David C. Tack
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View article: Surveillance of single nucleotide polymorphisms correlated to macrocyclic lactone resistance in Dirofilaria immitis from client-owned dogs across the United States
Surveillance of single nucleotide polymorphisms correlated to macrocyclic lactone resistance in Dirofilaria immitis from client-owned dogs across the United States Open
Dirofilaria immitis is a parasitic filarial nematode and the causative agent of heartworm disease in canids and other species. Heartworm disease is predominantly managed via macrocyclic lactone (ML) - based chemoprophylactics. Through oppo…
View article: Transcriptome-wide probing reveals RNA thermometers that regulate translation of glycerol permease genes in<i>Bacillus subtilis</i>
Transcriptome-wide probing reveals RNA thermometers that regulate translation of glycerol permease genes in<i>Bacillus subtilis</i> Open
RNA structure regulates bacterial gene expression by several distinct mechanisms via environmental and cellular stimuli, one of which is temperature. While some genome-wide studies have focused on heat shock treatments and the subsequent t…
View article: eIF4A1-dependent mRNAs employ purine-rich 5’UTR sequences to activate localised eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation
eIF4A1-dependent mRNAs employ purine-rich 5’UTR sequences to activate localised eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation Open
Altered eIF4A1 activity promotes translation of highly structured, eIF4A1-dependent oncogene mRNAs at root of oncogenic translational programmes. It remains unclear how these mRNAs recruit and activate eIF4A1 unwinding specifically to faci…
View article: Purine-rich RNA sequences in the 5’UTR site-specifically regulate eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation
Purine-rich RNA sequences in the 5’UTR site-specifically regulate eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation Open
Oncogenic translational programmes underpin cancer development and are often driven by dysregulation of oncogenic signalling pathways that converge on the eukaryotic translation initiation (eIF) 4F complex. Altered eIF4F activity promotes …
View article: Structure-seq2 probing of RNA structure upon amino acid starvation reveals both known and novel RNA switches in <i>Bacillus subtilis</i>
Structure-seq2 probing of RNA structure upon amino acid starvation reveals both known and novel RNA switches in <i>Bacillus subtilis</i> Open
RNA structure influences numerous processes in all organisms. In bacteria, these processes include transcription termination and attenuation, small RNA and protein binding, translation initiation, and mRNA stability, and can be regulated v…
View article: Structure-seq2 probing of RNA structure upon amino acid starvation reveals both known and novel RNA switches in<i>Bacillus subtilis</i>
Structure-seq2 probing of RNA structure upon amino acid starvation reveals both known and novel RNA switches in<i>Bacillus subtilis</i> Open
RNA structure influences numerous processes in all organisms. In bacteria, these processes include transcription termination and attenuation, small RNA and protein binding, translation initiation, and mRNA stability, and can be regulated v…
View article: Tissue-specific changes in the RNA structurome mediate salinity response in <i>Arabidopsis</i>
Tissue-specific changes in the RNA structurome mediate salinity response in <i>Arabidopsis</i> Open
Little is known concerning the effects of abiotic factors on in vivo RNA structures. We applied Structure-seq to assess the in vivo mRNA structuromes of Arabidopsis thaliana under salinity stress, which negatively impacts agriculture. Stru…
View article: mRNA structural elements immediately upstream of the start codon dictate dependence upon eIF4A helicase activity.
mRNA structural elements immediately upstream of the start codon dictate dependence upon eIF4A helicase activity. Open
BACKGROUND:The RNA helicase eIF4A1 is a key component of the translation initiation machinery and is required for the translation of many pro-oncogenic mRNAs. There is increasing interest in targeting eIF4A1 therapeutically in cancer, thus…
View article: mRNA structural elements immediately upstream of the start codon dictate dependence upon eIF4A helicase activity
mRNA structural elements immediately upstream of the start codon dictate dependence upon eIF4A helicase activity Open
View article: Tissue-specific changes in the RNA structurome mediate salinity response in<i>Arabidopsis</i>
Tissue-specific changes in the RNA structurome mediate salinity response in<i>Arabidopsis</i> Open
RNA structures are influenced by their physico-chemical environment. Few studies have assessed genome-wide impacts of abiotic stresses on in vivo RNA structure, however, and none have investigated tissue-specificity. We applied our Structu…
View article: Genome-wide RNA structurome reprogramming by acute heat shock globally regulates mRNA abundance
Genome-wide RNA structurome reprogramming by acute heat shock globally regulates mRNA abundance Open
The heat shock response is crucial for organism survival in natural environments. RNA structure is known to influence numerous processes related to gene expression, but there have been few studies on the global RNA structurome as it prevai…
View article: Weed evolution: Genetic differentiation among wild, weedy, and crop radish
Weed evolution: Genetic differentiation among wild, weedy, and crop radish Open
Approximately 200 weed species are responsible for more than 90% of crop losses and these comprise less than one percent of all named plant species, suggesting that there are only a few evolutionary routes that lead to weediness. Agricultu…
View article: How well do you know your mutation? Complex effects of genetic background on expressivity, complementation, and ordering of allelic effects
How well do you know your mutation? Complex effects of genetic background on expressivity, complementation, and ordering of allelic effects Open
For a given gene, different mutations influence organismal phenotypes to varying degrees. However, the expressivity of these variants not only depends on the DNA lesion associated with the mutation, but also on factors including the geneti…
View article: Structure-seq2: sensitive and accurate genome-wide profiling of RNA structure in vivo
Structure-seq2: sensitive and accurate genome-wide profiling of RNA structure in vivo Open
RNA serves many functions in biology such as splicing, temperature sensing, and innate immunity. These functions are often determined by the structure of RNA. There is thus a pressing need to understand RNA structure and how it changes dur…
View article: How well do you know your mutation? Complex effects of genetic background on expressivity, complementation, and ordering of allelic effects
How well do you know your mutation? Complex effects of genetic background on expressivity, complementation, and ordering of allelic effects Open
For a given gene, different mutations influence organismal phenotypes to varying degrees. However, the expressivity of these variants not only depends on the DNA lesion associated with the mutation, but also on factors including the geneti…
View article: The evolution of alternative splicing after polyploidy
The evolution of alternative splicing after polyploidy Open
Gene and genome duplications have made major contributions to the genomes of eukaryotes. Alternative splicing modulates gene expression and alters protein function. First, I examine alternative splicing patterns in the allopolyploid Brassi…
View article: ChandlerChariPLoSGenetics2017
ChandlerChariPLoSGenetics2017 Open
This is the data set and associated scripts for the forthcoming paper in PLoS Genetics (2017).Chandler, C.H., Chari, S., et al.How well do you know your mutation? Complex effects of genetic background on expressivity, complementation, and …