery and basilar tip region is performed utilizing various single and multi-stent configurations. One common configuration is the Y-sten…

E-036 Imaging and Epidemiology of Moyamoya Vasculopathy Open

David C. Lauzier, K Guilliams, A Kansagra · 2022

Introduction Moyamoya vasculopathy comprises both moyamoya disease and moyamoya syndrome, and is characterised by progressive occlusion of the distal ICA, proximal ACA, and proximal MCA. If left unaddressed, moyamoya vasculopathy may lead …

E-084 Day-of-week effect on safety of elective brain aneurysm treatment Open

David C. Lauzier, Samuel J. Cler, Keshav Jayaraman, Ankita Chatterjee, Joshua W. Osbun , et al. · 2022

Introduction Elective treatment of intracranial aneurysms comprises a large share of neurointerventional practice. With increasing demand for endovascular aneurysm treatment, there is a need to assess factors such as operator fatigue and t…

E-158 Trends in elective treatment strategies for brain aneurysms Open

David C. Lauzier, S Cler, K Jayaraman, J Osbun, A Chatterjee , et al. · 2022

Introduction Elective treatment of intracranial aneurysms comprises a large share of neurointerventional practice, with a proliferation of new devices contributing to the tremendous growth of this area. Traditionally, endovascular treatmen…

E-185 Medical management of in-stent stenosis following pipeline embolization of brain aneurysms Open

David C. Lauzier, S Cler, J Osbun, A Chatterjee, C Moran , et al. · 2022

Introduction Flow diversion of intracranial aneurysms with the Pipeline embolization device (PED) may produce angiographically apparent stenosis within the PED, which can lead to secondary ischemic complications. In-stent stenosis can be t…

E-199 Acute imaging following elective brain aneurysm treatment Open

David C. Lauzier, S Cler, K Jayaraman, A Chatterjee, J Osbun , et al. · 2022

Introduction Elective treatment of intracranial aneurysms comprises a significant share of neurointerventional practice. Following treatment, patients are typically monitored in the hospital due to the risk of acute complications, but the …

E-250 Flow diversion of superior cerebellar artery aneurysms Open

David C. Lauzier, S Cler, J Osbun, A Chatterjee, C Moran , et al. · 2022

Introduction Flow diversion is commonly used to treat intracranial aneurysms in various regions of the cerebral vasculature, but is only approved for use in the internal carotid arteries. Treatment of superior cerebellar artery (SCA) aneur…

Retreatment of previously flow diverted intracranial aneurysms with the pipeline embolization device Open

David C. Lauzier, Samuel J. Cler, Arindam Chatterjee, Joshua W. Osbun, Christopher J. Moran , et al. · 2022

Background and Purpose Flow diversion of intracranial aneurysms with the Pipeline Embolization Device (PED) is frequently performed, but the outcomes of retreatment for aneurysms that failed to occlude after prior treatment with PED have n…

Comparative study of on-label versus off-label treatment of intracranial aneurysms with the Pipeline embolization device Open

Samuel J. Cler, David C. Lauzier, Arindam Chatterjee, Joshua W. Osbun, Christopher J. Moran , et al. · 2022

OBJECTIVE The Pipeline embolization device (PED) is widely used for the treatment of intracranial aneurysms, including in off-label applications. In this work, the authors compared the real-world efficacy and safety of PED use in on-label …

Neurointerventional management of cerebrovascular trauma Open

David C. Lauzier, Arindam Chatterjee, Akash P. Kansagra · 2021

Traumatic cerebrovascular injuries following blunt or penetrating trauma are common and carry a high risk of permanent disability or death. Proper screening, diagnosis, and treatment of these lesions is essential to improve patient outcome…

E-145 Safety of pediatric cerebral angiography Open

David C. Lauzier, Joshua W. Osbun, Arindam Chatterjee, Christopher J. Moran, Akash P. Kansagra · 2021

Introduction/Purpose Catheter-based cerebral angiography is commonly used for neurovascular diagnosis in children. In this work, we aim to quantify the complication rate of cerebral angiography in children, characterize these complications…

E-077 Pipeline embolization of MCA aneurysms in the M2-M4 Segment: Multicenter cohort and meta-analysis Open

David C. Lauzier, Brandon Root, Yasha Kayan, Josser E Delgado Almandoz, Joshua W. Osbun , et al. · 2021

Introduction/Purpose Flow diversion of distal MCA aneurysms in the M2-M4 segments with PED is promising, but further study is needed. Here, we seek to quantify the safety and efficacy of Pipeline embolization in the M2-M4 region in a multi…

E-146 The value of long-term angiographic follow-up following pipeline embolization of intracranial aneurysms Open

David C. Lauzier, Samuel J. Cler, Akash P. Kansagra · 2021

Introduction/Purpose Flow diversion of intracranial aneurysms with the Pipeline embolization device is commonly performed, but the value of long-term angiographic follow-up has not been rigorously evaluated. Here, we examine the prevalence…

O-005 Comparison of on-label versus off-label treatment of intracranial aneurysms with the pipeline embolization devices Open

Samuel J. Cler, David C. Lauzier, Akash P. Kansagra · 2021

Background and Purpose The Pipeline Embolization Device (PED) is widely used for treatment of intracranial aneurysms, including in off-label applications. The performance of PED in off-label applications is not well understood. In this wor…

E-106 Timeline of occlusion for intracranial aneurysms treated with pipeline embolization devices Open

Samuel J. Cler, David C. Lauzier, Akash P. Kansagra · 2021

Introduction/Purpose The Pipeline Embolization Device (PED) is commonly used to treat intracranial aneurysms. The rate of aneurysm occlusion at pre-specified timepoints after PED treatment is known from clinical trials, but the actual time…

E-078 Pipeline embolization of proximal middle cerebral artery aneurysms: A multicenter cohort study Open

David C. Lauzier, Brandon Root, Yasha Kayan, Josser E Delgado Almandoz, Joshua W. Osbun , et al. · 2021

Introduction/Purpose Flow diversion of aneurysms located in the M1 segment and middle cerebral artery bifurcation with Pipeline embolization device is sometimes performed, but further study is needed to support its regular use in aneurysm …

Pipeline embolization of proximal middle cerebral artery aneurysms: A multicenter cohort study Open

David C. Lauzier, Brandon Root, Yasha Kayan, Josser E Delgado Almandoz, Joshua W. Osbun , et al. · 2021

Background and purpose Flow diversion of aneurysms located in the M1 segment and middle cerebral artery bifurcation with Pipeline embolization device is sometimes performed, but further study is needed to support its regular use in aneurys…

Pipeline embolization of distal posterior inferior cerebellar artery aneurysms Open

David C. Lauzier, Brandon Root, Yasha Kayan, Josser E Delgado Almandoz, Joshua W. Osbun , et al. · 2021

Background and purpose Flow diversion is commonly used to treat intracranial aneurysms in various regions of the cerebral vasculature, but is only approved for use in the internal carotid arteries. Treatment of distal PICA aneurysms with P…

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